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WDR13 WD repeat domain 13 [ Homo sapiens (human) ]

Gene ID: 64743, updated on 21-Dec-2019

Summary

Official Symbol
WDR13provided by HGNC
Official Full Name
WD repeat domain 13provided by HGNC
Primary source
HGNC:HGNC:14352
See related
Ensembl:ENSG00000101940 MIM:300512
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MG21
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. A similar protein in mouse is thought to be a negative regulator of the pancreatic beta cell proliferation. Mice lacking this gene exhibit increased pancreatic islet mass and higher serum insulin levels, and are mildly obese. [provided by RefSeq, Nov 2016]
Expression
Ubiquitous expression in ovary (RPKM 22.5), kidney (RPKM 22.5) and 25 other tissues See more
Orthologs

Genomic context

See WDR13 in Genome Data Viewer
Location:
Xp11.23
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (48590053..48608869)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48455880..48463582)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 3 Neighboring gene mitochondrial ribosomal protein L32 pseudogene 1 Neighboring gene uncharacterized LOC107985695 Neighboring gene vomeronasal 1 receptor 110 pseudogene Neighboring gene WASP actin nucleation promoting factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20563, DKFZp779C2057

Gene Ontology Provided by GOA

Function Evidence Code Pubs
promoter-specific chromatin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of type B pancreatic cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centriolar satellite IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
WD repeat-containing protein 13

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015879.1 RefSeqGene

    Range
    4987..12703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001166426.3NP_001159898.1  WD repeat-containing protein 13 isoform 2

    See identical proteins and their annotated locations for NP_001159898.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains different sequence for part of its 5' UTR which results in translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1. Variants 2 and 5 encode the same isoform.
    Source sequence(s)
    AC115618, AF158978, BC080579, DQ907253
    UniProtKB/Swiss-Prot
    Q9H1Z4
    Conserved Domains (2) summary
    sd00039
    Location:129166
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:83389
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001347217.2NP_001334146.1  WD repeat-containing protein 13 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AC115618, DQ907253, KF459106
    Consensus CDS
    CCDS14302.1
    UniProtKB/Swiss-Prot
    Q9H1Z4
    Related
    ENSP00000365919.5, ENST00000376729.10
    Conserved Domains (2) summary
    sd00039
    Location:221258
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:175481
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001347219.2NP_001334148.1  WD repeat-containing protein 13 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: Variants 2 and 5 encode the same isoform (2).
    Source sequence(s)
    AC115618, DQ907253, KF459106
    UniProtKB/Swiss-Prot
    Q9H1Z4
    Conserved Domains (2) summary
    sd00039
    Location:129166
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:83389
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_017883.6NP_060353.2  WD repeat-containing protein 13 isoform 1

    See identical proteins and their annotated locations for NP_060353.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1). Variants 1 and 4 encode the same isoform.
    Source sequence(s)
    AC115618, AF329819, BC080579, BI554303, DQ907253
    Consensus CDS
    CCDS14302.1
    UniProtKB/Swiss-Prot
    Q9H1Z4
    Related
    ENSP00000218056.5, ENST00000218056.9
    Conserved Domains (2) summary
    sd00039
    Location:221258
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:175481
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_029427.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in its 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC115618, AF329819, BC067094, BI554303, DQ907253

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    48590053..48608869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452424.1XP_024308192.1  WD repeat-containing protein 13 isoform X2

    Conserved Domains (2) summary
    sd00039
    Location:129166
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:83389
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_011543947.2XP_011542249.1  WD repeat-containing protein 13 isoform X1

    See identical proteins and their annotated locations for XP_011542249.1

    UniProtKB/Swiss-Prot
    Q9H1Z4
    Conserved Domains (2) summary
    sd00039
    Location:221258
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:175481
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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