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FAM227A family with sequence similarity 227 member A [ Homo sapiens (human) ]

Gene ID: 646851, updated on 26-Oct-2022

Summary

Official Symbol
FAM227Aprovided by HGNC
Official Full Name
family with sequence similarity 227 member Aprovided by HGNC
Primary source
HGNC:HGNC:44197
See related
Ensembl:ENSG00000184949 AllianceGenome:HGNC:44197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 1.8), thyroid (RPKM 0.5) and 11 other tissues See more
Orthologs
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Genomic context

See FAM227A in Genome Data Viewer
Location:
22q13.1
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (38578118..38656392, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (39042376..39126576, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38974123..39052397, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373031 Neighboring gene ribosomal protein S29 pseudogene 31 Neighboring gene chibby family member 1, beta catenin antagonist Neighboring gene uncharacterized LOC124905117

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37761

General protein information

Preferred Names
protein FAM227A
Names
Protein FAM227A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013647.2NP_001013669.1  protein FAM227A isoform 1

    See identical proteins and their annotated locations for NP_001013669.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK301819, AL022320, DA378202, DB053353, DV080205
    Consensus CDS
    CCDS93164.1
    UniProtKB/Swiss-Prot
    F5H4B4, Q5TG08
    Related
    ENSP00000445093.1, ENST00000535113.7
    Conserved Domains (1) summary
    pfam14922
    Location:146296
    FWWh; Protein of unknown function
  2. NM_001291030.2NP_001277959.1  protein FAM227A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK301819, AL022320, DA378202, DV080205
    UniProtKB/Swiss-Prot
    F5H4B4
    Conserved Domains (1) summary
    pfam14922
    Location:42203
    FWWh; Protein of unknown function
  3. NM_001384270.1NP_001371199.1  protein FAM227A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL021707, AL022320, AL035495
    Conserved Domains (1) summary
    pfam14922
    Location:53203
    FWWh; Protein of unknown function
  4. NM_001384271.1NP_001371200.1  protein FAM227A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL021707, AL022320, AL035495
    Conserved Domains (1) summary
    pfam14922
    Location:1104
    FWWh; Protein of unknown function

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    38578118..38656392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441459.1XP_047297415.1  protein FAM227A isoform X9

  2. XM_011530311.2XP_011528613.1  protein FAM227A isoform X6

    Conserved Domains (1) summary
    pfam14922
    Location:94255
    FWWh; Protein of unknown function
  3. XM_047441456.1XP_047297412.1  protein FAM227A isoform X5

  4. XM_011530310.2XP_011528612.1  protein FAM227A isoform X4

    Conserved Domains (1) summary
    pfam14922
    Location:135261
    FWWh; Protein of unknown function
  5. XM_006724292.3XP_006724355.2  protein FAM227A isoform X2

    Conserved Domains (1) summary
    pfam14922
    Location:135296
    FWWh; Protein of unknown function
  6. XM_011530309.3XP_011528611.1  protein FAM227A isoform X3

    Related
    ENSP00000348086.7, ENST00000355830.11
    Conserved Domains (1) summary
    pfam14922
    Location:135296
    FWWh; Protein of unknown function
  7. XM_006724291.3XP_006724354.2  protein FAM227A isoform X1

    See identical proteins and their annotated locations for XP_006724354.2

    Conserved Domains (1) summary
    pfam14922
    Location:135296
    FWWh; Protein of unknown function
  8. XM_011530308.4XP_011528610.1  protein FAM227A isoform X1

    See identical proteins and their annotated locations for XP_011528610.1

    Conserved Domains (1) summary
    pfam14922
    Location:135296
    FWWh; Protein of unknown function
  9. XM_011530313.3XP_011528615.1  protein FAM227A isoform X7

    See identical proteins and their annotated locations for XP_011528615.1

    Conserved Domains (1) summary
    pfam14922
    Location:42203
    FWWh; Protein of unknown function
  10. XM_011530312.3XP_011528614.1  protein FAM227A isoform X7

    See identical proteins and their annotated locations for XP_011528614.1

    Conserved Domains (1) summary
    pfam14922
    Location:42203
    FWWh; Protein of unknown function
  11. XM_047441458.1XP_047297414.1  protein FAM227A isoform X8

  12. XM_047441457.1XP_047297413.1  protein FAM227A isoform X7

RNA

  1. XR_937892.2 RNA Sequence

    Related
    ENST00000544346.5
  2. XR_937893.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    39042376..39126576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)