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METTL17 methyltransferase like 17 [ Homo sapiens (human) ]

Gene ID: 64745, updated on 7-Jun-2020

Summary

Official Symbol
METTL17provided by HGNC
Official Full Name
methyltransferase like 17provided by HGNC
Primary source
HGNC:HGNC:19280
See related
Ensembl:ENSG00000165792 MIM:616091
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
METT11D1
Expression
Ubiquitous expression in duodenum (RPKM 22.3), lymph node (RPKM 19.6) and 25 other tissues See more
Orthologs

Genomic context

See METTL17 in Genome Data Viewer
Location:
14q11.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (20989980..20997035)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21457432..21465194)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 189, pseudogene Neighboring gene coiled-coil domain containing 107 pseudogene Neighboring gene uncharacterized LOC101929718 Neighboring gene solute carrier family 39 member 2 Neighboring gene NDRG family member 2 Neighboring gene microRNA 6717

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20859

Gene Ontology Provided by GOA

Function Evidence Code Pubs
methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
methylation IEA
Inferred from Electronic Annotation
more info
 
translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
ribosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
methyltransferase-like protein 17, mitochondrial
Names
false p73 target gene protein
methyltransferase 11 domain containing 1
methyltransferase 11 domain-containing protein 1
protein RSM22 homolog, mitochondrial

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029991.2NP_001025162.1  methyltransferase-like protein 17, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_001025162.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AK024512, AL355922
    Consensus CDS
    CCDS41913.1
    UniProtKB/Swiss-Prot
    Q9H7H0
    Related
    ENSP00000372445.4, ENST00000382985.8
    Conserved Domains (2) summary
    COG0500
    Location:191297
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    cl17173
    Location:155421
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_022734.3NP_073571.1  methyltransferase-like protein 17, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_073571.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 3' coding region, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK024512, AL355922, BC005053
    Consensus CDS
    CCDS9562.1
    UniProtKB/Swiss-Prot
    Q9H7H0
    UniProtKB/TrEMBL
    A0A0S2Z5L8
    Related
    ENSP00000343041.6, ENST00000339374.10
    Conserved Domains (2) summary
    COG0500
    Location:191297
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    cl17173
    Location:155438
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    20989980..20997035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021601.2XP_016877090.1  methyltransferase-like protein 17, mitochondrial isoform X2

  2. XM_006720236.3XP_006720299.1  methyltransferase-like protein 17, mitochondrial isoform X1

    Conserved Domains (2) summary
    COG0500
    Location:33139
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    cl17173
    Location:2263
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001029992.1: Suppressed sequence

    Description
    NM_001029992.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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