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URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase [ Homo sapiens (human) ]

Gene ID: 646625, updated on 7-Jul-2022

Summary

Official Symbol
URADprovided by HGNC
Official Full Name
ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylaseprovided by HGNC
Primary source
HGNC:HGNC:17785
See related
Ensembl:ENSG00000183463 MIM:615804; AllianceGenome:HGNC:17785
Gene type
protein coding
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRHOXNB
Summary
Predicted to enable carboxy-lyase activity. Predicted to be involved in purine-containing compound catabolic process. Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon (RPKM 3.8), small intestine (RPKM 0.9) and 2 other tissues See more
Orthologs
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Genomic context

See URAD in Genome Data Viewer
Location:
13q12.2
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (27977717..27988693, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (27199102..27210083, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (28551854..28562830, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 543 Neighboring gene caudal type homeobox 2 Neighboring gene uncharacterized LOC105370132 Neighboring gene RNA, 7SL, cytoplasmic 272, pseudogene Neighboring gene fms related receptor tyrosine kinase 3 Neighboring gene katanin regulatory subunit B1 like 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables carboxy-lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in allantoin metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in purine nucleobase metabolic process IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in urate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Names
OHCU decarboxylase
parahox cluster neighbor
NP_001099047.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105577.2NP_001099047.1  putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

    See identical proteins and their annotated locations for NP_001099047.1

    Status: INFERRED

    Source sequence(s)
    AL591024
    Consensus CDS
    CCDS45020.1
    UniProtKB/Swiss-Prot
    A6NGE7
    Related
    ENSP00000333490.4, ENST00000332715.6
    Conserved Domains (1) summary
    pfam09349
    Location:10163
    OHCU_decarbox; OHCU decarboxylase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    27977717..27988693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    27199102..27210083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)