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Nisch nischarin [ Mus musculus (house mouse) ]

Gene ID: 64652, updated on 31-Jan-2023

Summary

Official Symbol
Nischprovided by MGI
Official Full Name
nischarinprovided by MGI
Primary source
MGI:MGI:1928323
See related
Ensembl:ENSMUSG00000021910 AllianceGenome:MGI:1928323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
I-1; edsn; 1200007D05Rik; 3202002H23Rik
Summary
Enables integrin binding activity. Acts upstream of or within Rac protein signal transduction; actin cytoskeleton organization; and negative regulation of cell migration. Located in cytosol. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Used to study otitis media. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human NISCH (nischarin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 82.3), adrenal adult (RPKM 79.3) and 28 other tissues See more
Orthologs
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Genomic context

See Nisch in Genome Data Viewer
Location:
14; 14 B
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30892885..30928783, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31170928..31206826, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase domain containing 2 Neighboring gene stabilin 1 Neighboring gene predicted gene, 52148 Neighboring gene troponin C, cardiac/slow skeletal Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nischarin
Names
I1R
IR1
imidazoline receptor 1
imidazoline receptor I-1-like protein
imidazoline-1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347583.1NP_001334512.1  nischarin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple exons and includes an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154446, AK004628, AK160990, BY602009, CJ106892
    Consensus CDS
    CCDS84107.1
    UniProtKB/TrEMBL
    Q8CF63
    Related
    ENSMUSP00000132413.2, ENSMUST00000172142.8
  2. NM_022656.2NP_073147.2  nischarin isoform 1

    See identical proteins and their annotated locations for NP_073147.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC154446, AK122412, BC089329, BP761152, CJ106892
    Consensus CDS
    CCDS36853.1
    UniProtKB/Swiss-Prot
    Q80TM9, Q9WUM6
    Related
    ENSMUSP00000022469.7, ENSMUST00000022469.13
    Conserved Domains (5) summary
    cd06875
    Location:15130
    PX_IRAS; The phosphoinositide binding Phox Homology domain of the Imidazoline Receptor Antisera-Selected
    cd00116
    Location:271417
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:291313
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:312352
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:291346
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30892885..30928783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158779.1XP_036014672.1  nischarin isoform X1

  2. XM_017316116.1XP_017171605.1  nischarin isoform X1

  3. XM_017316115.3XP_017171604.1  nischarin isoform X1