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PLPPR2 phospholipid phosphatase related 2 [ Homo sapiens (human) ]

Gene ID: 64748, updated on 4-Nov-2022

Summary

Official Symbol
PLPPR2provided by HGNC
Official Full Name
phospholipid phosphatase related 2provided by HGNC
Primary source
HGNC:HGNC:29566
See related
Ensembl:ENSG00000105520 MIM:619591; AllianceGenome:HGNC:29566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRG4; LPPR2
Summary
Predicted to enable lipid phosphatase activity and phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 26.0), prostate (RPKM 12.8) and 25 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See PLPPR2 in Genome Data Viewer
Location:
19p13.2
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11355432..11365698)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11482410..11492670)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11466108..11476374)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 205 Neighboring gene coiled-coil domain containing 159 Neighboring gene SWIM-type zinc finger 7 associated protein 1 Neighboring gene erythropoietin receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13055, DKFZp761E1121

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phospholipid phosphatase-related protein type 2
Names
inactive phospholipid phosphatase PLPPR2
lipid phosphate phosphatase-related protein type 2
plasticity related gene 4
plasticity-related gene 4 protein
NP_001164106.1
NP_001380821.1
NP_001380822.1
NP_001380823.1
NP_001380824.1
NP_001380825.1
NP_073574.2
XP_016882637.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170635.2NP_001164106.1  phospholipid phosphatase-related protein type 2 isoform 2

    See identical proteins and their annotated locations for NP_001164106.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AK094869, BC009378, DB169285
    Consensus CDS
    CCDS59352.1
    UniProtKB/Swiss-Prot
    Q96GM1
    Related
    ENSP00000466898.1, ENST00000591608.2
    Conserved Domains (1) summary
    cd03384
    Location:100256
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
  2. NM_001393892.1NP_001380821.1  phospholipid phosphatase-related protein type 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC024575
    Consensus CDS
    CCDS92519.1
    UniProtKB/TrEMBL
    A0A8I5KWF3
    Related
    ENSP00000510269.1, ENST00000688289.1
    Conserved Domains (1) summary
    cd03384
    Location:125281
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
  3. NM_001393893.1NP_001380822.1  phospholipid phosphatase-related protein type 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC024575
    Consensus CDS
    CCDS92519.1
    UniProtKB/TrEMBL
    A0A8I5KWF3
    Conserved Domains (1) summary
    cd03384
    Location:125281
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
  4. NM_001393894.1NP_001380823.1  phospholipid phosphatase-related protein type 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC024575
    Consensus CDS
    CCDS12258.1
    UniProtKB/Swiss-Prot
    Q9H929
    UniProtKB/TrEMBL
    A0A024R7E2
    Conserved Domains (1) summary
    cd03384
    Location:125281
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
  5. NM_001393895.1NP_001380824.1  phospholipid phosphatase-related protein type 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC024575
    Conserved Domains (1) summary
    cd03384
    Location:100256
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
  6. NM_001393896.1NP_001380825.1  phospholipid phosphatase-related protein type 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC024575
  7. NM_022737.3NP_073574.2  phospholipid phosphatase-related protein type 2 isoform 1

    See identical proteins and their annotated locations for NP_073574.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AK023117, AY304516, BC009378
    Consensus CDS
    CCDS12258.1
    UniProtKB/Swiss-Prot
    Q96GM1, Q9H929
    UniProtKB/TrEMBL
    A0A024R7E2
    Related
    ENSP00000251473.4, ENST00000251473.9
    Conserved Domains (1) summary
    cd03384
    Location:125281
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11355432..11365698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027148.2XP_016882637.1  phospholipid phosphatase-related protein type 2 isoform X1

    UniProtKB/Swiss-Prot
    Q96GM1
    Conserved Domains (1) summary
    cd03384
    Location:100256
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    11482410..11492670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)