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UNKL unk like zinc finger [ Homo sapiens (human) ]

Gene ID: 64718, updated on 23-Nov-2021

Summary

Official Symbol
UNKLprovided by HGNC
Official Full Name
unk like zinc fingerprovided by HGNC
Primary source
HGNC:HGNC:14184
See related
Ensembl:ENSG00000059145 MIM:617463
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZC3H5L; C16orf28; ZC3HDC5L
Summary
This gene encodes a RING finger protein that may function in Rac signaling. It can bind to Brg/Brm-associated factor 60b and can promote its ubiquitination. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in ovary (RPKM 4.2), endometrium (RPKM 4.2) and 25 other tissues See more
Orthologs
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Genomic context

See UNKL in Genome Data Viewer
Location:
16p13.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (1363205..1414749, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1413206..1464705, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S20 pseudogene 2 Neighboring gene BAI1 associated protein 3 Neighboring gene TSR3 ribosome maturation factor Neighboring gene N-acetylglucosamine-1-phosphate transferase subunit gamma Neighboring gene tight junction protein 1 pseudogene 1 Neighboring gene uncharacterized LOC101929440 Neighboring gene nonconserved acetylation island sequence 122 enhancer Neighboring gene chromosome 16 open reading frame 91

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5179, FLJ12623, FLJ23360, KIAA0734

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative E3 ubiquitin-protein ligase UNKL
Names
RING finger protein unkempt-like
unkempt family zinc finger-like
unkempt homolog-like
zinc finger CCCH domain-containing protein 5-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033129.1 RefSeqGene

    Range
    5001..56500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001037125.4NP_001032202.1  putative E3 ubiquitin-protein ligase UNKL isoform 2

    See identical proteins and their annotated locations for NP_001032202.1

    Status: REVIEWED

    Source sequence(s)
    AL031721, AL032819
    Consensus CDS
    CCDS32359.1
    UniProtKB/Swiss-Prot
    Q9H9P5
    Related
    ENSP00000301712.5, ENST00000301712.5
    Conserved Domains (1) summary
    pfam18384
    Location:2560
    zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)
  2. NM_001193388.4NP_001180317.2  putative E3 ubiquitin-protein ligase UNKL isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721, AL032819
    UniProtKB/Swiss-Prot
    Q9H9P5
    UniProtKB/TrEMBL
    A0A0A0MRZ1
    Related
    ENSP00000422852.3, ENST00000508903.7
    Conserved Domains (3) summary
    pfam00642
    Location:286312
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam11825
    Location:462533
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1
    pfam13920
    Location:640677
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  3. NM_001193389.2NP_001180318.1  putative E3 ubiquitin-protein ligase UNKL isoform 4

    See identical proteins and their annotated locations for NP_001180318.1

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721
    Consensus CDS
    CCDS53980.1
    UniProtKB/Swiss-Prot
    Q9H9P5
    Related
    ENSP00000501444.1, ENST00000674376.1
    Conserved Domains (1) summary
    pfam13920
    Location:139176
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  4. NM_001276414.2NP_001263343.1  putative E3 ubiquitin-protein ligase UNKL isoform 5

    See identical proteins and their annotated locations for NP_001263343.1

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721
    Consensus CDS
    CCDS61787.1
    UniProtKB/Swiss-Prot
    Q9H9P5
    Related
    ENSP00000248104.7, ENST00000248104.11
    Conserved Domains (1) summary
    pfam13920
    Location:186223
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  5. NM_001367622.1NP_001354551.1  putative E3 ubiquitin-protein ligase UNKL isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721
  6. NM_001370526.1NP_001357455.1  putative E3 ubiquitin-protein ligase UNKL isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721
    Conserved Domains (1) summary
    pfam03962
    Location:75143
    Mnd1; Mnd1 family
  7. NM_001372107.1NP_001359036.1  putative E3 ubiquitin-protein ligase UNKL isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721, AL032819
    Related
    ENSP00000373873.6, ENST00000389221.9
    Conserved Domains (5) summary
    pfam04012
    Location:569699
    PspA_IM30; PspA/IM30 family
    cd16772
    Location:690727
    RING-HC_UNKL; RING finger, HC subclass, found in RING finger protein unkempt-like (UNKL) and similar proteins
    pfam00642
    Location:286311
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam02161
    Location:442534
    Prog_receptor; Progesterone receptor
    pfam18384
    Location:2560
    zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)

RNA

  1. NR_160278.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721, AL032819
  2. NR_160279.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721
  3. NR_160280.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721
  4. NR_163466.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721
    Related
    ENST00000403703.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    1363205..1414749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522611.1XP_011520913.1  putative E3 ubiquitin-protein ligase UNKL isoform X3

    Conserved Domains (3) summary
    pfam00642
    Location:306332
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam11825
    Location:482553
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1
    pfam13920
    Location:660697
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  2. XM_011522610.1XP_011520912.1  putative E3 ubiquitin-protein ligase UNKL isoform X1

    Conserved Domains (4) summary
    pfam00642
    Location:306332
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam11825
    Location:482553
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1
    pfam13863
    Location:589663
    DUF4200; Domain of unknown function (DUF4200)
    pfam13920
    Location:710747
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  3. XM_011522612.1XP_011520914.1  putative E3 ubiquitin-protein ligase UNKL isoform X4

    Conserved Domains (3) summary
    pfam00642
    Location:236262
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13863
    Location:519593
    DUF4200; Domain of unknown function (DUF4200)
    pfam13920
    Location:640677
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  4. XM_017023569.1XP_016879058.1  putative E3 ubiquitin-protein ligase UNKL isoform X6

    UniProtKB/Swiss-Prot
    Q9H9P5
    Conserved Domains (1) summary
    pfam13920
    Location:189226
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
  5. XM_011522613.1XP_011520915.1  putative E3 ubiquitin-protein ligase UNKL isoform X5

    Conserved Domains (1) summary
    pfam00642
    Location:306332
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

RNA

  1. XR_932901.1 RNA Sequence

  2. XR_002957834.1 RNA Sequence

  3. XR_001751965.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024023.1: Suppressed sequence

    Description
    NM_024023.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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