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GMNC geminin coiled-coil domain containing [ Homo sapiens (human) ]

Gene ID: 647309, updated on 8-Dec-2022

Summary

Official Symbol
GMNCprovided by HGNC
Official Full Name
geminin coiled-coil domain containingprovided by HGNC
Primary source
HGNC:HGNC:40049
See related
Ensembl:ENSG00000205835 MIM:614448; AllianceGenome:HGNC:40049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GEMC1
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in DNA replication; negative regulation of DNA replication; and negative regulation of cell cycle. Predicted to act upstream of or within cilium assembly. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See GMNC in Genome Data Viewer
Location:
3q28
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (190843271..190862694, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (193669068..193679021, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (190570526..190580483, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1 subunit 6 pseudogene 4 Neighboring gene ENAH pseudogene 1 Neighboring gene small NF90 (ILF3) associated RNA I Neighboring gene uncharacterized LOC107986171

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • DKFZp434B153, DKFZp781J1746

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
geminin coiled-coil domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146686.3NP_001140158.1  geminin coiled-coil domain-containing protein 1

    See identical proteins and their annotated locations for NP_001140158.1

    Status: VALIDATED

    Source sequence(s)
    AC092952
    Consensus CDS
    CCDS54697.1
    UniProtKB/Swiss-Prot
    A6NCL1
    Related
    ENSP00000406164.1, ENST00000442080.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    190843271..190862694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_924161.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    193669068..193679021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)