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S100PBP S100P binding protein [ Homo sapiens (human) ]

Gene ID: 64766, updated on 1-Aug-2020

Summary

Official Symbol
S100PBPprovided by HGNC
Official Full Name
S100P binding proteinprovided by HGNC
Primary source
HGNC:HGNC:25768
See related
Ensembl:ENSG00000116497 MIM:611889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S100PBPR
Summary
This gene encodes a protein that was originally identified by its interaction with S100 calcium-binding protein P. Expression of this protein has been reported to be associated with pancreatic ductal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
Expression
Broad expression in testis (RPKM 19.6), lymph node (RPKM 6.5) and 24 other tissues See more
Orthologs

Genomic context

See S100PBP in Genome Data Viewer
Location:
1p35.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (32816767..32858879)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (33282368..33324480)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8469 Neighboring gene KIAA1522 Neighboring gene tyrosyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC105378631 Neighboring gene fibronectin type III domain containing 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12903, DKFZp313K2325

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
S100P-binding protein
Names
S100P binding protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031988.1 RefSeqGene

    Range
    5001..46438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256121.1NP_001243050.1  S100P-binding protein

    See identical proteins and their annotated locations for NP_001243050.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same protein.
    Source sequence(s)
    AA557330, AK022965, AK090711, BX647916
    Consensus CDS
    CCDS30666.1
    UniProtKB/Swiss-Prot
    Q96BU1
    UniProtKB/TrEMBL
    A0A0S2Z5M0
    Related
    ENSP00000362575.1, ENST00000373476.5
    Conserved Domains (1) summary
    pfam15427
    Location:22402
    S100PBPR; S100P-binding protein
  2. NM_022753.4NP_073590.2  S100P-binding protein

    See identical proteins and their annotated locations for NP_073590.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 3 both encode the same protein.
    Source sequence(s)
    AK022965, BX647916
    Consensus CDS
    CCDS30666.1
    UniProtKB/Swiss-Prot
    Q96BU1
    UniProtKB/TrEMBL
    A0A0S2Z5M0
    Related
    ENSP00000362574.5, ENST00000373475.10
    Conserved Domains (1) summary
    pfam15427
    Location:22402
    S100PBPR; S100P-binding protein

RNA

  1. NR_135106.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction and contains two alternate exons compared to variant 1. The exon combination at the 5' UTR has not been determined. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA557330, AC114493, AK090711, BX647916, KU178751
  2. NR_135107.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon compared to variant 1. The exon combination at the 5' UTR has not been determined. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA557330, AC114493, AK022965, AK090711, BX647916

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    32816767..32858879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541962.2XP_011540264.1  S100P-binding protein isoform X1

    See identical proteins and their annotated locations for XP_011540264.1

    UniProtKB/Swiss-Prot
    Q96BU1
    UniProtKB/TrEMBL
    A0A0S2Z5M0
    Conserved Domains (1) summary
    pfam15427
    Location:22402
    S100PBPR; S100P-binding protein
  2. XM_017002098.2XP_016857587.1  S100P-binding protein isoform X2

  3. XM_011541963.2XP_011540265.1  S100P-binding protein isoform X3

    See identical proteins and their annotated locations for XP_011540265.1

    Conserved Domains (1) summary
    pfam15427
    Location:22341
    S100PBPR; S100P-binding protein
  4. XM_011541961.2XP_011540263.1  S100P-binding protein isoform X1

    See identical proteins and their annotated locations for XP_011540263.1

    UniProtKB/Swiss-Prot
    Q96BU1
    UniProtKB/TrEMBL
    A0A0S2Z5M0
    Conserved Domains (1) summary
    pfam15427
    Location:22402
    S100PBPR; S100P-binding protein
  5. XM_024449177.1XP_024304945.1  S100P-binding protein isoform X1

    Conserved Domains (1) summary
    pfam15427
    Location:22402
    S100PBPR; S100P-binding protein
  6. XM_024449175.1XP_024304943.1  S100P-binding protein isoform X1

    Conserved Domains (1) summary
    pfam15427
    Location:22402
    S100PBPR; S100P-binding protein
  7. XM_024449176.1XP_024304944.1  S100P-binding protein isoform X1

    Conserved Domains (1) summary
    pfam15427
    Location:22402
    S100PBPR; S100P-binding protein

RNA

  1. XR_001737364.2 RNA Sequence

  2. XR_946740.3 RNA Sequence

  3. XR_001737363.2 RNA Sequence

  4. XR_001737365.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001017406.1: Suppressed sequence

    Description
    NM_001017406.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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