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MTARC1 mitochondrial amidoxime reducing component 1 [ Homo sapiens (human) ]

Gene ID: 64757, updated on 1-Jun-2020

Summary

Official Symbol
MTARC1provided by HGNC
Official Full Name
mitochondrial amidoxime reducing component 1provided by HGNC
Primary source
HGNC:HGNC:26189
See related
Ensembl:ENSG00000186205 MIM:614126
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MARC1; MOSC1
Expression
Biased expression in fat (RPKM 66.4), thyroid (RPKM 15.8) and 6 other tissues See more
Orthologs

Genomic context

See MTARC1 in Genome Data Viewer
Location:
1q41
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (220786697..220819659)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (220960039..220987741)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 115 Neighboring gene mitochondrial amidoxime reducing component 2 Neighboring gene RNA, U6atac small nuclear 35, pseudogene Neighboring gene long intergenic non-protein coding RNA 1352

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genetic and clinical correlates of early-outgrowth colony-forming units.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22390

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molybdenum ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molybdenum ion binding IDA
Inferred from Direct Assay
more info
PubMed 
molybdopterin cofactor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molybdopterin cofactor binding IDA
Inferred from Direct Assay
more info
PubMed 
nitrate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nitrate reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
detoxification of nitrogen compound NAS
Non-traceable Author Statement
more info
PubMed 
nitrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nitrate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
mitochondrial amidoxime-reducing component 1
Names
MOCO sulphurase C-terminal domain containing 1
MOSC domain-containing protein 1, mitochondrial
moco sulfurase C-terminal domain-containing protein 1
molybdenum cofactor sulfurase C-terminal domain-containing protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022746.4NP_073583.3  mitochondrial amidoxime-reducing component 1 precursor

    See identical proteins and their annotated locations for NP_073583.3

    Status: VALIDATED

    Source sequence(s)
    AK290812, AL445423, CA439234, CB048738, DA878171
    Consensus CDS
    CCDS1526.1
    UniProtKB/Swiss-Prot
    Q5VT66
    Related
    ENSP00000355877.5, ENST00000366910.10
    Conserved Domains (3) summary
    COG3217
    Location:57335
    YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]
    pfam03473
    Location:204333
    MOSC; MOSC domain
    pfam03476
    Location:55176
    MOSC_N; MOSC N-terminal beta barrel domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    220786697..220819659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509900.3XP_011508202.1  mitochondrial amidoxime-reducing component 1 isoform X1

    UniProtKB/Swiss-Prot
    Q5VT66
    Conserved Domains (3) summary
    COG3217
    Location:57352
    YcbX; Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains [General function prediction only]
    pfam03473
    Location:204350
    MOSC; MOSC domain
    pfam03476
    Location:55176
    MOSC_N; MOSC N-terminal beta barrel domain
  2. XM_011509904.3XP_011508206.1  mitochondrial amidoxime-reducing component 1 isoform X4

    UniProtKB/Swiss-Prot
    Q5VT66
    Related
    ENSP00000385327.2, ENST00000407981.6
    Conserved Domains (2) summary
    pfam03473
    Location:102248
    MOSC; MOSC domain
    pfam03476
    Location:174
    MOSC_N; MOSC N-terminal beta barrel domain
  3. XM_017002097.2XP_016857586.1  mitochondrial amidoxime-reducing component 1 isoform X5

  4. XM_011509903.3XP_011508205.1  mitochondrial amidoxime-reducing component 1 isoform X2

    Conserved Domains (2) summary
    pfam03473
    Location:121267
    MOSC; MOSC domain
    pfam03476
    Location:793
    MOSC_N; MOSC N-terminal beta barrel domain
  5. XM_017002096.2XP_016857585.1  mitochondrial amidoxime-reducing component 1 isoform X3

RNA

  1. XR_001737362.1 RNA Sequence

  2. XR_921908.1 RNA Sequence

  3. XR_002957377.1 RNA Sequence

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