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HS3ST6 heparan sulfate-glucosamine 3-sulfotransferase 6 [ Homo sapiens (human) ]

Gene ID: 64711, updated on 13-Mar-2020

Summary

Official Symbol
HS3ST6provided by HGNC
Official Full Name
heparan sulfate-glucosamine 3-sulfotransferase 6provided by HGNC
Primary source
HGNC:HGNC:14178
See related
Ensembl:ENSG00000162040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HS3ST5; 3-OST-6
Expression
Biased expression in skin (RPKM 2.3), placenta (RPKM 0.2) and 1 other tissue See more
Orthologs

Genomic context

See HS3ST6 in Genome Data Viewer
Location:
16p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (1911475..1921428, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1961464..1968231, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 254 Neighboring gene long intergenic non-protein coding RNA 2124 Neighboring gene methionine sulfoxide reductase B1 Neighboring gene ribosomal protein L3 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
blastocyst hatching IEA
Inferred from Electronic Annotation
more info
 
glycosaminoglycan biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 6
Names
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
heparan sulfate (glucosamine) 3-O-sulfotransferase 6
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6
heparan sulphate D-glucosaminyl 3-O-sulfotransferase-3B like
NP_001009606.3
XP_011520910.1
XP_011520911.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009606.4NP_001009606.3  heparan sulfate glucosamine 3-O-sulfotransferase 6

    See identical proteins and their annotated locations for NP_001009606.3

    Status: VALIDATED

    Source sequence(s)
    AL031723, CK300523, DY654407
    Consensus CDS
    CCDS45381.2
    UniProtKB/Swiss-Prot
    Q96QI5
    Related
    ENSP00000416741.3, ENST00000454677.3
    Conserved Domains (1) summary
    pfam00685
    Location:91326
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    1911475..1921428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522608.2XP_011520910.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform X1

    See identical proteins and their annotated locations for XP_011520910.1

    Conserved Domains (1) summary
    pfam00685
    Location:26201
    Sulfotransfer_1; Sulfotransferase domain
  2. XM_011522609.2XP_011520911.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform X2

    See identical proteins and their annotated locations for XP_011520911.1

    Conserved Domains (1) summary
    pfam00685
    Location:11186
    Sulfotransfer_1; Sulfotransferase domain

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187609.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    41605..48545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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