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Mpeg1 macrophage expressed 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64552, updated on 24-Jul-2021

Summary

Official Symbol
Mpeg1provided by RGD
Official Full Name
macrophage expressed 1provided by RGD
Primary source
RGD:69275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
P-2; Mpg-1
Summary
may be involved in the pathogenesis of disease related renal injury [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 829.7), Liver (RPKM 558.1) and 8 other tissues See more
Orthologs
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Genomic context

See Mpeg1 in Genome Data Viewer
Location:
1q43
Exon count:
2
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (209452176..209456692)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (228724559..228729054)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor 337 Neighboring gene pore forming protein-like Neighboring gene deltex E3 ubiquitin ligase 4 Neighboring gene FAM111A pseudogene Neighboring gene hypothetical protein LOC691074

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-negative bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-positive bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in pore formation in membrane of other organism ISO
Inferred from Sequence Orthology
more info
 
involved_in pore formation in membrane of other organism ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
macrophage-expressed gene 1 protein
Names
perforin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305460.1NP_001292389.1  macrophage-expressed gene 1 protein precursor

    See identical proteins and their annotated locations for NP_001292389.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI511268, JACYVU010000046
    Conserved Domains (1) summary
    pfam01823
    Location:132348
    MACPF; MAC/Perforin domain
  2. NM_022617.2NP_072139.2  macrophage-expressed gene 1 protein precursor

    See identical proteins and their annotated locations for NP_072139.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI511268, JACYVU010000046
    Conserved Domains (1) summary
    pfam01823
    Location:132348
    MACPF; MAC/Perforin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    209452176..209456692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008760261.2XP_008758483.1  macrophage-expressed gene 1 protein isoform X1

    See identical proteins and their annotated locations for XP_008758483.1

    Conserved Domains (1) summary
    pfam01823
    Location:132348
    MACPF; MAC/Perforin domain
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