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SBK2 SH3 domain binding kinase family member 2 [ Homo sapiens (human) ]

Gene ID: 646643, updated on 9-Jun-2025
Official Symbol
SBK2provided by HGNC
Official Full Name
SH3 domain binding kinase family member 2provided by HGNC
Primary source
HGNC:HGNC:34416
See related
Ensembl:ENSG00000187550 MIM:620414; AllianceGenome:HGNC:34416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGK069
Summary
Predicted to enable MAP kinase kinase activity. Predicted to be involved in MAPK cascade. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Restricted expression toward heart (RPKM 14.0) See more
Orthologs
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See SBK2 in Genome Data Viewer
Location:
19q13.42
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55528611..55537133, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58624919..58633076, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56039978..56048500, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11038 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15097 Neighboring gene N-acetyltransferase 14 (putative) Neighboring gene scavenger receptor cysteine rich family member with 5 domains Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11040 Neighboring gene Sharpr-MPRA regulatory region 5021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56028273-56028774 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:56032833-56032983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56037524-56038398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56042573-56043073 Neighboring gene Sharpr-MPRA regulatory region 3421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56056311-56057147 Neighboring gene Sharpr-MPRA regulatory region 14522 Neighboring gene SH3 domain binding kinase family member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56064283-56064783 Neighboring gene zinc finger protein 579

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
serine/threonine-protein kinase SBK2
Names
SH3-binding domain kinase family, member 2
Sugen kinase 69
NP_001357025.1
XP_011525529.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370096.2NP_001357025.1  serine/threonine-protein kinase SBK2

    Status: VALIDATED

    Source sequence(s)
    AC008735
    Consensus CDS
    CCDS42631.1
    UniProtKB/Swiss-Prot
    P0C263
    Related
    ENSP00000389015.2, ENST00000413299.6
    Conserved Domains (1) summary
    cl21453
    Location:68329
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    55528611..55537133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527227.3XP_011525529.1  serine/threonine-protein kinase SBK2 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:68153
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    58624919..58633076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001101401.2: Suppressed sequence

    Description
    NM_001101401.2: This RefSeq was removed because currently there is not sufficient data to support this transcript.