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TNS3 tensin 3 [ Homo sapiens (human) ]

Gene ID: 64759, updated on 4-Sep-2022

Summary

Official Symbol
TNS3provided by HGNC
Official Full Name
tensin 3provided by HGNC
Primary source
HGNC:HGNC:21616
See related
Ensembl:ENSG00000136205 MIM:606825; AllianceGenome:HGNC:21616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TEM6; TENS1
Summary
Predicted to enable phosphatase activity. Predicted to be involved in dephosphorylation and intracellular signal transduction. Predicted to act upstream of or within cell migration; lung alveolus development; and positive regulation of cell population proliferation. Located in cytosol and focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta (RPKM 15.0), lung (RPKM 14.4) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See TNS3 in Genome Data Viewer
Location:
7p12.3
Exon count:
47
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (47275154..47582586, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (47436453..47744371, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (47314752..47621709, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375268 Neighboring gene serine and arginine rich splicing factor 8C, pseudogene Neighboring gene uncharacterized LOC124901628 Neighboring gene uncharacterized LOC124901629 Neighboring gene small nucleolar RNA, C/D box 151 Neighboring gene long intergenic non-protein coding RNA 1447 Neighboring gene long intergenic non-protein coding RNA 2902

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.
EBI GWAS Catalog
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
EBI GWAS Catalog
Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13732, FLJ35545, MGC88434, DKFZp686M1045, DKFZp686K12123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in focal adhesion HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
tensin-3
Names
tensin-like SH2 domain containing 1
tensin-like SH2 domain-containing protein 1
thyroid specific PTB domain protein
tumor endothelial marker 6

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410877.1NP_001397806.1  tensin-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC073341, AC092000
  2. NM_001410878.1NP_001397807.1  tensin-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC073341, AC092000
  3. NM_022748.12NP_073585.8  tensin-3 isoform 3

    See identical proteins and their annotated locations for NP_073585.8

    Status: VALIDATED

    Source sequence(s)
    AC073341, AC092000, AF378756, AF417489, AK092864
    Consensus CDS
    CCDS5506.2
    UniProtKB/Swiss-Prot
    Q68CZ2, Q96S48
    Related
    ENSP00000312143.9, ENST00000311160.14
    Conserved Domains (5) summary
    cd09927
    Location:11681284
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:72186
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:13081439
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6241058
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    47275154..47582586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420733.1XP_047276689.1  tensin-3 isoform X11

    UniProtKB/Swiss-Prot
    Q96S48
  2. XM_047420729.1XP_047276685.1  tensin-3 isoform X8

  3. XM_011515477.3XP_011513779.1  tensin-3 isoform X5

    Related
    ENSP00000414358.1, ENST00000457718.5
    Conserved Domains (5) summary
    cd09927
    Location:12711387
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:175289
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:14111542
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam00130
    Location:2471
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam10409
    Location:276402
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
  4. XM_047420724.1XP_047276680.1  tensin-3 isoform X1

  5. XM_047420731.1XP_047276687.1  tensin-3 isoform X11

    UniProtKB/Swiss-Prot
    Q96S48
  6. XM_047420725.1XP_047276681.1  tensin-3 isoform X3

  7. XM_047420728.1XP_047276684.1  tensin-3 isoform X7

  8. XM_047420723.1XP_047276679.1  tensin-3 isoform X1

  9. XM_047420730.1XP_047276686.1  tensin-3 isoform X11

    UniProtKB/Swiss-Prot
    Q96S48
  10. XM_047420732.1XP_047276688.1  tensin-3 isoform X11

    UniProtKB/Swiss-Prot
    Q96S48
  11. XM_017012537.2XP_016868026.1  tensin-3 isoform X2

  12. XM_047420735.1XP_047276691.1  tensin-3 isoform X11

    UniProtKB/Swiss-Prot
    Q96S48
  13. XM_011515480.4XP_011513782.1  tensin-3 isoform X11

    See identical proteins and their annotated locations for XP_011513782.1

    UniProtKB/Swiss-Prot
    Q68CZ2, Q96S48
    Conserved Domains (5) summary
    cd09927
    Location:11681284
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:72186
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:13081439
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6241058
    Atrophin-1; Atrophin-1 family
  14. XM_011515478.3XP_011513780.1  tensin-3 isoform X9

    Conserved Domains (5) summary
    cd09927
    Location:12571373
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:161275
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:13971528
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam00130
    Location:1057
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam10409
    Location:262388
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
  15. XM_047420726.1XP_047276682.1  tensin-3 isoform X6

  16. XM_017012538.2XP_016868027.1  tensin-3 isoform X4

  17. XM_047420736.1XP_047276692.1  tensin-3 isoform X11

    UniProtKB/Swiss-Prot
    Q96S48
  18. XM_024446876.2XP_024302644.1  tensin-3 isoform X11

    UniProtKB/Swiss-Prot
    Q96S48
    Conserved Domains (5) summary
    cd09927
    Location:11681284
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:72186
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:13081439
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6241058
    Atrophin-1; Atrophin-1 family
  19. XM_047420737.1XP_047276693.1  tensin-3 isoform X11

    UniProtKB/Swiss-Prot
    Q96S48
  20. XM_011515481.3XP_011513783.1  tensin-3 isoform X11

    See identical proteins and their annotated locations for XP_011513783.1

    UniProtKB/Swiss-Prot
    Q68CZ2, Q96S48
    Conserved Domains (5) summary
    cd09927
    Location:11681284
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:72186
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:13081439
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6241058
    Atrophin-1; Atrophin-1 family
  21. XM_047420738.1XP_047276694.1  tensin-3 isoform X11

    UniProtKB/Swiss-Prot
    Q96S48
  22. XM_011515479.3XP_011513781.1  tensin-3 isoform X10

    Conserved Domains (4) summary
    cd09927
    Location:12111327
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:115229
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd01213
    Location:13511482
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:216342
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
  23. XM_011515483.3XP_011513785.1  tensin-3 isoform X11

    See identical proteins and their annotated locations for XP_011513785.1

    UniProtKB/Swiss-Prot
    Q68CZ2, Q96S48
    Conserved Domains (5) summary
    cd09927
    Location:11681284
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00012
    Location:72186
    PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity
    cd01213
    Location:13081439
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:173299
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl26464
    Location:6241058
    Atrophin-1; Atrophin-1 family
  24. XM_011515484.4XP_011513786.1  tensin-3 isoform X12

    Conserved Domains (2) summary
    cd09927
    Location:725841
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    cd01213
    Location:865996
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    47436453..47744371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)