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Tfrc transferrin receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 64678, updated on 22-May-2022

Summary

Official Symbol
Tfrcprovided by RGD
Official Full Name
transferrin receptorprovided by RGD
Primary source
RGD:70488
See related
Ensembl:ENSRNOG00000001766 AllianceGenome:RGD:70488
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Trfr
Summary
Enables Hsp70 protein binding activity; chaperone binding activity; and transferrin receptor activity. Involved in several processes, including response to copper ion; response to manganese ion; and response to retinoic acid. Located in several cellular components, including cell surface; extracellular exosome; and recycling endosome membrane. Biomarker of duodenal ulcer; hepatocellular carcinoma; muscular atrophy; non-alcoholic fatty liver disease; and nutrition disease. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to human TFRC (transferrin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 1367.6), Muscle (RPKM 1319.0) and 8 other tissues See more
Orthologs
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Genomic context

See Tfrc in Genome Data Viewer
Location:
11q22
Exon count:
21
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (68163413..68185257, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (71397423..71419263, complement)

Chromosome 11 - NC_051346.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095667 Neighboring gene tyrosine kinase, non-receptor, 2 Neighboring gene U2 spliceosomal RNA Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 12 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transferrin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferrin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transferrin receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in acute-phase response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in iron ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of isotype switching ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of isotype switching ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to copper ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to inorganic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to iron ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to manganese ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in transferrin transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of HFE-transferrin receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transferrin receptor protein 1
Names
TR
tfR
tfR1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022712.1NP_073203.1  transferrin receptor protein 1

    See identical proteins and their annotated locations for NP_073203.1

    Status: VALIDATED

    Source sequence(s)
    AI029320, BP500872, CA509549, CB700894, CB762571, CB809947, CO398424, CV111368, CV117299, CV117527, FM033330, FM123390
    UniProtKB/TrEMBL
    G3V679
    Related
    ENSRNOP00000002407.3, ENSRNOT00000002407.6
    Conserved Domains (3) summary
    cd02128
    Location:201378
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:386611
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:638751
    TFR_dimer; Transferrin receptor-like dimerization domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051346.1 Reference mRatBN7.2 Primary Assembly

    Range
    68163413..68185257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248462.4XP_006248524.1  transferrin receptor protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006248524.1

    UniProtKB/TrEMBL
    G3V679
    Conserved Domains (3) summary
    cd02128
    Location:201378
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:386611
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:638751
    TFR_dimer; Transferrin receptor-like dimerization domain
  2. XM_006248463.4XP_006248525.1  transferrin receptor protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006248525.1

    UniProtKB/TrEMBL
    G3V679
    Conserved Domains (3) summary
    cd02128
    Location:201378
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:386611
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:638751
    TFR_dimer; Transferrin receptor-like dimerization domain
  3. XM_039088614.1XP_038944542.1  transferrin receptor protein 1 isoform X1

    Conserved Domains (3) summary
    cd02128
    Location:201378
    PA_TfR; Protease-associated domain containing proteins like transferrin receptor (TfR). This group contains various PA domain-containing proteins similar to human TfR1 and TfR2. TfR1 and TfR2 are type II membrane proteins, belonging to the peptidase M28 family. ...
    cd09848
    Location:386611
    M28_TfR; M28 Zn-peptidase Transferrin Receptor family
    pfam04253
    Location:638751
    TFR_dimer; Transferrin receptor-like dimerization domain