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ACBD3 acyl-CoA binding domain containing 3 [ Homo sapiens (human) ]

Gene ID: 64746, updated on 1-Jun-2020

Summary

Official Symbol
ACBD3provided by HGNC
Official Full Name
acyl-CoA binding domain containing 3provided by HGNC
Primary source
HGNC:HGNC:15453
See related
Ensembl:ENSG00000182827 MIM:606809
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAP7; GCP60; GOCAP1; GOLPH1
Summary
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 19.9), esophagus (RPKM 18.2) and 25 other tissues See more
Orthologs

Genomic context

See ACBD3 in Genome Data Viewer
Location:
1q42.12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (226144679..226186741, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (226332380..226374423, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1703 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8-like Neighboring gene ACBD3 antisense RNA 1 Neighboring gene uncharacterized LOC101927247 Neighboring gene ribosomal protein L34 pseudogene 7 Neighboring gene Mix paired-like homeobox

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with acyl-CoA binding domain containing 3 (ACBD3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of acyl-CoA binding domain containing 3 (ACBD3) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fatty-acyl-CoA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A regulatory subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Golgi resident protein GCP60
Names
PBR- and PKA-associated protein 7
PKA (RIalpha)-associated protein
acyl-Coenzyme A binding domain containing 3
golgi complex associated protein 1, 60kDa
golgi phosphoprotein 1
peripheral benzodiazepine receptor-associated protein PAP7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028985.1 RefSeqGene

    Range
    4982..47044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022735.4NP_073572.2  Golgi resident protein GCP60

    See identical proteins and their annotated locations for NP_073572.2

    Status: REVIEWED

    Source sequence(s)
    AL592045
    Consensus CDS
    CCDS1551.1
    UniProtKB/Swiss-Prot
    Q9H3P7
    UniProtKB/TrEMBL
    A0A024R3P9
    Related
    ENSP00000355777.5, ENST00000366812.6
    Conserved Domains (2) summary
    pfam00887
    Location:84170
    ACBP; Acyl CoA binding protein
    pfam13897
    Location:397527
    GOLD_2; Golgi-dynamics membrane-trafficking

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    226144679..226186741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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