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USP17L3 ubiquitin specific peptidase 17 like family member 3 [ Homo sapiens (human) ]

Gene ID: 645836, updated on 13-May-2022

Summary

Official Symbol
USP17L3provided by HGNC
Official Full Name
ubiquitin specific peptidase 17 like family member 3provided by HGNC
Primary source
HGNC:HGNC:37175
See related
Ensembl:ENSG00000225327 AllianceGenome:HGNC:37175
Gene type
protein coding
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
USP17B; USP17F
Summary
Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination and regulation of apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: This gene contains an intact open reading frame; however, it is classified as a pseudogene because no transcripts available as of August 2009 are thought to originate from this location, suggesting that this gene does not have a functional promoter. [26 Aug 2009]
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Genomic context

See USP17L3 in Genome Data Viewer
Location:
8p23.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (7976393..7977985, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (12122357..12123949, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (7833915..7835507, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene ubiquitin carboxyl-terminal hydrolase 17-like protein 2-like Neighboring gene family with sequence similarity 66 member E Neighboring gene ubiquitin specific peptidase 17 like family member 8 Neighboring gene defensin beta 109C Neighboring gene family with sequence similarity 90, member A11

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 17-like protein 3
Names
deubiquitinating enzyme 17-like protein 3
ubiquitin specific peptidase 17-like 3
ubiquitin thioesterase 17-like protein 3
ubiquitin-specific-processing protease 17-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256871.1NP_001243800.1  ubiquitin carboxyl-terminal hydrolase 17-like protein 3

    See identical proteins and their annotated locations for NP_001243800.1

    Status: INFERRED

    Source sequence(s)
    AC130365
    Consensus CDS
    CCDS78301.1
    UniProtKB/Swiss-Prot
    A6NCW0
    Related
    ENSP00000485323.1, ENST00000530484.1
    Conserved Domains (3) summary
    cd02661
    Location:79373
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:80372
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam04774
    Location:426454
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    7976393..7977985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p14 PATCHES

    Range
    885400..886992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    12122357..12123949 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_012787.1: Suppressed sequence

    Description
    NG_012787.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.