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URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase [ Homo sapiens (human) ]

Gene ID: 646625, updated on 9-Jun-2025
Official Symbol
URADprovided by HGNC
Official Full Name
ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylaseprovided by HGNC
Primary source
HGNC:HGNC:17785
See related
Ensembl:ENSG00000183463 MIM:615804; AllianceGenome:HGNC:17785
Gene type
protein coding
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRHOXNB
Summary
Predicted to enable 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity. Predicted to be involved in amide catabolic process; nucleobase-containing small molecule metabolic process; and urate catabolic process. Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Biased expression in colon (RPKM 3.8), small intestine (RPKM 0.9) and 2 other tissues See more
Orthologs
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See URAD in Genome Data Viewer
Location:
13q12.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (27977717..27988693, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (27199102..27210083, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (28551854..28562830, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5205 Neighboring gene long intergenic non-protein coding RNA 543 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr13:28539919-28540610 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:28540611-28541302 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:28542687-28543378 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr13:28545455-28546102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:28546103-28546749 Neighboring gene caudal type homeobox 2 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr13:28552766-28553299 Neighboring gene uncharacterized LOC105370132 Neighboring gene RNA, 7SL, cytoplasmic 272, pseudogene Neighboring gene fms related receptor tyrosine kinase 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:28596542-28597075 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:28597076-28597608 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:28624211-28624978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:28625785-28626285 Neighboring gene katanin regulatory subunit B1 like 1 pseudogene 1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables carboxy-lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in allantoin metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in purine nucleobase metabolic process IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in urate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Names
OHCU decarboxylase
parahox cluster neighbor
NP_001099047.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105577.2NP_001099047.1  putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

    See identical proteins and their annotated locations for NP_001099047.1

    Status: INFERRED

    Source sequence(s)
    AL591024
    Consensus CDS
    CCDS45020.1
    UniProtKB/Swiss-Prot
    A6NGE7
    Related
    ENSP00000333490.4, ENST00000332715.6
    Conserved Domains (1) summary
    pfam09349
    Location:10163
    OHCU_decarbox; OHCU decarboxylase

RNA

  1. NR_197241.1 RNA Sequence

    Status: INFERRED

    Source sequence(s)
    AL591024
    Related
    ENST00000713555.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    27977717..27988693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    27199102..27210083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)