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MTARC1 mitochondrial amidoxime reducing component 1 [ Homo sapiens (human) ]

Gene ID: 64757, updated on 22-Sep-2022

Summary

Official Symbol
MTARC1provided by HGNC
Official Full Name
mitochondrial amidoxime reducing component 1provided by HGNC
Primary source
HGNC:HGNC:26189
See related
Ensembl:ENSG00000186205 MIM:614126; AllianceGenome:HGNC:26189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MARC1; MOSC1
Summary
Enables molybdenum ion binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on other nitrogenous compounds as donors. Contributes to nitrite reductase (NO-forming) activity. Involved in cellular detoxification of nitrogen compound; nitrate metabolic process; and nitric oxide biosynthetic process. Located in mitochondrion. Part of nitric-oxide synthase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in fat (RPKM 66.4), thyroid (RPKM 15.8) and 6 other tissues See more
Orthologs
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Genomic context

See MTARC1 in Genome Data Viewer
Location:
1q41
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (220786913..220819659)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (220026620..220059373)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (220960255..220993001)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904516 Neighboring gene mitochondrial amidoxime reducing component 2 Neighboring gene Sharpr-MPRA regulatory region 12019 Neighboring gene RNA, U6atac small nuclear 35, pseudogene Neighboring gene U6atac minor spliceosomal RNA Neighboring gene long intergenic non-protein coding RNA 1352

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Genetic and clinical correlates of early-outgrowth colony-forming units.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22390

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molybdenum ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molybdenum ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables molybdopterin cofactor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables molybdopterin cofactor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nitrate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nitrate reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to nitrite reductase (NO-forming) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nitrite reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidoreductase activity, acting on other nitrogenous compounds as donors IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of nitric-oxide synthase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitochondrial amidoxime-reducing component 1
Names
MOCO sulphurase C-terminal domain containing 1
MOSC domain-containing protein 1, mitochondrial
moco sulfurase C-terminal domain-containing protein 1
molybdenum cofactor sulfurase C-terminal domain-containing protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022746.4NP_073583.3  mitochondrial amidoxime-reducing component 1 precursor

    See identical proteins and their annotated locations for NP_073583.3

    Status: VALIDATED

    Source sequence(s)
    AK290812, AL445423, CA439234, CB048738, DA878171
    Consensus CDS
    CCDS1526.1
    UniProtKB/Swiss-Prot
    Q5VT66, Q9H6C7
    Related
    ENSP00000355877.5, ENST00000366910.10
    Conserved Domains (3) summary
    COG3217
    Location:57335
    YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]
    pfam03473
    Location:204333
    MOSC; MOSC domain
    pfam03476
    Location:55176
    MOSC_N; MOSC N-terminal beta barrel domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    220786913..220819659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509900.4XP_011508202.1  mitochondrial amidoxime-reducing component 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5VT66
    Conserved Domains (3) summary
    COG3217
    Location:57352
    YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]
    pfam03473
    Location:204350
    MOSC; MOSC domain
    pfam03476
    Location:55176
    MOSC_N; MOSC N-terminal beta barrel domain
  2. XM_011509904.4XP_011508206.1  mitochondrial amidoxime-reducing component 1 isoform X4

    UniProtKB/Swiss-Prot
    Q5VT66
    Related
    ENSP00000385327.2, ENST00000407981.6
    Conserved Domains (2) summary
    pfam03473
    Location:102248
    MOSC; MOSC domain
    pfam03476
    Location:174
    MOSC_N; MOSC N-terminal beta barrel domain
  3. XM_011509903.4XP_011508205.1  mitochondrial amidoxime-reducing component 1 isoform X2

    Conserved Domains (2) summary
    pfam03473
    Location:121267
    MOSC; MOSC domain
    pfam03476
    Location:793
    MOSC_N; MOSC N-terminal beta barrel domain
  4. XM_017002096.3XP_016857585.1  mitochondrial amidoxime-reducing component 1 isoform X3

    Related
    ENSP00000511593.1, ENST00000694918.1

RNA

  1. XR_001737362.2 RNA Sequence

  2. XR_921908.2 RNA Sequence

  3. XR_007063025.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    220026620..220059373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)