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SPANXC SPANX family member C [ Homo sapiens (human) ]

Gene ID: 64663, updated on 11-Jun-2021

Summary

Official Symbol
SPANXCprovided by HGNC
Official Full Name
SPANX family member Cprovided by HGNC
Primary source
HGNC:HGNC:14331
See related
Ensembl:ENSG00000198573 MIM:300330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTp11; CT11.3; SPANXE; SPANX-C; SPANX-E
Summary
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family, which is located in a gene cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a protein that localizes to the nucleus and is expressed in highly metastatic cell lines, making the protein a potential diagnostic and prognostic marker. The protein belongs to a family of cancer/testis antigens and represents a potential target for cancer immunotherapy. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 12.8) See more
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Genomic context

See SPANXC in Genome Data Viewer
Location:
Xq27.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (141241463..141242517, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X (PATCHES) NW_004070888.1 (337266..338320, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RPL36A pseudogene 52 Neighboring gene LDOC1 regulator of NFKB signaling Neighboring gene RBMX2 pseudogene 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
sperm protein associated with the nucleus on the X chromosome C
Names
Nuclear-associated protein SPAN-Xe
SPAN-Xc protein
Sperm protein associated with the nucleus on the X chromosome E
cancer-testis-associated protein CTp11
cancer/testis antigen 11.3
cancer/testis antigen family 11, member 3
cancer/testis-associated protein of 11 kD
nuclear-associated protein SPAN-Xc
sperm protein associated with the nucleus, X chromosome, family member C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022661.4NP_073152.2  sperm protein associated with the nucleus on the X chromosome C

    See identical proteins and their annotated locations for NP_073152.2

    Status: REVIEWED

    Source sequence(s)
    AC234777, BC103960
    Consensus CDS
    CCDS14673.1
    UniProtKB/Swiss-Prot
    Q9NY87
    Related
    ENSP00000351884.2, ENST00000358993.3
    Conserved Domains (1) summary
    pfam07458
    Location:281
    SPAN-X; Sperm protein associated with nucleus, mapped to X chromosome

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    141241463..141242517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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