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Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64562, updated on 9-Sep-2018

Summary

Official Symbol
Prkab2provided by RGD
Official Full Name
protein kinase AMP-activated non-catalytic subunit beta 2provided by RGD
Primary source
RGD:620905
See related
Ensembl:ENSRNOG00000018166
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
a component of the AMPK alpha2beta2gamma1 complex which phosphorylates glycogen synthase [RGD, Feb 2006]
Expression
Biased expression in Muscle (RPKM 427.2), Heart (RPKM 86.6) and 8 other tissues See more
Orthologs

Genomic context

See Prkab2 in Genome Data Viewer
Location:
2q34
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (199831990..199847623)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (219309807..219325389)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 1-like Neighboring gene flavin containing monooxygenase 5 Neighboring gene uncharacterized LOC102550575 Neighboring gene transfer RNA glutamine (anticodon CUG) Neighboring gene phosphodiesterase 4D interacting protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Homology

Clone Names

  • MGC93432

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to AMP-activated protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to AMP-activated protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to AMP-activated protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleotide-activated protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide-activated protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide-activated protein kinase complex IEA
Inferred from Electronic Annotation
more info
 
nucleotide-activated protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
5'-AMP-activated protein kinase subunit beta-2
Names
AMP-activated protein kinase beta-2 regulatory subunit
AMPK beta-2 chain
AMPK subunit beta-2
protein kinase, AMP-activated, beta 2 non-catalytic subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022627.2NP_072149.1  5'-AMP-activated protein kinase subunit beta-2

    See identical proteins and their annotated locations for NP_072149.1

    Status: PROVISIONAL

    Source sequence(s)
    AF182717
    UniProtKB/Swiss-Prot
    Q9QZH4
    Conserved Domains (2) summary
    smart01010
    Location:182271
    AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
    pfam16561
    Location:77160
    AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    199831990..199847623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233011.2XP_006233073.1  5'-AMP-activated protein kinase subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_006233073.1

    UniProtKB/TrEMBL
    A0A0G2JVK3
    Related
    ENSRNOP00000069519.1, ENSRNOT00000086588.1
    Conserved Domains (2) summary
    smart01010
    Location:182271
    AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
    pfam16561
    Location:77157
    AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase
  2. XM_006233012.2XP_006233074.1  5'-AMP-activated protein kinase subunit beta-2 isoform X1

    See identical proteins and their annotated locations for XP_006233074.1

    UniProtKB/TrEMBL
    A0A0G2JVK3
    Conserved Domains (2) summary
    smart01010
    Location:182271
    AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
    pfam16561
    Location:77157
    AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    177749772..177761966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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