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FAM227A family with sequence similarity 227 member A [ Homo sapiens (human) ]

Gene ID: 646851, updated on 1-Jun-2020

Summary

Official Symbol
FAM227Aprovided by HGNC
Official Full Name
family with sequence similarity 227 member Aprovided by HGNC
Primary source
HGNC:HGNC:44197
See related
Ensembl:ENSG00000184949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 1.8), thyroid (RPKM 0.5) and 11 other tissues See more
Orthologs

Genomic context

See FAM227A in Genome Data Viewer
Location:
22q13.1
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (38578118..38656629, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38974125..39052634, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373031 Neighboring gene ribosomal protein S29 pseudogene 31 Neighboring gene chibby family member 1, beta catenin antagonist Neighboring gene translocase of outer mitochondrial membrane 22 Neighboring gene Josephin domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • FLJ37761

General protein information

Preferred Names
protein FAM227A
Names
Protein FAM227A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013647.2NP_001013669.1  protein FAM227A isoform 1

    See identical proteins and their annotated locations for NP_001013669.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK301819, AL022320, DA378202, DB053353, DV080205
    UniProtKB/Swiss-Prot
    F5H4B4
    Related
    ENSP00000445093.1, ENST00000535113.5
    Conserved Domains (1) summary
    pfam14922
    Location:135296
    FWWh; Protein of unknown function
  2. NM_001291030.2NP_001277959.1  protein FAM227A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK301819, AL022320, DA378202, DV080205
    UniProtKB/Swiss-Prot
    F5H4B4
    Conserved Domains (1) summary
    pfam14922
    Location:42203
    FWWh; Protein of unknown function

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    38578118..38656629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530309.2XP_011528611.1  protein FAM227A isoform X3

    Related
    ENSP00000348086.7, ENST00000355830.11
    Conserved Domains (1) summary
    pfam14922
    Location:135296
    FWWh; Protein of unknown function
  2. XM_011530311.1XP_011528613.1  protein FAM227A isoform X5

    Conserved Domains (1) summary
    pfam14922
    Location:94255
    FWWh; Protein of unknown function
  3. XM_011530314.1XP_011528616.1  protein FAM227A isoform X9

    Conserved Domains (1) summary
    pfam14922
    Location:1139
    FWWh; Protein of unknown function
  4. XM_011530310.1XP_011528612.1  protein FAM227A isoform X4

    Conserved Domains (1) summary
    pfam14922
    Location:135261
    FWWh; Protein of unknown function
  5. XM_006724292.2XP_006724355.2  protein FAM227A isoform X2

    Conserved Domains (1) summary
    pfam14922
    Location:135296
    FWWh; Protein of unknown function
  6. XM_006724291.2XP_006724354.2  protein FAM227A isoform X1

    See identical proteins and their annotated locations for XP_006724354.2

    Conserved Domains (1) summary
    pfam14922
    Location:135296
    FWWh; Protein of unknown function
  7. XM_006724295.2XP_006724358.2  protein FAM227A isoform X7

    Conserved Domains (1) summary
    pfam14922
    Location:42203
    FWWh; Protein of unknown function
  8. XM_006724294.2XP_006724357.2  protein FAM227A isoform X6

    See identical proteins and their annotated locations for XP_006724357.2

    Conserved Domains (1) summary
    pfam14922
    Location:42203
    FWWh; Protein of unknown function
  9. XM_011530308.3XP_011528610.1  protein FAM227A isoform X1

    See identical proteins and their annotated locations for XP_011528610.1

    Conserved Domains (1) summary
    pfam14922
    Location:135296
    FWWh; Protein of unknown function
  10. XM_011530313.2XP_011528615.1  protein FAM227A isoform X6

    See identical proteins and their annotated locations for XP_011528615.1

    Conserved Domains (1) summary
    pfam14922
    Location:42203
    FWWh; Protein of unknown function
  11. XM_011530312.2XP_011528614.1  protein FAM227A isoform X6

    See identical proteins and their annotated locations for XP_011528614.1

    Conserved Domains (1) summary
    pfam14922
    Location:42203
    FWWh; Protein of unknown function
  12. XM_006724293.2XP_006724356.1  protein FAM227A isoform X8

    Conserved Domains (1) summary
    pfam14922
    Location:135296
    FWWh; Protein of unknown function

RNA

  1. XR_937892.1 RNA Sequence

  2. XR_937893.1 RNA Sequence

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