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Bcl2l11 BCL2 like 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64547, updated on 12-Aug-2018

Summary

Official Symbol
Bcl2l11provided by RGD
Official Full Name
BCL2 like 11provided by RGD
Primary source
RGD:628774
See related
Ensembl:ENSRNOG00000016551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Bim; Bod; BimL
Summary
proapototic Bcl-2 related protein that interacts with anti-apoptotic Bcl-2 family members to play a role in regulation of apoptosis [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 60.4), Spleen (RPKM 47.5) and 9 other tissues See more
Orthologs

Genomic context

See Bcl2l11 in Genome Data Viewer
Location:
3q36
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (120726906..120764192)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (126567484..126604461, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene BUB1 mitotic checkpoint serine/threonine kinase Neighboring gene acyl-CoA oxidase-like Neighboring gene uncharacterized LOC102555660 Neighboring gene small nuclear ribonucleoprotein F-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
dynein complex binding IEA
Inferred from Electronic Annotation
more info
 
dynein complex binding ISO
Inferred from Sequence Orthology
more info
 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to microtubule binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
B cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
B cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
B cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
T cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
apoptotic process involved in embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process involved in embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
cellular process regulating host cell cycle in response to virus IEA
Inferred from Electronic Annotation
more info
 
cellular process regulating host cell cycle in response to virus ISO
Inferred from Sequence Orthology
more info
 
developmental pigmentation IEA
Inferred from Electronic Annotation
more info
 
developmental pigmentation ISO
Inferred from Sequence Orthology
more info
 
ear development IEA
Inferred from Electronic Annotation
more info
 
ear development ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
kidney development IEA
Inferred from Electronic Annotation
more info
 
kidney development ISO
Inferred from Sequence Orthology
more info
 
leukocyte homeostasis ISO
Inferred from Sequence Orthology
more info
 
lymphocyte homeostasis ISO
Inferred from Sequence Orthology
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
male gonad development ISO
Inferred from Sequence Orthology
more info
 
mammary gland development IEA
Inferred from Electronic Annotation
more info
 
mammary gland development ISO
Inferred from Sequence Orthology
more info
 
myeloid cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
myeloid cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process by virus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process by virus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fibroblast apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitochondrial membrane permeability involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitochondrial membrane permeability involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
positive regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
post-embryonic animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
post-embryonic animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
post-embryonic development ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of developmental pigmentation IEA
Inferred from Electronic Annotation
more info
 
regulation of developmental pigmentation ISO
Inferred from Sequence Orthology
more info
 
regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
regulation of organ growth ISO
Inferred from Sequence Orthology
more info
 
response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
spleen development IEA
Inferred from Electronic Annotation
more info
 
spleen development ISO
Inferred from Sequence Orthology
more info
 
thymocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
thymocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
thymus development IEA
Inferred from Electronic Annotation
more info
 
thymus development ISO
Inferred from Sequence Orthology
more info
 
tube formation IEA
Inferred from Electronic Annotation
more info
 
tube formation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
BIM-BCL-2 complex ISO
Inferred from Sequence Orthology
more info
 
BIM-BCL-xl complex ISO
Inferred from Sequence Orthology
more info
 
Bcl-2 family protein complex IEA
Inferred from Electronic Annotation
more info
 
Bcl-2 family protein complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of membrane IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
bcl-2-like protein 11
Names
BCL2-like 11 (apoptosis facilitator)
Bcl-2 related apoptotic gene product BimL
bcl-2-related ovarian death protein
bcl2-interacting mediator of cell death

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_171988.2NP_741985.1  bcl-2-like protein 11

    See identical proteins and their annotated locations for NP_741985.1

    Status: VALIDATED

    Source sequence(s)
    AC111715, AF065433
    UniProtKB/Swiss-Prot
    O88498
    Related
    ENSRNOP00000039006.4, ENSRNOT00000051069.5
    Conserved Domains (2) summary
    pfam06773
    Location:439
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:128162
    Bclx_interact; Bcl-x interacting, BH3 domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    120726906..120764192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234983.3XP_006235045.2  bcl-2-like protein 11 isoform X1

    Conserved Domains (2) summary
    pfam06773
    Location:111146
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:235269
    Bclx_interact; Bcl-x interacting, BH3 domain
  2. XM_006234985.3XP_006235047.2  bcl-2-like protein 11 isoform X2

    Conserved Domains (2) summary
    pfam06773
    Location:111146
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:179213
    Bclx_interact; Bcl-x interacting, BH3 domain
  3. XM_006234987.3XP_006235049.2  bcl-2-like protein 11 isoform X3

    Conserved Domains (2) summary
    pfam06773
    Location:111146
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:149183
    Bclx_interact; Bcl-x interacting, BH3 domain

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    114200283..114237903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022612.1: Suppressed sequence

    Description
    NM_022612.1: This RefSeq was removed because it is thought to be a partial splice structure.
  2. NM_171989.1: Suppressed sequence

    Description
    NM_171989.1: This RefSeq was removed because it is thought to be a partial splice structure.
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