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BNC1 basonuclin 1 [ Homo sapiens (human) ]

Gene ID: 646, updated on 11-Sep-2019

Summary

Official Symbol
BNC1provided by HGNC
Official Full Name
basonuclin 1provided by HGNC
Primary source
HGNC:HGNC:1081
See related
Ensembl:ENSG00000169594 MIM:601930
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BNC; BSN1; HsT19447
Summary
The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. Alternative splicing of this gene results in multiple transcript variants, and multiple polyadenylation sites are indicated.[provided by RefSeq, Jul 2014]
Expression
Biased expression in testis (RPKM 16.5), esophagus (RPKM 5.8) and 2 other tissues See more
Orthologs

Genomic context

See BNC1 in Genome Data Viewer
Location:
15q25.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (83255884..83284664, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (83924655..83953468, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene microRNA 4515 Neighboring gene transmembrane 6 superfamily member 1 Neighboring gene HDGF like 3 Neighboring gene uncharacterized LOC105370932 Neighboring gene uncharacterized LOC105370933 Neighboring gene uncharacterized LOC105370934

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
zinc finger protein basonuclin-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301206.2NP_001288135.1  zinc finger protein basonuclin-1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC103876, AI921950, AK302992, DB051299, HY045483, L03427
    Consensus CDS
    CCDS73771.1
    UniProtKB/Swiss-Prot
    Q01954
    UniProtKB/TrEMBL
    B7Z885, F5GY04
    Related
    ENSP00000456727.1, ENST00000569704.1
    Conserved Domains (2) summary
    sd00017
    Location:352373
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:923944
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001717.4NP_001708.3  zinc finger protein basonuclin-1 isoform a

    See identical proteins and their annotated locations for NP_001708.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC103876, AI921950, CN260997, L03427
    Consensus CDS
    CCDS10324.1
    UniProtKB/Swiss-Prot
    Q01954
    Related
    ENSP00000307041.2, ENST00000345382.6
    Conserved Domains (2) summary
    sd00017
    Location:359380
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:930951
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    83255884..83284664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521893.1XP_011520195.1  zinc finger protein basonuclin-1 isoform X1

    Conserved Domains (2) summary
    sd00017
    Location:334355
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:905926
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_011521894.1XP_011520196.1  zinc finger protein basonuclin-1 isoform X2

    Conserved Domains (2) summary
    sd00017
    Location:241262
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:812833
    ZF_C2H2; C2H2 Zn finger [structural motif]
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