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FABP12 fatty acid binding protein 12 [ Homo sapiens (human) ]

Gene ID: 646486, updated on 5-Aug-2022

Summary

Official Symbol
FABP12provided by HGNC
Official Full Name
fatty acid binding protein 12provided by HGNC
Primary source
HGNC:HGNC:34524
See related
Ensembl:ENSG00000197416 MIM:618923; AllianceGenome:HGNC:34524
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable lipid binding activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See FABP12 in Genome Data Viewer
Location:
8q21.13
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (81524981..81590139, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (81956575..81965536, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (82437216..82446177, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927118 Neighboring gene fatty acid binding protein 4 Neighboring gene ferritin heavy chain 1 pseudogene 11 Neighboring gene inositol monophosphatase 1 pseudogene 1 Neighboring gene NIPA2 pseudogene 4 Neighboring gene ribosomal protein S26 pseudogene 34

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in fatty acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
fatty acid-binding protein 12
Names
Probable fatty acid-binding protein ENSP00000353650
fatty acid binding protein ORF
intracellular fatty acid-binding protein FABP12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105281.5NP_001098751.1  fatty acid-binding protein 12

    See identical proteins and their annotated locations for NP_001098751.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AC023644
    Consensus CDS
    CCDS47882.1
    UniProtKB/Swiss-Prot
    A6NFH5, B7SUN0
    Related
    ENSP00000353650.4, ENST00000360464.6
    Conserved Domains (1) summary
    pfam00061
    Location:6131
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RNA

  1. NR_144370.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC023644, BC146973, BE463892
    Related
    ENST00000519696.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    81524981..81590139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517577.3XP_011515879.1  fatty acid-binding protein 12 isoform X1

    See identical proteins and their annotated locations for XP_011515879.1

    UniProtKB/Swiss-Prot
    A6NFH5, B7SUN0
    Related
    ENSP00000510293.1, ENST00000692030.1
    Conserved Domains (1) summary
    pfam00061
    Location:6131
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
  2. XM_006716465.4XP_006716528.1  fatty acid-binding protein 12 isoform X1

    See identical proteins and their annotated locations for XP_006716528.1

    UniProtKB/Swiss-Prot
    A6NFH5, B7SUN0
    Conserved Domains (1) summary
    pfam00061
    Location:6131
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    81956575..81965536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)