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COPS7B COP9 signalosome subunit 7B [ Homo sapiens (human) ]

Gene ID: 64708, updated on 8-Jan-2023

Summary

Official Symbol
COPS7Bprovided by HGNC
Official Full Name
COP9 signalosome subunit 7Bprovided by HGNC
Primary source
HGNC:HGNC:16760
See related
Ensembl:ENSG00000144524 MIM:616010; AllianceGenome:HGNC:16760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSN7B; SGN7b
Summary
Involved in protein deneddylation. Located in nucleoplasm. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 9.9), lymph node (RPKM 6.4) and 25 other tissues See more
Orthologs
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Genomic context

See COPS7B in Genome Data Viewer
Location:
2q37.1
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (231781671..231809253)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (232266242..232293824)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (232646381..232673963)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 6D Neighboring gene Sharpr-MPRA regulatory region 13150 Neighboring gene RNA, U6 small nuclear 840, pseudogene Neighboring gene ribosomal protein L28 pseudogene 2 Neighboring gene guanidinoacetate N-methyltransferase pseudogene 1 Neighboring gene microRNA 1471

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12612, MGC111077

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in COP9 signalosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in protein deneddylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein neddylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of protein neddylation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of COP9 signalosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
COP9 signalosome complex subunit 7b
Names
COP9 constitutive photomorphogenic homolog subunit 7B
JAB1-containing signalosome subunit 7b
signalosome subunit 7b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282949.3NP_001269878.1  COP9 signalosome complex subunit 7b isoform c

    See identical proteins and their annotated locations for NP_001269878.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has distinct N- and C-termini and is shorter than isoform a.
    Source sequence(s)
    AA126041, AC073476, AK307486, BE504900, DA754035
    Consensus CDS
    CCDS63152.1
    UniProtKB/TrEMBL
    J3KQ34
    Related
    ENSP00000386438.1, ENST00000409295.5
    Conserved Domains (1) summary
    smart00088
    Location:54143
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
  2. NM_001282950.3NP_001269879.1  COP9 signalosome complex subunit 7b isoform a

    See identical proteins and their annotated locations for NP_001269879.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (a).
    Source sequence(s)
    AA126041, AC073476, BC091493, BE504900, HY051259
    Consensus CDS
    CCDS63153.1
    UniProtKB/Swiss-Prot
    Q9H9Q2
    Related
    ENSP00000362710.3, ENST00000373608.7
    Conserved Domains (2) summary
    smart00088
    Location:88177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166212
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
  3. NM_001282951.3NP_001269880.1  COP9 signalosome complex subunit 7b isoform d

    See identical proteins and their annotated locations for NP_001269880.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks two exons that result in the loss of an in-frame segment in the 5' coding region, and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AA126041, AC073476, BE504900, BI906506, DA754035
    Consensus CDS
    CCDS74668.1
    UniProtKB/TrEMBL
    A0A087X1P5
    Related
    ENSP00000484363.1, ENST00000611614.4
    Conserved Domains (2) summary
    smart00088
    Location:46122
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:111160
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
  4. NM_001282952.3NP_001269881.1  COP9 signalosome complex subunit 7b isoform e

    See identical proteins and their annotated locations for NP_001269881.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks a portion of the 5' coding region, initiates translation at a downstream in-frame start codon, and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AA126041, AC073476, AK024273, BE504900
    Consensus CDS
    CCDS63154.1
    UniProtKB/Swiss-Prot
    Q9H9Q2
    UniProtKB/TrEMBL
    A0A024R478
    Related
    ENSP00000484579.1, ENST00000620578.4
    Conserved Domains (2) summary
    smart00088
    Location:270
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:59108
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
  5. NM_001308381.2NP_001295310.1  COP9 signalosome complex subunit 7b isoform f

    See identical proteins and their annotated locations for NP_001295310.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice acceptor site in the central coding region, compared to variant 1. The encoded isoform (f) has the same N- and C-termini, but is longer than isoform a.
    Source sequence(s)
    AA126041, AC073476, AK126326, BE504900, BX333333, HY051259
    Consensus CDS
    CCDS77539.1
    UniProtKB/TrEMBL
    J3KQ41, Q6ZTQ7
    Related
    ENSP00000386880.1, ENST00000410017.5
    Conserved Domains (2) summary
    smart00088
    Location:88177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166214
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
  6. NM_001369483.1NP_001356412.1  COP9 signalosome complex subunit 7b isoform b

    Status: VALIDATED

    Source sequence(s)
    AC073476
    Consensus CDS
    CCDS2488.1
    UniProtKB/Swiss-Prot
    Q9H7V6
    UniProtKB/TrEMBL
    A0A024R471
    Related
    ENSP00000386567.1, ENST00000410024.5
    Conserved Domains (2) summary
    smart00088
    Location:88177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
  7. NM_022730.4NP_073567.1  COP9 signalosome complex subunit 7b isoform b

    See identical proteins and their annotated locations for NP_073567.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AA126041, AC073476, AK022674, BE504900, HY051259
    Consensus CDS
    CCDS2488.1
    UniProtKB/Swiss-Prot
    Q9H7V6, Q9H9Q2
    UniProtKB/TrEMBL
    A0A024R471
    Related
    ENSP00000272995.5, ENST00000350033.8
    Conserved Domains (2) summary
    smart00088
    Location:88177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    231781671..231809253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712693.3XP_006712756.1  COP9 signalosome complex subunit 7b isoform X1

    See identical proteins and their annotated locations for XP_006712756.1

    UniProtKB/TrEMBL
    J3KQ41
    Conserved Domains (2) summary
    smart00088
    Location:88177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166214
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
  2. XM_047445433.1XP_047301389.1  COP9 signalosome complex subunit 7b isoform X2

  3. XM_047445434.1XP_047301390.1  COP9 signalosome complex subunit 7b isoform X3

    UniProtKB/TrEMBL
    Q6ZTQ7
  4. XM_011511638.3XP_011509940.1  COP9 signalosome complex subunit 7b isoform X3

    See identical proteins and their annotated locations for XP_011509940.1

    UniProtKB/TrEMBL
    Q6ZTQ7
    Conserved Domains (1) summary
    smart00753
    Location:270
    PAM; PCI/PINT associated module

RNA

  1. XR_001738900.3 RNA Sequence

  2. XR_007080108.1 RNA Sequence

    Related
    ENST00000413197.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    232266242..232293824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)