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NDST4 N-deacetylase and N-sulfotransferase 4 [ Homo sapiens (human) ]

Gene ID: 64579, updated on 22-Sep-2022

Summary

Official Symbol
NDST4provided by HGNC
Official Full Name
N-deacetylase and N-sulfotransferase 4provided by HGNC
Primary source
HGNC:HGNC:20779
See related
Ensembl:ENSG00000138653 MIM:615039; AllianceGenome:HGNC:20779
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
N-HSST; NDST-4; NHSST4; N-HSST 4
Summary
Predicted to enable [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See NDST4 in Genome Data Viewer
Location:
4q26
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (114827763..115113620, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (118130762..118416573, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (115748919..116034776, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900763 Neighboring gene uncharacterized LOC105377382 Neighboring gene RNA, 7SL, cytoplasmic 808, pseudogene Neighboring gene uncharacterized LOC124900764 Neighboring gene mitochondrial ribosomal protein S33 pseudogene 3 Neighboring gene ribosome production factor 2 homolog pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
EBI GWAS Catalog
Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acetylglucosamine deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
enables [heparan sulfate]-glucosamine N-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
Names
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
N-deacetylase/N-sulfotransferase 4
N-heparan sulfate sulfotransferase 4
glucosaminyl N-deacetylase/N-sulfotransferase 4
NP_072091.1
XP_016864034.1
XP_016864035.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022569.3NP_072091.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

    See identical proteins and their annotated locations for NP_072091.1

    Status: VALIDATED

    Source sequence(s)
    AB036429, AC110777, AK289670, BC012326
    Consensus CDS
    CCDS3706.1
    UniProtKB/Swiss-Prot
    Q2KHM8, Q9H3R1
    UniProtKB/TrEMBL
    A8K0V5
    Related
    ENSP00000264363.2, ENST00000264363.7
    Conserved Domains (2) summary
    pfam00685
    Location:594845
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:20505
    HSNSD; heparan sulfate-N-deacetylase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    114827763..115113620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008545.3XP_016864034.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 isoform X1

  2. XM_017008546.2XP_016864035.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    118130762..118416573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)