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PDIA2 protein disulfide isomerase family A member 2 [ Homo sapiens (human) ]

Gene ID: 64714, updated on 2-Mar-2021

Summary

Official Symbol
PDIA2provided by HGNC
Official Full Name
protein disulfide isomerase family A member 2provided by HGNC
Primary source
HGNC:HGNC:14180
See related
Ensembl:ENSG00000185615 MIM:608012
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDI; PDA2; PDIP; PDIR
Summary
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels. [provided by RefSeq, Sep 2017]
Expression
Biased expression in pancreas (RPKM 284.3) and stomach (RPKM 33.5) See more
Orthologs
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Genomic context

See PDIA2 in Genome Data Viewer
Location:
16p13.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (283164..287215)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (333164..337215)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 234 member A Neighboring gene regulator of G protein signaling 11 Neighboring gene Rho GDP dissociation inhibitor gamma Neighboring gene axin 1 Neighboring gene Sharpr-MPRA regulatory region 4309 Neighboring gene mitochondrial ribosomal protein L28

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 co-localizes with the endoplasmic reticulum protein PDI in HIV-transfected 293T cells PubMed
env PDI is predominantly involved in HIV-1 entry and infection of the T cell line PM-1 and PHA-stimulated primary T lymphocytes, suggesting the preferential use of PDI relevant to the HIV-1 entry and establishment of virus reservoirs in resting CD4+ cells PubMed
env Protein-disulfide isomerase (PDI) cleaves disulfide bonds in recombinant HIV-1 envelope glycoprotein gp120, and gp120 bound to the surface receptor CD4 undergoes a disulfide reduction that is prevented by PDI inhibitors PubMed
env The disulfide cross-linking interaction between gp120 and PDI is enhanced by CD4 protein PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with PDIA2; predicted interaction to be within the endoplasmic reticulum and function as thioredoxin reductase PubMed
env HIV-1 gp160 co-localizes with the endoplasmic reticulum protein PDI in HIV-transfected 293T cells PubMed
env Treatment of trimeric HIV-1 rgp140 with protein disulfide isomerase yields monomers by disruption of the intermolecular disulfide bonds PubMed
env HIV-1 gp160 C1, V1/V2, and the CD4-binding domains are required for its binding to protein-disulfide isomerase (PDI) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
disulfide oxidoreductase activity TAS
Traceable Author Statement
more info
PubMed 
peptide disulfide oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein disulfide isomerase activity IEA
Inferred from Electronic Annotation
more info
 
steroid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein folding in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
protein phosphopantetheinylation IEA
Inferred from Electronic Annotation
more info
 
protein retention in ER lumen TAS
Traceable Author Statement
more info
PubMed 
response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein disulfide-isomerase A2
Names
Rho GDP dissociation inhibitor gamma
pancreas-specific protein disulfide isomerase
pancreatic protein disulfide isomerase
protein disulfide isomerase, pancreatic
protein disulfide isomerase-associated 2
NP_006840.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006849.4NP_006840.2  protein disulfide-isomerase A2 precursor

    See identical proteins and their annotated locations for NP_006840.2

    Status: REVIEWED

    Source sequence(s)
    Z69667
    Consensus CDS
    CCDS42089.1
    UniProtKB/Swiss-Prot
    Q13087
    Related
    ENSP00000219406.6, ENST00000219406.10
    Conserved Domains (5) summary
    cd02981
    Location:157254
    PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
    cd02982
    Location:259368
    PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
    cd02995
    Location:389491
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    TIGR01130
    Location:42497
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
    cl00388
    Location:62151
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    283164..287215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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