U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SHC1 SHC adaptor protein 1 [ Homo sapiens (human) ]

Gene ID: 6464, updated on 23-Sep-2022

Summary

Official Symbol
SHC1provided by HGNC
Official Full Name
SHC adaptor protein 1provided by HGNC
Primary source
HGNC:HGNC:10840
See related
Ensembl:ENSG00000160691 MIM:600560; AllianceGenome:HGNC:10840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SHC; SHCA
Summary
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in fat (RPKM 25.3), gall bladder (RPKM 24.7) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SHC1 in Genome Data Viewer
Location:
1q21.3
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (154962298..154974376, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (154101659..154113737, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154934774..154946852, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PBX homeobox interacting protein 1 Neighboring gene uncharacterized LOC101928120 Neighboring gene pygopus family PHD finger 2 Neighboring gene microRNA 4258 Neighboring gene CDC28 protein kinase regulatory subunit 1B Neighboring gene flavin adenine dinucleotide synthetase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat SHC (Src homology 2 domain containing) transforming protein 1 is upregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
tat HIV-1 Tat activates the MAPK signaling pathway leading to the phosphorylation of Shc, a protein involved in signal transduction downstream of receptor tyrosine kinase activation PubMed
tat HIV-1 Tat-induced small GTPase Ras activation is mediated by tyrosine phosphorylation of Shc and recruitment of Grb2 in human endothelial cells PubMed
nucleocapsid gag SHC (Src homology 2 domain containing) transforming protein 1 is upregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26504

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables epidermal growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables epidermal growth factor receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables insulin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables insulin-like growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables neurotrophin TRKA receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
enables phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase adaptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of epidermal growth factor-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of Shc-EGFR complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
SHC-transforming protein 1
Names
SH2 domain protein C1
SHC (Src homology 2 domain containing) transforming protein 1
SHC-transforming protein 3
SHC-transforming protein A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029028.1 RefSeqGene

    Range
    8737..17186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130040.2NP_001123512.1  SHC-transforming protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001123512.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    BX647149
    Consensus CDS
    CCDS44233.1
    UniProtKB/Swiss-Prot
    P29353
    Related
    ENSP00000401303.3, ENST00000448116.7
    Conserved Domains (2) summary
    cd09925
    Location:481584
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:146317
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  2. NM_001130041.2NP_001123513.1  SHC-transforming protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001123513.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' sequence and an alternate splice site in the CDS, as compared to variant 3. The resulting isoform (4), also known as p52Shc, has a shorter N-terminus and lacks an internal amino acid, as compared to isoform 3.
    Source sequence(s)
    AK292143, BC014158, X68148
    Consensus CDS
    CCDS44234.1
    UniProtKB/Swiss-Prot
    P29353
    Related
    ENSP00000357435.1, ENST00000368450.5
    Conserved Domains (2) summary
    cd09925
    Location:370473
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:36207
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  3. NM_001202859.2NP_001189788.1  SHC-transforming protein 1 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' sequence and an alternate splice site in the CDS, as compared to variant 3. The resulting isoform (5), also known as p46Shc, has a shorter N-terminus and lacks an internal amino acid, as compared to isoform 3. Variants 4 and 5 have the same nucleotide sequence, but variant 5 represents use of a downstream AUG compared to variant 4.
    Source sequence(s)
    AK292143, BC014158
    UniProtKB/Swiss-Prot
    P29353
    Related
    ENSP00000357434.4, ENST00000368449.8
    Conserved Domains (2) summary
    cd09925
    Location:325428
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:1162
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  4. NM_003029.5NP_003020.2  SHC-transforming protein 1 isoform 2

    See identical proteins and their annotated locations for NP_003020.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence, as compared to variant 3. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 3.
    Source sequence(s)
    AK292143, BC014158
    Consensus CDS
    CCDS1076.1
    UniProtKB/Swiss-Prot
    P29353
    Related
    ENSP00000357438.4, ENST00000368453.8
    Conserved Domains (2) summary
    cd09925
    Location:371474
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:36207
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  5. NM_183001.5NP_892113.4  SHC-transforming protein 1 isoform 1

    See identical proteins and their annotated locations for NP_892113.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate splice site in the CDS, as compared to variant 3. The resulting isoform (1), also known as p66Shc, lacks an internal amino acid, as compared to isoform 3.
    Source sequence(s)
    BX647149
    Consensus CDS
    CCDS30881.1
    UniProtKB/Swiss-Prot
    P29353, Q96CL1
    Related
    ENSP00000357430.5, ENST00000368445.9
    Conserved Domains (2) summary
    cd09925
    Location:480583
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:146317
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    154962298..154974376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002083.2XP_016857572.1  SHC-transforming protein 1 isoform X20

