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Flot1 flotillin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64665, updated on 22-Apr-2017
Official Symbol
Flot1provided by RGD
Official Full Name
flotillin 1provided by RGD
Primary source
RGD:70991
See related
Ensembl:ENSRNOG00000000826 Vega:OTTRNOG00000001526
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rareg
Summary
colocalized with activated GPI-linked cell adhesion molecules at the plasma membrane where transmembrane signaling may occur [RGD, Feb 2006]
Orthologs
Location:
20p12
Exon count:
13
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3427890..3438418, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (5524708..5535232, complement)

Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene mediator of DNA damage checkpoint 1 Neighboring gene tubulin, beta 5 class I Neighboring gene immediate early response 3 Neighboring gene uncharacterized LOC102553445

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystem
    Insulin Signaling
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
axonogenesis IEA
Inferred from Electronic Annotation
more info
 
axonogenesis ISO
Inferred from Sequence Orthology
more info
 
cellular response to exogenous dsRNA IEA
Inferred from Electronic Annotation
more info
 
cellular response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
 
dsRNA transport IEA
Inferred from Electronic Annotation
more info
 
dsRNA transport ISO
Inferred from Sequence Orthology
more info
 
establishment of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
establishment of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix disassembly IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
membrane raft assembly ISO
Inferred from Sequence Orthology
more info
 
plasma membrane raft assembly IEA
Inferred from Electronic Annotation
more info
 
plasma membrane raft assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell adhesion molecule production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell adhesion molecule production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell junction assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell junction assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell-cell adhesion mediated by cadherin IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interferon-beta production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of myoblast fusion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myoblast fusion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synaptic transmission, dopaminergic ISO
Inferred from Sequence Orthology
more info
 
positive regulation of toll-like receptor 3 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein kinase C signaling IEA
Inferred from Electronic Annotation
more info
 
protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
 
protein localization to membrane raft IEA
Inferred from Electronic Annotation
more info
 
protein localization to membrane raft ISO
Inferred from Sequence Orthology
more info
 
protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein stabilization IEA
Inferred from Electronic Annotation
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
regulation of receptor internalization IEA
Inferred from Electronic Annotation
more info
 
regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
NOT regulation of toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
COP9 signalosome IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with COP9 signalosome ISO
Inferred from Sequence Orthology
more info
 
NOT apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
caveola ISO
Inferred from Sequence Orthology
more info
 
cell-cell adherens junction IEA
Inferred from Electronic Annotation
more info
 
cell-cell adherens junction ISO
Inferred from Sequence Orthology
more info
 
cell-cell contact zone IEA
Inferred from Electronic Annotation
more info
 
cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
centriolar satellite IEA
Inferred from Electronic Annotation
more info
 
centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cortical actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
flotillin complex IDA
Inferred from Direct Assay
more info
PubMed 
flotillin complex ISO
Inferred from Sequence Orthology
more info
 
focal adhesion IEA
Inferred from Electronic Annotation
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
microtubule organizing center ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
uropod IEA
Inferred from Electronic Annotation
more info
 
uropod ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
flotillin-1
Names
REG-2
reggie-2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022701.2NP_073192.2  flotillin-1

    See identical proteins and their annotated locations for NP_073192.2

    Status: VALIDATED

    Source sequence(s)
    CB324456, CB326388, CK359020, DY569467
    UniProtKB/Swiss-Prot
    Q9Z1E1
    Related
    ENSRNOP00000071275.1, ENSRNOT00000090039.1
    Conserved Domains (4) summary
    COG2268
    Location:4424
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:30175
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam15975
    Location:310395
    Flot; Flotillin
    cl19107
    Location:241344
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

    Range
    3427890..3438418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256024.3XP_006256086.1  flotillin-1 isoform X1

    See identical proteins and their annotated locations for XP_006256086.1

    UniProtKB/Swiss-Prot
    Q9Z1E1
    Related
    ENSRNOP00000001098.2, OTTRNOP00000001362, ENSRNOT00000001098.4, OTTRNOT00000002383
    Conserved Domains (4) summary
    COG2268
    Location:4424
    YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
    cd03399
    Location:30175
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam15975
    Location:310395
    Flot; Flotillin
    cl19107
    Location:241344
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

Alternate Rn_Celera

Genomic

  1. AC_000088.1 Alternate Rn_Celera

    Range
    343778..353887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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