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EBF2 EBF transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 64641, updated on 7-Jun-2020

Summary

Official Symbol
EBF2provided by HGNC
Official Full Name
EBF transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:19090
See related
Ensembl:ENSG00000221818 MIM:609934
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COE2; OE-3; EBF-2; O/E-3
Summary
The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix transcription factors that have a well conserved DNA binding domain. The COE family proteins play an important role in variety of developmental processes. Studies in mouse suggest that this gene may be involved in the differentiation of osteoblasts. [provided by RefSeq, Oct 2011]
Expression
Biased expression in fat (RPKM 8.6), heart (RPKM 4.4) and 7 other tissues See more
Orthologs

Genomic context

See EBF2 in Genome Data Viewer
Location:
8p21.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (25841725..26045413, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (25699246..25902640, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986933 Neighboring gene uncharacterized LOC105379333 Neighboring gene uncharacterized LOC105379332 Neighboring gene uncharacterized LOC102723395 Neighboring gene uncharacterized LOC105379335 Neighboring gene uncharacterized LOC105379336 Neighboring gene RNA, 5S ribosomal pseudogene 258

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11500

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adipose tissue development IEA
Inferred from Electronic Annotation
more info
 
brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell fate determination IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chromatin binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription factor COE2
Names
Collier, Olf and EBF 2
Collier, Olf and EBF transcription factor 2
OLF-1/EBF-LIKE 3
early B cell factor 2
metencephalon-mesencephalnon-olfactory transcription factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030344.1 RefSeqGene

    Range
    4712..208400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022659.4NP_073150.2  transcription factor COE2

    See identical proteins and their annotated locations for NP_073150.2

    Status: REVIEWED

    Source sequence(s)
    AC023566, AC090103, AI457889, AK021562, AK093878, AK304372, BC137106, BQ878633, BY798905
    Consensus CDS
    CCDS43726.1
    UniProtKB/Swiss-Prot
    Q9HAK2
    UniProtKB/TrEMBL
    B2RNT0, B7Z934
    Related
    ENSP00000430241.1, ENST00000520164.6
    Conserved Domains (3) summary
    cd01175
    Location:253337
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:20246
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:338381
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    25841725..26045413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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