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MOSPD3 motile sperm domain containing 3 [ Homo sapiens (human) ]

Gene ID: 64598, updated on 7-Jun-2020

Summary

Official Symbol
MOSPD3provided by HGNC
Official Full Name
motile sperm domain containing 3provided by HGNC
Primary source
HGNC:HGNC:25078
See related
Ensembl:ENSG00000106330 MIM:609125
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDS3; NET30
Summary
This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 10.0), adrenal (RPKM 6.8) and 25 other tissues See more
Orthologs

Genomic context

See MOSPD3 in Genome Data Viewer
Location:
7q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100612162..100615377)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100209725..100213003)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene leucine rich repeats and calponin homology domain containing 4 Neighboring gene F-box protein 24 Neighboring gene PCOLCE antisense RNA 1 Neighboring gene procollagen C-endopeptidase enhancer Neighboring gene Sharpr-MPRA regulatory region 4647 Neighboring gene transferrin receptor 2 Neighboring gene actin like 6B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FFAT motif binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
endoplasmic reticulum membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum-plasma membrane tethering IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heart development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
motile sperm domain-containing protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040097.2NP_001035186.1  motile sperm domain-containing protein 3 isoform a

    See identical proteins and their annotated locations for NP_001035186.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    AC099394, BC011653
    Consensus CDS
    CCDS5701.1
    UniProtKB/Swiss-Prot
    O75425
    Related
    ENSP00000223054.4, ENST00000223054.8
    Conserved Domains (1) summary
    pfam00635
    Location:41118
    Motile_Sperm; MSP (Major sperm protein) domain
  2. NM_001040098.1NP_001035187.1  motile sperm domain-containing protein 3 isoform a

    See identical proteins and their annotated locations for NP_001035187.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
    Source sequence(s)
    BC005042, BC011653, BQ923161
    Consensus CDS
    CCDS5701.1
    UniProtKB/Swiss-Prot
    O75425
    Related
    ENSP00000368842.2, ENST00000379527.6
    Conserved Domains (1) summary
    pfam00635
    Location:41118
    Motile_Sperm; MSP (Major sperm protein) domain
  3. NM_001040099.2NP_001035188.1  motile sperm domain-containing protein 3 isoform b

    See identical proteins and their annotated locations for NP_001035188.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform b).
    Source sequence(s)
    BC028475, BG707362
    Consensus CDS
    CCDS47662.1
    UniProtKB/Swiss-Prot
    O75425
    Related
    ENSP00000404626.2, ENST00000424091.2
    Conserved Domains (1) summary
    pfam00635
    Location:41108
    Motile_Sperm; MSP (Major sperm protein) domain
  4. NM_001363415.1NP_001350344.1  motile sperm domain-containing protein 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC099394, BE745548, CN256396
    Consensus CDS
    CCDS5701.1
    Conserved Domains (1) summary
    pfam00635
    Location:41118
    Motile_Sperm; MSP (Major sperm protein) domain
  5. NM_001363416.1NP_001350345.1  motile sperm domain-containing protein 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC099394, CN256396, HY025137
    Consensus CDS
    CCDS5701.1
    Conserved Domains (1) summary
    pfam00635
    Location:41118
    Motile_Sperm; MSP (Major sperm protein) domain
  6. NM_023948.5NP_076438.1  motile sperm domain-containing protein 3 isoform a

    See identical proteins and their annotated locations for NP_076438.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2 and 3 encode the same isoform.
    Source sequence(s)
    BC011653
    Consensus CDS
    CCDS5701.1
    UniProtKB/Swiss-Prot
    O75425
    Related
    ENSP00000377522.2, ENST00000393950.7
    Conserved Domains (1) summary
    pfam00635
    Location:41118
    Motile_Sperm; MSP (Major sperm protein) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100612162..100615377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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