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Suv39h2 suppressor of variegation 3-9 2 [ Mus musculus (house mouse) ]

Gene ID: 64707, updated on 5-Jan-2023

Summary

Official Symbol
Suv39h2provided by MGI
Official Full Name
suppressor of variegation 3-9 2provided by MGI
Primary source
MGI:MGI:1890396
See related
Ensembl:ENSMUSG00000026646 AllianceGenome:MGI:1890396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KMT1B; D2Ertd544e; 4930507K23Rik; D030054H19Rik
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and histone-lysine N-methyltransferase activity. Involved in histone H3-K9 methylation; negative regulation of circadian rhythm; and negative regulation of transcription, DNA-templated. Acts upstream of or within histone H3-K9 methylation and male meiotic nuclear division. Located in heterochromatin and nucleus. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and limb. Orthologous to human SUV39H2 (SUV39H2 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 5.6), placenta adult (RPKM 3.1) and 21 other tissues See more
Orthologs
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Genomic context

See Suv39h2 in Genome Data Viewer
Location:
2 A1; 2 1.95 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (3456852..3476085, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (3455815..3474986, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39750 Neighboring gene meiosis expressed gene 1 Neighboring gene DNA cross-link repair 1C Neighboring gene predicted gene, 54099 Neighboring gene heat shock protein 14 Neighboring gene cerebral dopamine neurotrophic factor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables S-adenosyl-L-methionine binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3K9 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone H3K9 methyltransferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables histone H3K9 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H3K9 trimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone lysine N-methyltransferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone-lysine N-methyltransferase SUV39H2
Names
H3-K9-HMTase 2
Suv39h histone methyltransferase
histone H3-K9 methyltransferase 2
su(var)3-9 homolog 2
suppressor of variegation 3-9 homolog 2
NP_073561.2
XP_036018338.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022724.4NP_073561.2  histone-lysine N-methyltransferase SUV39H2

    See identical proteins and their annotated locations for NP_073561.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AK083457, AL732620, CX227854
    Consensus CDS
    CCDS15652.1
    UniProtKB/Swiss-Prot
    Q9EQQ0
    UniProtKB/TrEMBL
    A0A0R4J074
    Related
    ENSMUSP00000027956.3, ENSMUST00000027956.9
    Conserved Domains (3) summary
    smart00317
    Location:317446
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam00385
    Location:119164
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
    pfam05033
    Location:221309
    Pre-SET; Pre-SET motif

RNA

  1. NR_027509.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and therefore is not thought to encode a protein.
    Source sequence(s)
    AK083457, AL732620, BY752501, CX227854

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    3456852..3476085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162445.1XP_036018338.1  histone-lysine N-methyltransferase SUV39H2 isoform X1

    Conserved Domains (1) summary
    cd10532
    Location:15257
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins