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TNS3 tensin 3 [ Homo sapiens (human) ]

Gene ID: 64759, updated on 9-Jun-2024

Summary

Official Symbol
TNS3provided by HGNC
Official Full Name
tensin 3provided by HGNC
Primary source
HGNC:HGNC:21616
See related
Ensembl:ENSG00000136205 MIM:606825; AllianceGenome:HGNC:21616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TEM6; TENS1
Summary
Predicted to enable phosphatase activity. Predicted to be involved in dephosphorylation and intracellular signal transduction. Predicted to act upstream of or within cell migration; lung alveolus development; and positive regulation of cell population proliferation. Located in cytosol and focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta (RPKM 15.0), lung (RPKM 14.4) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See TNS3 in Genome Data Viewer
Location:
7p12.3
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (47275154..47582586, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (47436453..47744868, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (47314752..47621709, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375268 Neighboring gene MPRA-validated peak6510 silencer Neighboring gene serine and arginine rich splicing factor 8C, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:47162015-47162514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25975 Neighboring gene MPRA-validated peak6511 silencer Neighboring gene uncharacterized LOC124901628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25976 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:47332661-47333860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47354649-47355451 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47366159-47366764 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:47383941-47384441 Neighboring gene uncharacterized LOC124901629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47410550-47411140 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:47411141-47411732 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:47411733-47412323 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47419203-47420066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47440071-47440980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47442727-47443235 Neighboring gene NANOG hESC enhancer GRCh37_chr7:47459035-47459536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47486948-47487448 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47510136-47510952 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47514765-47515308 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:47519651-47520334 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:47520335-47521016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47521589-47522136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47528112-47528658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47533187-47533778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47541736-47542333 Neighboring gene small nucleolar RNA, C/D box 151 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47542334-47542930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47543969-47544469 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47558749-47559460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47559461-47560172 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47560443-47560949 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47560950-47561455 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47576373-47577246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47595932-47596660 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47597389-47598116 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:47621045-47621582 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:47621583-47622120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25980 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:47650466-47650707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47653818-47654364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47654365-47654909 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:47665579-47666118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:47674273-47674984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:47699457-47699997 Neighboring gene long intergenic non-protein coding RNA 1447 Neighboring gene long intergenic non-protein coding RNA 2902

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.
EBI GWAS Catalog
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
EBI GWAS Catalog
Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ13732, FLJ35545, MGC88434, DKFZp686M1045, DKFZp686K12123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in focal adhesion HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 
located_in podosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tensin-3
Names
tensin-like SH2 domain containing 1
tensin-like SH2 domain-containing protein 1
thyroid specific PTB domain protein
tumor endothelial marker 6

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410877.1NP_001397806.1  tensin-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC073341, AC092000
    Consensus CDS
    CCDS94098.1
    UniProtKB/TrEMBL
    A0A994J537
    Related
    ENSP00000516118.1, ENST00000705350.1
  2. NM_001410878.1NP_001397807.1  tensin-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073341, AC092000
    Consensus CDS
    CCDS94100.1
    UniProtKB/TrEMBL
    E9PCX8, Q59GW4
    Related
    ENSP00000414358.2, ENST00000457718.6
  3. NM_022748.12NP_073585.8  tensin-3 isoform 3

    See identical proteins and their annotated locations for NP_073585.8

    Status: VALIDATED

    Source sequence(s)
    AC073341, AC092000, AF378756, AF417489, AK092864
    Consensus CDS
    CCDS5506.2
    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
    Related
    ENSP00000312143.9, ENST00000311160.14
    Conserved Domains (5) summary
    cd09927
    Location:11681284
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:72186
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:13081439
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6241058
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    47275154..47582586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420733.1XP_047276689.1  tensin-3 isoform X9

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
  2. XM_047420729.1XP_047276685.1  tensin-3 isoform X6

    UniProtKB/TrEMBL
    Q59GW4
  3. XM_047420724.1XP_047276680.1  tensin-3 isoform X1

  4. XM_047420731.1XP_047276687.1  tensin-3 isoform X9

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
  5. XM_047420725.1XP_047276681.1  tensin-3 isoform X3

    UniProtKB/TrEMBL
    Q59GW4
  6. XM_047420728.1XP_047276684.1  tensin-3 isoform X5

    UniProtKB/TrEMBL
    Q59GW4
  7. XM_047420723.1XP_047276679.1  tensin-3 isoform X1

  8. XM_047420730.1XP_047276686.1  tensin-3 isoform X9

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
  9. XM_047420732.1XP_047276688.1  tensin-3 isoform X9

