SBK2 SH3 domain binding kinase family member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SBK2provided by HGNC
Official Full Name: SH3 domain binding kinase family member 2provided by HGNC
Primary source: HGNC:HGNC:34416
See related: Ensembl:ENSG00000187550
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SGK069
Summary: Predicted to enable MAP kinase kinase activity. Predicted to be involved in MAPK cascade and protein phosphorylation. [provided by Alliance of Genome Resources, Nov 2021]
Expression: Restricted expression toward heart (RPKM 14.0) See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.42

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109.20211119	current	GRCh38.p13 (GCF_000001405.39)	19	NC_000019.10 (55528611..55537174, complement)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (56039978..56048500, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Better known as SgK069. Contains predicted active kinase domain, classified into the NKF1 metazoan-specific family of kinases. "Bsk146" is an obsolete term for it's paralog, SBK1.
Title: The protein kinase complement of the human genome.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Homology

Homologs of the SBK2 gene: The SBK2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 189 organisms have orthologs with human gene SBK2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase SBK2

Names: SH3-binding domain kinase family, member 2; Sugen kinase 69

NP_001357025.1

EC 2.7.11.1

XP_011525529.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370096.2 → NP_001357025.1 serine/threonine-protein kinase SBK2

Status: VALIDATED

Source sequence(s)

AC008735

Consensus CDS

CCDS42631.1

Related

ENSP00000389015.2, ENST00000413299.6

Conserved Domains (1) summary

cl21453
Location:68 → 329

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p13 Primary Assembly

Range

55528611..55537174 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011527227.2 → XP_011525529.1 serine/threonine-protein kinase SBK2 isoform X2

Conserved Domains (1) summary

cl21453
Location:68 → 153

PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001101401.2: Suppressed sequence

Description

NM_001101401.2: This RefSeq was removed because currently there is not sufficient data to support this transcript.