Crhr2 corticotropin releasing hormone receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crhr2provided by RGD
Official Full Name: corticotropin releasing hormone receptor 2provided by RGD
Primary source: RGD:70547
See related: Ensembl:ENSRNOG00000011145 AllianceGenome:RGD:70547
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Crf2r; CRF-R 2; CRH-R 2
Summary: Enables corticotropin-releasing hormone receptor activity and peptide hormone binding activity. Involved in several processes, including negative regulation of secretion; regulation of gene expression; and regulation of intracellular signal transduction. Located in several cellular components, including axon; cell body fiber; and perikaryon. Used to study colitis; ischemia; and muscular atrophy. Biomarker of colitis; functional colonic disease; irritable bowel syndrome; and mental depression. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CRHR2 (corticotropin releasing hormone receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 8.2), Heart (RPKM 5.4) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
108	current	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (84222897..84265924, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (85286371..85329374, complement)

Chromosome 4 - NC_051339.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Double Insult of Neonatal Cystitis Plus Adult Somatic Inflammation Results in Corticotropin Releasing Factor Type II Receptor-Dependent Bladder Hypersensitivity in Female Rats.
Title: The Double Insult of Neonatal Cystitis Plus Adult Somatic Inflammation Results in Corticotropin Releasing Factor Type II Receptor-Dependent Bladder Hypersensitivity in Female Rats.
Functional and Anatomical Characterization of Corticotropin-Releasing Factor Receptor Subtypes of the Rat Spinal Cord Involved in Somatic Pain Relief.
Title: Functional and Anatomical Characterization of Corticotropin-Releasing Factor Receptor Subtypes of the Rat Spinal Cord Involved in Somatic Pain Relief.
Norepinephrine and Glucocorticoids Modulate Chronic Unpredictable Stress-Induced Increase in the Type 2 CRF and Glucocorticoid Receptors in Brain Structures Related to the HPA Axis Activation.
Title: Norepinephrine and Glucocorticoids Modulate Chronic Unpredictable Stress-Induced Increase in the Type 2 CRF and Glucocorticoid Receptors in Brain Structures Related to the HPA Axis Activation.
Cross-talk between dopamine D1 and corticotropin releasing factor type 2 receptors leads to occlusion of their ERK1/2 signaling.
Title: Cross-talk between dopamine D1 and corticotropin releasing factor type 2 receptors leads to occlusion of their ERK1/2 signaling.
Results demonstrate that corticotropin-releasing factor excites the lateral vestibular nuclear (LVN) neurons by co-activation of both CRF receptors 1 and CRF receptors 2, suggesting that via the direct modulation on the LVN.
Title: Corticotropin-releasing factor depolarizes rat lateral vestibular nuclear neurons through activation of CRF receptors 1 and 2.
During the period of alcohol withdrawal, the level of CRFR2 mRNA in the ventral tegmental area of the brain on the seventh day of abstinence was significantly increased in comparison with the control group
Title: [Ethanol withdrawal leads to an increase in the CRFR2 mRNA level in the ventricular tegmental region of the rat brain].
Expression of OXTR became reduced following SPS in mPFC and amygdala, the latter exhibited higher therapeutic specificity to OXT. Expression of CRHR1 appeared more sensitive than CRHR2 to SPS, higher CRHR1 protein levels were found in mPFC and amygdala.
Title: Effects of oxytocin on prosocial behavior and the associated profiles of oxytocinergic and corticotropin-releasing hormone receptors in a rodent model of posttraumatic stress disorder.
Environmental enrichment (EE) and Colony Nesting (CN)increased prosocial engagement and the social saliency of male and female rats while the profile of hippocampal Crhr2 expression was affected only in EE males. Hippocampal Crh was associated with anxiety-like behavior in standard housing males - this did not extend to EE or CN groups, nor to females.
Title: Complex Environmental Rearing Enhances Social Salience and Affects Hippocampal Corticotropin Releasing Hormone Receptor Expression in a Sex-Specific Manner.
Significantly higher CRF1 and CRF2 receptor levels after sensitization were detected in the Hippocampus. Additionally, CRF2 receptor levels were augmented by sensitization in the PreFrontal Cortex, and treatment and time-induced increases were detected in the Dorsal Striatum.
Title: Increased expression of CRF and CRF-receptors in dorsal striatum, hippocampus, and prefrontal cortex after the development of nicotine sensitization in rats.
CRF2 signaling could modulate intestinal epithelial cell differentiation. These mechanisms could be relevant to the stress induced epithelial alterations found in inflammatory bowel diseases.
Title: Involvement of CRF2 signaling in enterocyte differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (95)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4Rat170 (e-PCR), detects polymorphism
- UniSTS:227730

CRHR2 (e-PCR)
- UniSTS:510380

BE120072 (e-PCR)
- UniSTS:247236

Homology

Homologs of the Crhr2 gene: The Crhr2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 328 organisms have orthologs with human gene Crhr2
Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables corticotrophin-releasing factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables corticotrophin-releasing factor receptor activity	ISO Inferred from Sequence Orthology more info
enables corticotropin-releasing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables corticotropin-releasing hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables peptide hormone binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in catecholamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in feeding behavior	NAS Non-traceable Author Statement more info	PubMed
involved_in gastric motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hypothalamus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epinephrine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of feeding behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of follicle-stimulating hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of luteinizing hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of norepinephrine secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cAMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cAMP-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of serotonin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress-activated MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle tissue growth	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon terminus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cell body fiber	IDA Inferred from Direct Assay more info	PubMed
NOT located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in varicosity	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: corticotropin-releasing factor receptor 2

Names: CRF-R-2; CRF-R2; CRF2; CRFR-2; CRH-R-2; CRH-R2; corticotrophin releasing hormone receptor 2; corticotropin-releasing factor receptor subtype 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022714.2 → NP_073205.2 corticotropin-releasing factor receptor 2 precursor

Status: PROVISIONAL

Source sequence(s)

JACYVU010000142

UniProtKB/Swiss-Prot

G3V948

Related

ENSRNOP00000035712.2, ENSRNOT00000033672.4

Conserved Domains (3) summary

smart00008
Location:36 → 107

HormR; Domain present in hormone receptors

cd14964
Location:115 → 140

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:113 → 376

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

NC_051339.1 Reference mRatBN7.2 Primary Assembly

Range

84222897..84265924 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236557.3 → XP_006236619.1 corticotropin-releasing factor receptor 2 isoform X2

Conserved Domains (2) summary

smart00008
Location:56 → 127

HormR; Domain present in hormone receptors

pfam00002
Location:132 → 374

7tm_2; 7 transmembrane receptor (Secretin family)
XM_006236556.3 → XP_006236618.1 corticotropin-releasing factor receptor 2 isoform X1

See identical proteins and their annotated locations for XP_006236618.1

UniProtKB/TrEMBL

A0A8I5ZNG6, D4A5C4

Related

ENSRNOP00000079784.1, ENSRNOT00000098668.1

Conserved Domains (2) summary

smart00008
Location:56 → 127

HormR; Domain present in hormone receptors

pfam00002
Location:133 → 375

7tm_2; 7 transmembrane receptor (Secretin family)
XM_006236558.3 → XP_006236620.1 corticotropin-releasing factor receptor 2 isoform X3

Conserved Domains (2) summary

smart00008
Location:36 → 107

HormR; Domain present in hormone receptors

pfam00002
Location:112 → 354

7tm_2; 7 transmembrane receptor (Secretin family)