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GIGYF1 GRB10 interacting GYF protein 1 [ Homo sapiens (human) ]

Gene ID: 64599, updated on 4-Apr-2020

Summary

Official Symbol
GIGYF1provided by HGNC
Official Full Name
GRB10 interacting GYF protein 1provided by HGNC
Primary source
HGNC:HGNC:9126
See related
Ensembl:ENSG00000146830 MIM:612064
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GYF1; PERQ1
Summary
This gene encodes a member of the gyf family of adaptor proteins. The encoded protein contains a gyf protein interaction domain. It binds growth factor receptor bound 10, another adaptor protein that binds activated insulin-like growth factor 1 and insulin receptors and regulates receptor signaling. [provided by RefSeq, Apr 2017]
Expression
Ubiquitous expression in testis (RPKM 15.6), endometrium (RPKM 14.8) and 25 other tissues See more
Orthologs

Genomic context

See GIGYF1 in Genome Data Viewer
Location:
7q22.1
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100679507..100694250, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100277130..100286870, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375429 Neighboring gene G protein subunit beta 2 Neighboring gene CRISPRi-validated cis-regulatory element chr7.3567 Neighboring gene POP7 homolog, ribonuclease P/MRP subunit Neighboring gene erythropoietin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GRB10-interacting GYF protein 1
Names
PERQ amino acid-rich with GYF domain-containing protein 1
postmeiotic segregation increased 2-like 12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053106.1 RefSeqGene

    Range
    5033..19776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001375759.1NP_001362688.1  GRB10-interacting GYF protein 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC009488
  2. NM_001375760.1NP_001362689.1  GRB10-interacting GYF protein 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC009488
  3. NM_001375761.1NP_001362690.1  GRB10-interacting GYF protein 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC009488
  4. NM_001375762.1NP_001362691.1  GRB10-interacting GYF protein 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC009488
  5. NM_001375763.1NP_001362692.1  GRB10-interacting GYF protein 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC009488
  6. NM_001375764.1NP_001362693.1  GRB10-interacting GYF protein 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC009488
  7. NM_001375765.1NP_001362694.1  GRB10-interacting GYF protein 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC009488
    Consensus CDS
    CCDS34708.1
    Related
    ENSP00000275732.4, ENST00000275732.5
  8. NM_001375766.1NP_001362695.1  GRB10-interacting GYF protein 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC009488
    Related
    ENSP00000494292.1, ENST00000646601.1
  9. NM_001375767.1NP_001362696.1  GRB10-interacting GYF protein 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC009488
  10. NM_001375768.1NP_001362697.1  GRB10-interacting GYF protein 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC009488

RNA

  1. NR_164719.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009488

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100679507..100694250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022574.5: Suppressed sequence

    Description
    NM_022574.5: This RefSeq was removed because it retains intronic sequence.
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