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SHC1 SHC adaptor protein 1 [ Homo sapiens (human) ]

Gene ID: 6464, updated on 24-Nov-2020

Summary

Official Symbol
SHC1provided by HGNC
Official Full Name
SHC adaptor protein 1provided by HGNC
Primary source
HGNC:HGNC:10840
See related
Ensembl:ENSG00000160691 MIM:600560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SHC; SHCA
Summary
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in fat (RPKM 25.3), gall bladder (RPKM 24.7) and 25 other tissues See more
Orthologs

Genomic context

See SHC1 in Genome Data Viewer
Location:
1q21.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (154962298..154974492, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154934774..154946959, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PBX homeobox interacting protein 1 Neighboring gene uncharacterized LOC101928120 Neighboring gene pygopus family PHD finger 2 Neighboring gene microRNA 4258 Neighboring gene CDC28 protein kinase regulatory subunit 1B Neighboring gene flavin adenine dinucleotide synthetase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat SHC (Src homology 2 domain containing) transforming protein 1 is upregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
tat HIV-1 Tat activates the MAPK signaling pathway leading to the phosphorylation of Shc, a protein involved in signal transduction downstream of receptor tyrosine kinase activation PubMed
tat HIV-1 Tat-induced small GTPase Ras activation is mediated by tyrosine phosphorylation of Shc and recruitment of Grb2 in human endothelial cells PubMed
nucleocapsid gag SHC (Src homology 2 domain containing) transforming protein 1 is upregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26504

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
epidermal growth factor binding IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
insulin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin-like growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
neurotrophin TRKA receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase adaptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ERBB2 signaling pathway TAS
Traceable Author Statement
more info
 
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
IRE1-mediated unfolded protein response TAS
Traceable Author Statement
more info
 
MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
MAPK cascade TAS
Traceable Author Statement
more info
 
Ras protein signal transduction TAS
Traceable Author Statement
more info
 
actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
activation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of MAPK activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-15-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-2-mediated signaling pathway TAS
Traceable Author Statement
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Ras protein signal transduction TAS
Traceable Author Statement
more info
 
positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of epidermal growth factor-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Shc-EGFR complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
SHC-transforming protein 1
Names
SH2 domain protein C1
SHC (Src homology 2 domain containing) transforming protein 1
SHC-transforming protein 3
SHC-transforming protein A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029028.1 RefSeqGene

    Range
    5108..17186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130040.2NP_001123512.1  SHC-transforming protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001123512.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    BX647149
    Consensus CDS
    CCDS44233.1
    UniProtKB/Swiss-Prot
    P29353
    Related
    ENSP00000401303.2, ENST00000448116.6
    Conserved Domains (2) summary
    cd09925
    Location:481584
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:146317
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  2. NM_001130041.2NP_001123513.1  SHC-transforming protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001123513.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' sequence and an alternate splice site in the CDS, as compared to variant 3. The resulting isoform (4), also known as p52Shc, has a shorter N-terminus and lacks an internal amino acid, as compared to isoform 3.
    Source sequence(s)
    AK292143, BC014158, X68148
    Consensus CDS
    CCDS44234.1
    UniProtKB/Swiss-Prot
    P29353
    Related
    ENSP00000357435.1, ENST00000368450.5
    Conserved Domains (2) summary
    cd09925
    Location:370473
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:36207
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  3. NM_001202859.2NP_001189788.1  SHC-transforming protein 1 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' sequence and an alternate splice site in the CDS, as compared to variant 3. The resulting isoform (5), also known as p46Shc, has a shorter N-terminus and lacks an internal amino acid, as compared to isoform 3. Variants 4 and 5 have the same nucleotide sequence, but variant 5 represents use of a downstream AUG compared to variant 4.
    Source sequence(s)
    AK292143, BC014158
    UniProtKB/Swiss-Prot
    P29353
    Related
    ENSP00000357434.4, ENST00000368449.8
    Conserved Domains (2) summary
    cd09925
    Location:325428
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:1162
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  4. NM_003029.5NP_003020.2  SHC-transforming protein 1 isoform 2

    See identical proteins and their annotated locations for NP_003020.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence, as compared to variant 3. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 3.
    Source sequence(s)
    AK292143, BC014158
    Consensus CDS
    CCDS1076.1
    UniProtKB/Swiss-Prot
    P29353
    Related
    ENSP00000357438.4, ENST00000368453.8
    Conserved Domains (2) summary
    cd09925
    Location:371474
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:36207
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  5. NM_183001.5NP_892113.4  SHC-transforming protein 1 isoform 1

    See identical proteins and their annotated locations for NP_892113.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate splice site in the CDS, as compared to variant 3. The resulting isoform (1), also known as p66Shc, lacks an internal amino acid, as compared to isoform 3.
    Source sequence(s)
    BX647149
    Consensus CDS
    CCDS30881.1
    UniProtKB/Swiss-Prot
    P29353
    Related
    ENSP00000357430.5, ENST00000368445.9
    Conserved Domains (2) summary
    cd09925
    Location:480583
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:146317
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    154962298..154974492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002083.1XP_016857572.1  SHC-transforming protein 1 isoform X11

  2. XM_011509897.1XP_011508199.1  SHC-transforming protein 1 isoform X10

    Conserved Domains (2) summary
    cd09925
    Location:362465
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:36189
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  3. XM_024449084.1XP_024304852.1  SHC-transforming protein 1 isoform X9

  4. XM_024449083.1XP_024304851.1  SHC-transforming protein 1 isoform X8

    Conserved Domains (2) summary
    cd09925
    Location:371474
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:36207
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  5. XM_017002082.2XP_016857571.1  SHC-transforming protein 1 isoform X6

  6. XM_017002081.2XP_016857570.1  SHC-transforming protein 1 isoform X5

  7. XM_011509894.3XP_011508196.1  SHC-transforming protein 1 isoform X4

    Conserved Domains (2) summary
    cd09925
    Location:472575
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:146299
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  8. XM_011509893.3XP_011508195.1  SHC-transforming protein 1 isoform X3

    Conserved Domains (2) summary
    cd09925
    Location:489592
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:146317
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  9. XM_011509892.3XP_011508194.1  SHC-transforming protein 1 isoform X2

    Conserved Domains (2) summary
    cd09925
    Location:490593
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:146317
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  10. XM_005245449.5XP_005245506.1  SHC-transforming protein 1 isoform X1

    Conserved Domains (2) summary
    cd09925
    Location:480583
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:146317
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  11. XM_011509898.2XP_011508200.1  SHC-transforming protein 1 isoform X12

    Conserved Domains (2) summary
    cd09925
    Location:314417
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:1151
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  12. XM_005245451.4XP_005245508.1  SHC-transforming protein 1 isoform X7

    See identical proteins and their annotated locations for XP_005245508.1

    Conserved Domains (2) summary
    cd09925
    Location:370473
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:36207
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
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