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CREB3L2 cAMP responsive element binding protein 3 like 2 [ Homo sapiens (human) ]

Gene ID: 64764, updated on 13-Jan-2020

Summary

Official Symbol
CREB3L2provided by HGNC
Official Full Name
cAMP responsive element binding protein 3 like 2provided by HGNC
Primary source
HGNC:HGNC:23720
See related
Ensembl:ENSG00000182158 MIM:608834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BBF2H7
Summary
This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in thyroid (RPKM 36.0), placenta (RPKM 17.4) and 24 other tissues See more
Orthologs

Genomic context

See CREB3L2 in Genome Data Viewer
Location:
7q33
Exon count:
14
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (137874979..138002086, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (137559725..137686847, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene pleiotrophin Neighboring gene pleiotrophin promoter Neighboring gene diacylglycerol kinase iota Neighboring gene ribosomal protein L6 pseudogene 19 Neighboring gene CREB3L2 antisense RNA 1 Neighboring gene protein phosphatase 2 regulatory subunit B', gamma pseudogene Neighboring gene Der1-like domain family, member 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71006, MGC131709

Gene Ontology Provided by GOA

Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
cartilage development ISS
Inferred from Sequence or Structural Similarity
more info
 
chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum unfolded protein response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
response to endoplasmic reticulum stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to wounding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cyclic AMP-responsive element-binding protein 3-like protein 2
Names
B-ZIB transcription factor
BBF2 human homolog on chromosome 7
FUS/BBF2H7 protein
TCAG_1951439
basic transcription factor 2
cAMP-responsive element-binding protein 3-like protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253775.2NP_001240704.1  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and UTR compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC022173, BC063666, CN394705
    Consensus CDS
    CCDS59083.1
    UniProtKB/Swiss-Prot
    Q70SY1
    Related
    ENSP00000410314.1, ENST00000452463.5
  2. NM_001318246.1NP_001305175.1  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5'-terminal exon and a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL080209, BC015585, BX649143, CR749563
    UniProtKB/TrEMBL
    Q68D60
    Conserved Domains (1) summary
    cd14689
    Location:242285
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
  3. NM_194071.4NP_919047.2  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_919047.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC022173, AK131517, BQ711676, BX649143, CR749563
    Consensus CDS
    CCDS34760.1
    UniProtKB/Swiss-Prot
    Q70SY1
    UniProtKB/TrEMBL
    Q68D60
    Related
    ENSP00000329140.6, ENST00000330387.11
    Conserved Domains (1) summary
    cd14689
    Location:305348
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    137874979..138002086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250541.4XP_005250598.1  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005250598.1

    Conserved Domains (1) summary
    cd14689
    Location:242285
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
  2. XM_017012540.1XP_016868029.1  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1

    Conserved Domains (1) summary
    cd14689
    Location:242285
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
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