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Crhr2 corticotropin releasing hormone receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64680, updated on 12-Jan-2022

Summary

Official Symbol
Crhr2provided by RGD
Official Full Name
corticotropin releasing hormone receptor 2provided by RGD
Primary source
RGD:70547
See related
Ensembl:ENSRNOG00000011145
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Crf2r; CRF-R 2; CRH-R 2
Summary
Enables corticotropin-releasing hormone receptor activity and peptide hormone binding activity. Involved in several processes, including negative regulation of secretion; regulation of gene expression; and regulation of intracellular signal transduction. Located in several cellular components, including axon; cell body fiber; and perikaryon. Used to study colitis; ischemia; and muscular atrophy. Biomarker of colitis; functional colonic disease; irritable bowel syndrome; and mental depression. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CRHR2 (corticotropin releasing hormone receptor 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Muscle (RPKM 8.2), Heart (RPKM 5.4) and 5 other tissues See more
Orthologs
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Genomic context

See Crhr2 in Genome Data Viewer
Location:
4q24
Exon count:
14
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (84222897..84265924, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (85286371..85329374, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550675 Neighboring gene glycyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC102550746 Neighboring gene indolethylamine N-methyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables corticotrophin-releasing factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables corticotrophin-releasing factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables corticotropin-releasing hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables corticotropin-releasing hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in catecholamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to corticotropin-releasing hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucocorticoid stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cerebellum development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in feeding behavior NAS
Non-traceable Author Statement
more info
PubMed 
involved_in gastric motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in hypothalamus development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in long-term synaptic potentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of calcium ion import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of defecation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of epinephrine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of feeding behavior IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of follicle-stimulating hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of luteinizing hormone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of norepinephrine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cAMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of serotonin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal muscle tissue growth IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell body fiber IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in varicosity IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
corticotropin-releasing factor receptor 2
Names
CRF-R-2
CRF-R2
CRF2
CRFR-2
CRH-R-2
CRH-R2
corticotrophin releasing hormone receptor 2
corticotropin-releasing factor receptor subtype 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022714.2NP_073205.2  corticotropin-releasing factor receptor 2 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000142
    Related
    ENSRNOP00000035712.2, ENSRNOT00000033672.4
    Conserved Domains (3) summary
    smart00008
    Location:36107
    HormR; Domain present in hormone receptors
    cd14964
    Location:115140
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:113376
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    84222897..84265924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236557.3XP_006236619.1  corticotropin-releasing factor receptor 2 isoform X2

    Conserved Domains (2) summary
    smart00008
    Location:56127
    HormR; Domain present in hormone receptors
    pfam00002
    Location:132374
    7tm_2; 7 transmembrane receptor (Secretin family)
  2. XM_006236556.3XP_006236618.1  corticotropin-releasing factor receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_006236618.1

    UniProtKB/TrEMBL
    D4A5C4
    Related
    ENSRNOP00000079784.1, ENSRNOT00000098668.1
    Conserved Domains (2) summary
    smart00008
    Location:56127
    HormR; Domain present in hormone receptors
    pfam00002
    Location:133375
    7tm_2; 7 transmembrane receptor (Secretin family)
  3. XM_006236558.3XP_006236620.1  corticotropin-releasing factor receptor 2 isoform X3

    Conserved Domains (2) summary
    smart00008
    Location:36107
    HormR; Domain present in hormone receptors
    pfam00002
    Location:112354
    7tm_2; 7 transmembrane receptor (Secretin family)
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