U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MFSD14A major facilitator superfamily domain containing 14A [ Homo sapiens (human) ]

Gene ID: 64645, updated on 22-Sep-2022

Summary

Official Symbol
MFSD14Aprovided by HGNC
Official Full Name
major facilitator superfamily domain containing 14Aprovided by HGNC
Primary source
HGNC:HGNC:23363
See related
Ensembl:ENSG00000156875 AllianceGenome:HGNC:23363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIAT1
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within acrosome assembly; sperm mitochondrion organization; and spermatid nucleus differentiation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 31.6), testis (RPKM 26.1) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MFSD14A in Genome Data Viewer
Location:
1p21.2
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (100038095..100083377)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (99886211..99931496)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (100503651..100548933)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904230 Neighboring gene solute carrier family 35 member A3 Neighboring gene RNA, U6 small nuclear 750, pseudogene Neighboring gene RNA, U6 small nuclear 1318, pseudogene Neighboring gene SAS-6 centriolar assembly protein Neighboring gene Sharpr-MPRA regulatory region 13340 Neighboring gene tRNA methyltransferase 13 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564L0864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acrosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in sperm mitochondrion organization IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatid nucleus differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hippocampus abundant transcript 1 protein
Names
hippocampus abundant gene transcript 1
putative tetracycline transporter-like protein
tetracycline transporter-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033055.3NP_149044.2  hippocampus abundant transcript 1 protein

    See identical proteins and their annotated locations for NP_149044.2

    Status: VALIDATED

    Source sequence(s)
    AC093019, AF427492, AK075208, BC033696
    Consensus CDS
    CCDS763.1
    UniProtKB/Swiss-Prot
    Q96MC6, Q9NT25
    Related
    ENSP00000359171.3, ENST00000370152.8
    Conserved Domains (1) summary
    cd17387
    Location:37449
    MFS_MFSD14; Major facilitator superfamily domain-containing 14A and 14B

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    100038095..100083377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541957.2XP_011540259.1  hippocampus abundant transcript 1 protein isoform X2

    Conserved Domains (2) summary
    cd06174
    Location:40359
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:42348
    MFS_1; Major Facilitator Superfamily
  2. XM_047427999.1XP_047283955.1  hippocampus abundant transcript 1 protein isoform X3

  3. XM_047427996.1XP_047283952.1  hippocampus abundant transcript 1 protein isoform X1

  4. XM_017002084.2XP_016857573.1  hippocampus abundant transcript 1 protein isoform X1

    Conserved Domains (1) summary
    cd17387
    Location:15427
    MFS_MFSD14; Major facilitator superfamily domain-containing 14A and 14B

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    99886211..99931496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)