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Nmi N-myc (and STAT) interactor [ Mus musculus (house mouse) ]

Gene ID: 64685, updated on 26-Sep-2022

Summary

Official Symbol
Nmiprovided by MGI
Official Full Name
N-myc (and STAT) interactorprovided by MGI
Primary source
MGI:MGI:1928368
See related
Ensembl:ENSMUSG00000026946 AllianceGenome:MGI:1928368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable identical protein binding activity. Involved in positive regulation of defense response; response to virus; and toll-like receptor 4 signaling pathway. Acts upstream of or within negative regulation of innate immune response; negative regulation of type I interferon production; and positive regulation of protein K48-linked ubiquitination. Located in extracellular space. Is expressed in genitourinary system; limb; and retina. Orthologous to human NMI (N-myc and STAT interactor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 5.8), large intestine adult (RPKM 5.4) and 25 other tissues See more
Orthologs
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Genomic context

See Nmi in Genome Data Viewer
Location:
2; 2 C1.1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (51838510..51863505, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (51948498..51973489, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13495 Neighboring gene chaperonin containing Tcp1, subunit 8 (theta) pseudogene Neighboring gene tumor necrosis factor alpha induced protein 6 Neighboring gene replication timing regulatory factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage activation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of interferon-alpha production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of type I interferon production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in type II interferon-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
N-myc-interactor
Names
N-mcy (and STAT) interactor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001141948.1NP_001135420.1  N-myc-interactor

    See identical proteins and their annotated locations for NP_001135420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AA217628, AF019249, AL929026, BY013052, CJ093824
    Consensus CDS
    CCDS16031.1
    UniProtKB/Swiss-Prot
    O35309, Q99M49
    UniProtKB/TrEMBL
    Q3UJ82
    Related
    ENSMUSP00000108325.3, ENSMUST00000112705.9
    Conserved Domains (2) summary
    pfam07334
    Location:30105
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
    pfam07292
    Location:204292
    NID; Nmi/IFP 35 domain (NID)
  2. NM_001141949.1NP_001135421.1  N-myc-interactor

    See identical proteins and their annotated locations for NP_001135421.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest variant.
    Source sequence(s)
    AA217628, AF019249, AK146577, AL929026, BY013052
    Consensus CDS
    CCDS16031.1
    UniProtKB/Swiss-Prot
    O35309, Q99M49
    UniProtKB/TrEMBL
    Q3UJ82
    Related
    ENSMUSP00000120647.2, ENSMUST00000145481.8
    Conserved Domains (2) summary
    pfam07334
    Location:30105
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
    pfam07292
    Location:204292
    NID; Nmi/IFP 35 domain (NID)
  3. NM_019401.2NP_062274.1  N-myc-interactor

    See identical proteins and their annotated locations for NP_062274.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.
    Source sequence(s)
    AF019249, AL929026, BY013052
    Consensus CDS
    CCDS16031.1
    UniProtKB/Swiss-Prot
    O35309, Q99M49
    UniProtKB/TrEMBL
    Q3UJ82
    Related
    ENSMUSP00000028314.3, ENSMUST00000028314.9
    Conserved Domains (2) summary
    pfam07334
    Location:30105
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
    pfam07292
    Location:204292
    NID; Nmi/IFP 35 domain (NID)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    51838510..51863505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498218.5XP_006498281.1  N-myc-interactor isoform X1

    See identical proteins and their annotated locations for XP_006498281.1

    UniProtKB/Swiss-Prot
    O35309, Q99M49
    UniProtKB/TrEMBL
    Q3UJ82
    Conserved Domains (2) summary
    pfam07334
    Location:30105
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
    pfam07292
    Location:204292
    NID; Nmi/IFP 35 domain (NID)
  2. XM_006498219.5XP_006498282.1  N-myc-interactor isoform X2

    Conserved Domains (2) summary
    pfam07334
    Location:30105
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
    pfam07292
    Location:106193
    NID; Nmi/IFP 35 domain (NID)
  3. XM_030251933.2XP_030107793.1  N-myc-interactor isoform X2

    Conserved Domains (2) summary
    pfam07334
    Location:30105
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
    pfam07292
    Location:106193
    NID; Nmi/IFP 35 domain (NID)