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ANHX anomalous homeobox [ Homo sapiens (human) ]

Gene ID: 647589, updated on 25-Jan-2022

Summary

Official Symbol
ANHXprovided by HGNC
Official Full Name
anomalous homeoboxprovided by HGNC
Primary source
HGNC:HGNC:40024
See related
Ensembl:ENSG00000227059 AllianceGenome:HGNC:40024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in eye development and regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward testis (RPKM 2.0) See more
Orthologs
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Genomic context

See ANHX in Genome Data Viewer
Location:
12q24.33
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (133218312..133236133, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133794898..133812463, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 10 Neighboring gene zinc finger protein 268 Neighboring gene RNA, U6 small nuclear 717, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in eye development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191054.1NP_001177983.1  anomalous homeobox protein isoform 2

    See identical proteins and their annotated locations for NP_001177983.1

    Status: VALIDATED

    Source sequence(s)
    AC226150, AK057223, DB032853
    Consensus CDS
    CCDS53855.1
    UniProtKB/Swiss-Prot
    E9PGG2
    Related
    ENSP00000409950.1, ENST00000419717.3
    Conserved Domains (2) summary
    cd00086
    Location:139193
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam16878
    Location:79130
    SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain
  2. NM_001372060.1NP_001358989.1  anomalous homeobox protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC226150
    Related
    ENSP00000439513.2, ENST00000545940.6
    Conserved Domains (2) summary
    cd00086
    Location:139193
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam16878
    Location:79130
    SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    133218312..133236133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534822.3XP_011533124.1  anomalous homeobox protein isoform X3

    Conserved Domains (2) summary
    cd00086
    Location:139193
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam16878
    Location:79130
    SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain
  2. XM_006719743.4XP_006719806.1  anomalous homeobox protein isoform X1

    See identical proteins and their annotated locations for XP_006719806.1

    Conserved Domains (2) summary
    cd00086
    Location:139193
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam16878
    Location:79130
    SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain
  3. XM_011534818.2XP_011533120.1  anomalous homeobox protein isoform X1

    See identical proteins and their annotated locations for XP_011533120.1

    Conserved Domains (2) summary
    cd00086
    Location:139193
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam16878
    Location:79130
    SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain
  4. XM_011534825.2XP_011533127.1  anomalous homeobox protein isoform X5

    Conserved Domains (2) summary
    cd00086
    Location:139193
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam16878
    Location:79130
    SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain
  5. XM_011534823.2XP_011533125.1  anomalous homeobox protein isoform X4

    See identical proteins and their annotated locations for XP_011533125.1

    Conserved Domains (2) summary
    cd00086
    Location:139193
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam16878
    Location:79130
    SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain
  6. XM_011534824.2XP_011533126.1  anomalous homeobox protein isoform X4

    See identical proteins and their annotated locations for XP_011533126.1

    Conserved Domains (2) summary
    cd00086
    Location:139193
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam16878
    Location:79130
    SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain

RNA

  1. XR_941396.2 RNA Sequence

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