Ireb2 iron responsive element binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ireb2provided by MGI
Official Full Name: iron responsive element binding protein 2provided by MGI
Primary source: MGI:MGI:1928268
See related: Ensembl:ENSMUSG00000032293 AllianceGenome:MGI:1928268
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Irp2; D9Ertd85e
Summary: Enables iron-responsive element binding activity. Acts upstream of or within several processes, including intestinal absorption; osteoclast differentiation; and protoporphyrinogen IX biosynthetic process. Located in cytosol. Is expressed in several structures, including nervous system and yolk sac. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 14.9), CNS E14 (RPKM 13.7) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 29.81 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (54769942..54819818)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (54862658..54912534)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deubiquitylase OTUD3 prevents Parkinson's disease through stabilizing iron regulatory protein 2.
Title: Deubiquitylase OTUD3 prevents Parkinson's disease through stabilizing iron regulatory protein 2.
Iron regulatory protein 2 is required for artemether -mediated anti-hepatic fibrosis through ferroptosis pathway.
Title: Iron regulatory protein 2 is required for artemether -mediated anti-hepatic fibrosis through ferroptosis pathway.
Mdm2 is a target and mediator of IRP2 in cell growth control.
Title: Mdm2 is a target and mediator of IRP2 in cell growth control.
A critical role for Irp2 in the regulation of beta-cell iron homeostasis.
Title: Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification.
Irp2 deficiency is related to hyperglycemia, which might be due to insulin resistance rather than due to impaired insulin secretion
Title: Iron regulatory protein 2 deficiency may correlate with insulin resistance.
Increased intracellular growth due to compromised expressions of Fpn and FBXL5 by specific siRNAs reveals that Leishmania donovani uses a novel strategy of manipulating IRP2-FBXL5 axis to inhibit host Fpn expression.
Title: Leishmania donovani inhibits ferroportin translation by modulating FBXL5-IRP2 axis for its growth within host macrophages.
The Irp2(-/-) mice develop microcytic anemia, erythropoietic protoporphyria and a progressive neurological disorder, indicating that Irp2 has important functions in the nervous system and erythropoietic homeostasis
Title: Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins.
Irp2 mRNA transcription is promoted by circadian clock genes, including BMAL1, and the CLOCK heterodimer.
Title: Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression.
Irp2 increased mitochondrial iron loading and levels of cytochrome c oxidase, which led to mitochondrial dysfunction and subsequent experimental COPD.
Title: Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.
IRP1 and IRP2 mutant mice rapidly succumb to systemic infection with Salmonella Typhimurium, a pathogenic bacterium that multiplies within macrophages, with increased bacterial burdens in liver and spleen.
Title: Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C77958 (e-PCR)
- UniSTS:159879

RH126278 (e-PCR)
- UniSTS:162986

Homology

Homologs of the Ireb2 gene: The Ireb2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 497 organisms have orthologs with human gene Ireb2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables 4 iron, 4 sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables aconitate hydratase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables iron-responsive element binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables iron-responsive element binding	IDA Inferred from Direct Assay more info	PubMed
enables iron-responsive element binding	ISO Inferred from Sequence Orthology more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables regulatory region RNA binding	ISO Inferred from Sequence Orthology more info
enables translation repressor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to iron(III) ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to manganese ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mercaptoethanol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxygen-glucose deprivation	ISO Inferred from Sequence Orthology more info
involved_in citrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within erythrocyte homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intestinal absorption	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular iron ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular iron ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in osteoclast differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within post-embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protoporphyrinogen IX biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to iron(III) ion	ISO Inferred from Sequence Orthology more info
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: iron-responsive element-binding protein 2

Names: IRE-BP 2; iron regulatory protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022655.3 → NP_073146.2 iron-responsive element-binding protein 2

See identical proteins and their annotated locations for NP_073146.2

Status: VALIDATED

Source sequence(s)

AC161264, CJ093933, CK636500, CN534597, CN664620, CO431396, CV558274

Consensus CDS

CCDS23196.1

UniProtKB/Swiss-Prot

O70235, Q811J3

UniProtKB/TrEMBL

A0A8C6GDN7

Related

ENSMUSP00000034843.8, ENSMUST00000034843.9

Conserved Domains (3) summary

cd01586
Location:85 → 641

AcnA_IRP; Aconitase A catalytic domain

cd01580
Location:745 → 913

AcnA_IRP_Swivel; Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group ...

PTZ00092
Location:3 → 961

PTZ00092; aconitate hydratase-like protein; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

54769942..54819818

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155171.1 → XP_036011064.1 iron-responsive element-binding protein 2 isoform X2

Conserved Domains (1) summary

PTZ00092
Location:3 → 710

PTZ00092; aconitate hydratase-like protein; Provisional
XM_006511335.4 → XP_006511398.1 iron-responsive element-binding protein 2 isoform X1

Conserved Domains (1) summary

PTZ00092
Location:3 → 691

PTZ00092; aconitate hydratase-like protein; Provisional
XM_017313500.2 → XP_017168989.1 iron-responsive element-binding protein 2 isoform X3

Conserved Domains (1) summary

PTZ00092
Location:3 → 727

PTZ00092; aconitate hydratase-like protein; Provisional