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
  10. XM_017012537.2XP_016868026.1  tensin-3 isoform X2

    UniProtKB/TrEMBL
    Q59GW4
  11. XM_047420735.1XP_047276691.1  tensin-3 isoform X9

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
  12. XM_011515480.4XP_011513782.1  tensin-3 isoform X9

    See identical proteins and their annotated locations for XP_011513782.1

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
    Conserved Domains (5) summary
    cd09927
    Location:11681284
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:72186
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:13081439
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6241058
    Atrophin-1; Atrophin-1 family
  13. XM_011515478.3XP_011513780.1  tensin-3 isoform X7

    UniProtKB/TrEMBL
    C9JHU5, Q59GW4
    Related
    ENSP00000396914.2, ENST00000450444.6
    Conserved Domains (5) summary
    cd09927
    Location:12571373
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:161275
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:13971528
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam00130
    Location:1057
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam10409
    Location:262388
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
  14. XM_047420726.1XP_047276682.1  tensin-3 isoform X4

  15. XM_047420736.1XP_047276692.1  tensin-3 isoform X9

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
  16. XM_024446876.2XP_024302644.1  tensin-3 isoform X9

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
    Conserved Domains (5) summary
    cd09927
    Location:11681284
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:72186
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:13081439
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6241058
    Atrophin-1; Atrophin-1 family
  17. XM_047420737.1XP_047276693.1  tensin-3 isoform X9

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
  18. XM_011515481.3XP_011513783.1  tensin-3 isoform X9

    See identical proteins and their annotated locations for XP_011513783.1

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
    Conserved Domains (5) summary
    cd09927
    Location:11681284
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:72186
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:13081439
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6241058
    Atrophin-1; Atrophin-1 family
  19. XM_047420738.1XP_047276694.1  tensin-3 isoform X9

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
  20. XM_011515479.3XP_011513781.1  tensin-3 isoform X8

    Conserved Domains (4) summary
    cd09927
    Location:12111327
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:115229
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:13511482
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:216342
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
  21. XM_011515483.3XP_011513785.1  tensin-3 isoform X9

    See identical proteins and their annotated locations for XP_011513785.1

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
    Conserved Domains (5) summary
    cd09927
    Location:11681284
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:72186
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:13081439
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6241058
    Atrophin-1; Atrophin-1 family
  22. XM_011515484.4XP_011513786.1  tensin-3 isoform X10

    UniProtKB/TrEMBL
    A0A994J7F3, Q8NDL6
    Related
    ENSP00000516130.1, ENST00000705474.1
    Conserved Domains (2) summary
    cd09927
    Location:725841
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    cd01213
    Location:865996
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    47436453..47744868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358825.1XP_054214800.1  tensin-3 isoform X6

    UniProtKB/TrEMBL
    Q59GW4
  2. XM_054358830.1XP_054214805.1  tensin-3 isoform X9

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
  3. XM_054358822.1XP_054214797.1  tensin-3 isoform X3

    UniProtKB/TrEMBL
    Q59GW4
  4. XM_054358824.1XP_054214799.1  tensin-3 isoform X5

    UniProtKB/TrEMBL
    Q59GW4
  5. XM_054358820.1XP_054214795.1  tensin-3 isoform X1

  6. XM_054358828.1XP_054214803.1  tensin-3 isoform X9

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
  7. XM_054358832.1XP_054214807.1  tensin-3 isoform X9

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
  8. XM_054358821.1XP_054214796.1  tensin-3 isoform X2

    UniProtKB/TrEMBL
    Q59GW4
  9. XM_054358831.1XP_054214806.1  tensin-3 isoform X9

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
  10. XM_054358826.1XP_054214801.1  tensin-3 isoform X7

    UniProtKB/TrEMBL
    Q59GW4
  11. XM_054358823.1XP_054214798.1  tensin-3 isoform X4

  12. XM_054358833.1XP_054214808.1  tensin-3 isoform X9

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
  13. XM_054358829.1XP_054214804.1  tensin-3 isoform X9

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
  14. XM_054358834.1XP_054214809.1  tensin-3 isoform X9

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
  15. XM_054358827.1XP_054214802.1  tensin-3 isoform X8

  16. XM_054358835.1XP_054214810.1  tensin-3 isoform X9

    UniProtKB/Swiss-Prot
    B2RNV1, Q68CZ2, Q6IPQ2, Q8IZW7, Q8NAD0, Q96PE0, Q96S48
    UniProtKB/TrEMBL
    Q59GW4
  17. XM_054358836.1XP_054214811.1  tensin-3 isoform X10

    UniProtKB/TrEMBL
    A0A994J7F3, Q8NDL6