  2. XM_047427986.1XP_047283942.1  SHC-transforming protein 1 isoform X19

  3. XM_011509897.2XP_011508199.1  SHC-transforming protein 1 isoform X18

    Conserved Domains (2) summary
    cd09925
    Location:362465
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:36189
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  4. XM_047427994.1XP_047283950.1  SHC-transforming protein 1 isoform X22

  5. XM_047427991.1XP_047283947.1  SHC-transforming protein 1 isoform X21

  6. XM_047427972.1XP_047283928.1  SHC-transforming protein 1 isoform X15

  7. XM_047427970.1XP_047283926.1  SHC-transforming protein 1 isoform X14

  8. XM_047427989.1XP_047283945.1  SHC-transforming protein 1 isoform X20

  9. XM_047427988.1XP_047283944.1  SHC-transforming protein 1 isoform X19

  10. XM_047427995.1XP_047283951.1  SHC-transforming protein 1 isoform X22

  11. XM_047427982.1XP_047283938.1  SHC-transforming protein 1 isoform X17

  12. XM_047427992.1XP_047283948.1  SHC-transforming protein 1 isoform X21

  13. XM_047427974.1XP_047283930.1  SHC-transforming protein 1 isoform X16

  14. XM_047427973.1XP_047283929.1  SHC-transforming protein 1 isoform X15

  15. XM_047427971.1XP_047283927.1  SHC-transforming protein 1 isoform X14

  16. XM_047427959.1XP_047283915.1  SHC-transforming protein 1 isoform X7

  17. XM_047427958.1XP_047283914.1  SHC-transforming protein 1 isoform X4

    UniProtKB/Swiss-Prot
    Q96CL1
  18. XM_047427984.1XP_047283940.1  SHC-transforming protein 1 isoform X17

  19. XM_047427993.1XP_047283949.1  SHC-transforming protein 1 isoform X21

  20. XM_047427978.1XP_047283934.1  SHC-transforming protein 1 isoform X16

  21. XM_047427983.1XP_047283939.1  SHC-transforming protein 1 isoform X17

  22. XM_047427975.1XP_047283931.1  SHC-transforming protein 1 isoform X16

  23. XM_047427964.1XP_047283920.1  SHC-transforming protein 1 isoform X12

  24. XM_017002081.3XP_016857570.1  SHC-transforming protein 1 isoform X6

  25. XM_011509894.4XP_011508196.1  SHC-transforming protein 1 isoform X5

    Conserved Domains (2) summary
    cd09925
    Location:472575
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:146299
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  26. XM_047427963.1XP_047283919.1  SHC-transforming protein 1 isoform X11

  27. XM_047427962.1XP_047283918.1  SHC-transforming protein 1 isoform X10

  28. XM_047427961.1XP_047283917.1  SHC-transforming protein 1 isoform X9

  29. XM_011509893.4XP_011508195.1  SHC-transforming protein 1 isoform X3

    Conserved Domains (2) summary
    cd09925
    Location:489592
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:146317
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  30. XM_047427960.1XP_047283916.1  SHC-transforming protein 1 isoform X8

  31. XM_011509892.4XP_011508194.1  SHC-transforming protein 1 isoform X2

    Conserved Domains (2) summary
    cd09925
    Location:490593
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:146317
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  32. XM_005245449.6XP_005245506.1  SHC-transforming protein 1 isoform X1

    Conserved Domains (2) summary
    cd09925
    Location:480583
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:146317
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  33. XM_011509898.3XP_011508200.1  SHC-transforming protein 1 isoform X23

    Conserved Domains (2) summary
    cd09925
    Location:314417
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:1151
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  34. XM_005245451.5XP_005245508.1  SHC-transforming protein 1 isoform X13

    See identical proteins and their annotated locations for XP_005245508.1

    Conserved Domains (2) summary
    cd09925
    Location:370473
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:36207
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  35. XM_047427967.1XP_047283923.1  SHC-transforming protein 1 isoform X13

  36. XM_047427969.1XP_047283925.1  SHC-transforming protein 1 isoform X13

  37. XM_047427968.1XP_047283924.1  SHC-transforming protein 1 isoform X13

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    154101659..154113737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)