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PLA2G2F phospholipase A2 group IIF [ Homo sapiens (human) ]

Gene ID: 64600, updated on 24-Nov-2020

Summary

Official Symbol
PLA2G2Fprovided by HGNC
Official Full Name
phospholipase A2 group IIFprovided by HGNC
Primary source
HGNC:HGNC:30040
See related
Ensembl:ENSG00000158786 MIM:616793
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIIFsPLA2; sPLA2-IIF
Expression
Biased expression in skin (RPKM 4.4), urinary bladder (RPKM 2.2) and 1 other tissue See more
Orthologs

Genomic context

See PLA2G2F in Genome Data Viewer
Location:
1p36.12
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (20139323..20150386)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20465823..20476879)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene prenylcysteine oxidase 1 pseudogene Neighboring gene phospholipase A2 group V Neighboring gene phospholipase A2 group IID Neighboring gene uncharacterized LOC117779438 Neighboring gene phospholipase A2 group IIC Neighboring gene UBX domain protein 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of phospholipase A2, group IIF (PLA2G2F) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed
env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ25429, FLJ36326

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase A2 activity NAS
Non-traceable Author Statement
more info
PubMed 
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
Inferred from Electronic Annotation
more info
 
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
biological_process ND
No biological Data available
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylcholine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylethanolamine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylglycerol acyl-chain remodeling IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylinositol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylserine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylserine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
group IIF secretory phospholipase A2
Names
GIIF sPLA2
phosphatidylcholine 2-acylhydrolase 2F
NP_001347798.1
NP_073730.3
XP_011540257.1
XP_011540258.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360869.2NP_001347798.1  group IIF secretory phospholipase A2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1a) reflects the use of an in-frame downstream start codon for translation, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus with a predicted signal peptide, compared to isoform 1. With the available conservation data, it is not clear which start codon is most likely used.
    Source sequence(s)
    AF306566, AK093645, AL158172, BM987713, BX647458, Z98257
    Conserved Domains (1) summary
    cd00125
    Location:21138
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  2. NM_022819.4NP_073730.3  group IIF secretory phospholipase A2 isoform 1

    See identical proteins and their annotated locations for NP_073730.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes a longer protein (isoform 1), which lacks a signal peptide. With the available conservation data, it is not clear which start codon is most likely used.
    Source sequence(s)
    AF306566, AK093645, AL158172, BM987713, BX647458, Z98257
    Consensus CDS
    CCDS204.2
    UniProtKB/Swiss-Prot
    Q9BZM2
    Related
    ENSP00000364243.3, ENST00000375102.3
    Conserved Domains (1) summary
    cd00125
    Location:64181
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    20139323..20150386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541956.1XP_011540258.1  group IIF secretory phospholipase A2 isoform X2

    See identical proteins and their annotated locations for XP_011540258.1

    UniProtKB/Swiss-Prot
    Q9BZM2
    Conserved Domains (1) summary
    cd00125
    Location:64181
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  2. XM_011541955.1XP_011540257.1  group IIF secretory phospholipase A2 isoform X1

    Conserved Domains (1) summary
    cd00125
    Location:64142
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
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