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S100PBP S100P binding protein [ Homo sapiens (human) ]

Gene ID: 64766, updated on 17-Sep-2022

Summary

Official Symbol
S100PBPprovided by HGNC
Official Full Name
S100P binding proteinprovided by HGNC
Primary source
HGNC:HGNC:25768
See related
Ensembl:ENSG00000116497 MIM:611889; AllianceGenome:HGNC:25768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S100PBPR
Summary
This gene encodes a protein that was originally identified by its interaction with S100 calcium-binding protein P. Expression of this protein has been reported to be associated with pancreatic ductal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
Expression
Broad expression in testis (RPKM 19.6), lymph node (RPKM 6.5) and 24 other tissues See more
Orthologs
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Genomic context

See S100PBP in Genome Data Viewer
Location:
1p35.1
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (32816562..32858879)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32677224..32718671)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (33283043..33324480)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8469 Neighboring gene KIAA1522 Neighboring gene Sharpr-MPRA regulatory region 15696 Neighboring gene tyrosyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC105378631 Neighboring gene fibronectin type III domain containing 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12903, DKFZp313K2325

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
S100P-binding protein
Names
S100P binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031988.1 RefSeqGene

    Range
    5212..46434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256121.2NP_001243050.1  S100P-binding protein

    See identical proteins and their annotated locations for NP_001243050.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same protein.
    Source sequence(s)
    AK022965, AK090711, BX647916
    Consensus CDS
    CCDS30666.1
    UniProtKB/Swiss-Prot
    Q96BU1, Q9H997
    UniProtKB/TrEMBL
    A0A0S2Z5M0
    Related
    ENSP00000362575.1, ENST00000373476.5
    Conserved Domains (1) summary
    pfam15427
    Location:22402
    S100PBPR; S100P-binding protein
  2. NM_022753.4NP_073590.2  S100P-binding protein

    See identical proteins and their annotated locations for NP_073590.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 3 both encode the same protein.
    Source sequence(s)
    AK022965, BX647916
    Consensus CDS
    CCDS30666.1
    UniProtKB/Swiss-Prot
    Q96BU1, Q9H997
    UniProtKB/TrEMBL
    A0A0S2Z5M0
    Related
    ENSP00000362574.5, ENST00000373475.10
    Conserved Domains (1) summary
    pfam15427
    Location:22402
    S100PBPR; S100P-binding protein

RNA

  1. NR_135106.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction and contains two alternate exons compared to variant 1. The exon combination at the 5' UTR has not been determined. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA557330, AC114493, AK090711, BX647916, KU178751
  2. NR_135107.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon compared to variant 1. The exon combination at the 5' UTR has not been determined. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA557330, AC114493, AK022965, AK090711, BX647916

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    32816562..32858879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541962.3XP_011540264.1  S100P-binding protein isoform X1

    See identical proteins and their annotated locations for XP_011540264.1

    UniProtKB/Swiss-Prot
    Q96BU1, Q9H997
    UniProtKB/TrEMBL
    A0A0S2Z5M0
    Conserved Domains (1) summary
    pfam15427
    Location:22402
    S100PBPR; S100P-binding protein
  2. XM_047428036.1XP_047283992.1  S100P-binding protein isoform X2

  3. XM_047428029.1XP_047283985.1  S100P-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q9H997
    UniProtKB/TrEMBL
    A0A0S2Z5M0
  4. XM_011541961.3XP_011540263.1  S100P-binding protein isoform X1

    See identical proteins and their annotated locations for XP_011540263.1

    UniProtKB/Swiss-Prot
    Q96BU1, Q9H997
    UniProtKB/TrEMBL
    A0A0S2Z5M0
    Conserved Domains (1) summary
    pfam15427
    Location:22402
    S100PBPR; S100P-binding protein
  5. XM_047428035.1XP_047283991.1  S100P-binding protein isoform X2

  6. XM_047428024.1XP_047283980.1  S100P-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q9H997
    UniProtKB/TrEMBL
    A0A0S2Z5M0
  7. XM_017002098.3XP_016857587.1  S100P-binding protein isoform X2

  8. XM_011541963.3XP_011540265.1  S100P-binding protein isoform X4

    See identical proteins and their annotated locations for XP_011540265.1

    Conserved Domains (1) summary
    pfam15427
    Location:22341
    S100PBPR; S100P-binding protein
  9. XM_047428038.1XP_047283994.1  S100P-binding protein isoform X5

  10. XM_047428037.1XP_047283993.1  S100P-binding protein isoform X3

  11. XM_047428039.1XP_047283995.1  S100P-binding protein isoform X6

  12. XM_047428023.1XP_047283979.1  S100P-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q9H997
    UniProtKB/TrEMBL
    A0A0S2Z5M0
  13. XM_047428040.1XP_047283996.1  S100P-binding protein isoform X2

  14. XM_024449177.2XP_024304945.1  S100P-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q9H997
    UniProtKB/TrEMBL
    A0A0S2Z5M0
    Conserved Domains (1) summary
    pfam15427
    Location:22402
    S100PBPR; S100P-binding protein
  15. XM_024449176.2XP_024304944.1  S100P-binding protein isoform X1

    UniProtKB/Swiss-Prot
    Q9H997
    UniProtKB/TrEMBL
    A0A0S2Z5M0
    Conserved Domains (1) summary
    pfam15427
    Location:22402
    S100PBPR; S100P-binding protein
  16. XM_047428041.1XP_047283997.1  S100P-binding protein isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    32677224..32718671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001017406.1: Suppressed sequence

    Description
    NM_001017406.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.