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ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains [ Homo sapiens (human) ]

Gene ID: 64771, updated on 21-Dec-2019

Summary

Official Symbol
ILRUNprovided by HGNC
Official Full Name
inflammation and lipid regulator with UBA-like and NBR1-like domainsprovided by HGNC
Primary source
HGNC:HGNC:21215
See related
Ensembl:ENSG00000196821 MIM:612217
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FP852; C6orf106; dJ391O22.4
Expression
Ubiquitous expression in fat (RPKM 19.9), testis (RPKM 15.9) and 25 other tissues See more
Orthologs

Genomic context

See ILRUN in Genome Data Viewer
Location:
6p21.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (34587288..34696767, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (34555065..34664625, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene SAM pointed domain containing ETS transcription factor Neighboring gene IFITM3 pseudogene 3 Neighboring gene ribosomal protein L7 pseudogene 25 Neighboring gene NFE2L2 motif-containing MPRA enhancer 28 Neighboring gene uncharacterized LOC105375028 Neighboring gene RNA, 7SL, cytoplasmic 200, pseudogene Neighboring gene uncharacterized LOC101929243 Neighboring gene V-type proton ATPase subunit F pseudogene Neighboring gene ribosomal protein S10 pseudogene 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Genome-wide association analysis identifies 20 loci that influence adult height.
NHGRI GWA Catalog
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog
Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4614, FLJ22195, FLJ32402

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
innate immune response IEA
Inferred from Electronic Annotation
more info
 
macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of type I interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein ILRUN
Names
inflammation and lipid regulator with UBA-like and NBR1-like domains protein
uncharacterized protein C6orf106

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022758.6NP_073595.2  protein ILRUN isoform b

    See identical proteins and their annotated locations for NP_073595.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    AL031577, AL451165
    Consensus CDS
    CCDS4795.1
    UniProtKB/Swiss-Prot
    Q9H6K1
    Related
    ENSP00000363138.3, ENST00000374026.7
    Conserved Domains (2) summary
    cd14349
    Location:2364
    UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
    cd14947
    Location:71169
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  2. NM_024294.4NP_077270.1  protein ILRUN isoform a

    See identical proteins and their annotated locations for NP_077270.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL031577, AL451165
    Consensus CDS
    CCDS4796.1
    UniProtKB/Swiss-Prot
    Q9H6K1
    UniProtKB/TrEMBL
    A0A024RCW2
    Related
    ENSP00000363135.3, ENST00000374023.8
    Conserved Domains (2) summary
    cd14349
    Location:2364
    UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
    cd14947
    Location:71180
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    34587288..34696767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249298.3XP_005249355.1  protein ILRUN isoform X1

    See identical proteins and their annotated locations for XP_005249355.1

    Conserved Domains (2) summary
    cd14349
    Location:2364
    UBA_CF106; UBA-like domain found in uncharacterized protein C6orf106 and similar proteins
    cd14947
    Location:71180
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

RNA

  1. XR_926300.3 RNA Sequence

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