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Ireb2 iron responsive element binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 64602, updated on 9-Mar-2023

Summary

Official Symbol
Ireb2provided by MGI
Official Full Name
iron responsive element binding protein 2provided by MGI
Primary source
MGI:MGI:1928268
See related
Ensembl:ENSMUSG00000032293 AllianceGenome:MGI:1928268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Irp2; D9Ertd85e
Summary
Enables iron-responsive element binding activity. Acts upstream of or within several processes, including intestinal absorption; osteoclast differentiation; and protoporphyrinogen IX biosynthetic process. Located in cytosol. Is expressed in several structures, including nervous system and yolk sac. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 14.9), CNS E14 (RPKM 13.7) and 23 other tissues See more
Orthologs
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Genomic context

See Ireb2 in Genome Data Viewer
Location:
9 B; 9 29.81 cM
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54769942..54819818)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (54862658..54912534)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene cellular retinoic acid binding protein I Neighboring gene RAB7, member RAS oncogene family, pseudogene 1 Neighboring gene hydroxylysine kinase 1 Neighboring gene cDNA sequence AY074887 Neighboring gene proteasome subunit alpha 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564D1164

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables aconitate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables iron-responsive element binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables iron-responsive element binding IDA
Inferred from Direct Assay
more info
PubMed 
enables iron-responsive element binding ISO
Inferred from Sequence Orthology
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables regulatory region RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables translation repressor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to iron(III) ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to manganese ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mercaptoethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxygen-glucose deprivation ISO
Inferred from Sequence Orthology
more info
 
involved_in citrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within erythrocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intestinal absorption IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intracellular iron ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within intracellular iron ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intracellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoclast differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within protoporphyrinogen IX biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to iron(III) ion ISO
Inferred from Sequence Orthology
more info
 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
iron-responsive element-binding protein 2
Names
IRE-BP 2
iron regulatory protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022655.3NP_073146.2  iron-responsive element-binding protein 2

    See identical proteins and their annotated locations for NP_073146.2

    Status: VALIDATED

    Source sequence(s)
    AC161264, CJ093933, CK636500, CN534597, CN664620, CO431396, CV558274
    Consensus CDS
    CCDS23196.1
    UniProtKB/Swiss-Prot
    O70235, Q811J3
    UniProtKB/TrEMBL
    A0A8C6GDN7
    Related
    ENSMUSP00000034843.8, ENSMUST00000034843.9
    Conserved Domains (3) summary
    cd01586
    Location:85641
    AcnA_IRP; Aconitase A catalytic domain
    cd01580
    Location:745913
    AcnA_IRP_Swivel; Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group ...
    PTZ00092
    Location:3961
    PTZ00092; aconitate hydratase-like protein; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    54769942..54819818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155171.1XP_036011064.1  iron-responsive element-binding protein 2 isoform X2

    Conserved Domains (1) summary
    PTZ00092
    Location:3710
    PTZ00092; aconitate hydratase-like protein; Provisional
  2. XM_006511335.4XP_006511398.1  iron-responsive element-binding protein 2 isoform X1

    Conserved Domains (1) summary
    PTZ00092
    Location:3691
    PTZ00092; aconitate hydratase-like protein; Provisional
  3. XM_017313500.2XP_017168989.1  iron-responsive element-binding protein 2 isoform X3

    Conserved Domains (1) summary
    PTZ00092
    Location:3727
    PTZ00092; aconitate hydratase-like protein; Provisional