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NDST4 N-deacetylase and N-sulfotransferase 4 [ Homo sapiens (human) ]

Gene ID: 64579, updated on 1-Jun-2020

Summary

Official Symbol
NDST4provided by HGNC
Official Full Name
N-deacetylase and N-sulfotransferase 4provided by HGNC
Primary source
HGNC:HGNC:20779
See related
Ensembl:ENSG00000138653 MIM:615039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
N-HSST; NDST-4; NHSST4; N-HSST 4
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See NDST4 in Genome Data Viewer
Location:
4q26
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (114824122..115114133, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (115748931..116035032, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377382 Neighboring gene RNA, 7SL, cytoplasmic 808, pseudogene Neighboring gene mitochondrial ribosomal protein S33 pseudogene 3 Neighboring gene ribosome production factor 2 homolog pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
NHGRI GWA Catalog
Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.
NHGRI GWA Catalog

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
[heparan sulfate]-glucosamine N-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heparin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
Names
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
N-deacetylase/N-sulfotransferase 4
N-heparan sulfate sulfotransferase 4
glucosaminyl N-deacetylase/N-sulfotransferase 4
NP_072091.1
XP_016864034.1
XP_016864035.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022569.3NP_072091.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

    See identical proteins and their annotated locations for NP_072091.1

    Status: VALIDATED

    Source sequence(s)
    AB036429, AC110777, AK289670, BC012326
    Consensus CDS
    CCDS3706.1
    UniProtKB/Swiss-Prot
    Q9H3R1
    UniProtKB/TrEMBL
    A8K0V5
    Related
    ENSP00000264363.2, ENST00000264363.7
    Conserved Domains (2) summary
    pfam00685
    Location:594845
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:20505
    HSNSD; heparan sulfate-N-deacetylase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    114824122..115114133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008545.2XP_016864034.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 isoform X1

  2. XM_017008546.1XP_016864035.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 isoform X1

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