Il12b interleukin 12B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il12bprovided by RGD
Official Full Name: interleukin 12Bprovided by RGD
Primary source: RGD:628704
See related: Ensembl:ENSRNOG00000004380 AllianceGenome:RGD:628704
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Il12
Summary: Enables interleukin-12 alpha subunit binding activity. Involved in natural killer cell activation involved in immune response. Located in extracellular space. Part of interleukin-12 complex. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Orthologous to human IL12B (interleukin 12B). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Thymus (RPKM 25.2), Spleen (RPKM 18.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 10q21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (29390300..29405194)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (28888832..28903802)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (30034447..30048774)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet.
Title: A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet.
Data show that treated rats exhibited the lowest degree of inflammatory infiltration of the spinal cord, as well as the lowest levels of nuclear factor kappa B, interleukin-12 and interferon-gamma.
Title: Variable effects of cyclophosphamide in rodent models of experimental allergic encephalomyelitis.
IL-12 normalizes both p38 and ERK activation in T cells, but the restoration of ERK plays a predominant role in IL-12-mediated restoration of T cell IL-2 and IFN-gamma production after EtOH and burn injury.
Title: ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-gamma in a rodent model of alcohol intoxication and burn injury.
Measles virus infection leads to a decrease in IL-12 secretion and an increase in IL-4 secretion, but this does not correlate with immune suppression.
Title: Cytokine imbalance after measles virus infection has no correlation with immune suppression.
Data present the upregulation of IFN-gamma by Leuconostoc mesenteroides under pro-Th2 conditions and the requirement of NF-kappaB, p38 and JNK for IL-12 production.
Title: Induction of Th1 cytokines by Leuconostoc mesenteroides subsp. mesenteroides (KCTC 3100) under Th2-type conditions and the requirement of NF-kappaB and p38/JNK.
regulatory T cells downregulated CD25(-)CD4(+) T-cell-mediated production of IL-12 from antigen-presenting cells
Title: Downregulation of IL-12 and a novel negative feedback system mediated by CD25+CD4+ T cells.
CpG DNA (model for LPS peptides) induced IL-12 p40 secretion by macrophages from mice with either disrupted STAT1 or ICSBP genes
Title: CpG DNA induced IL-12 p40 gene activation is independent of STAT1 activation or production of interferon consensus sequence binding protein.
autoimmune-resistant strains were associated with a higher production of proinflammatory mediators, a classical activation phenotype, and preferential induction of IL-12.
Title: Differential macrophage expression of IL-12 and IL-23 upon innate immune activation defines rat autoimmune susceptibility.
co-culture of DCs with fixed tumor cells augments the secretion of IL-12 by DCs and these activated DCs upon co-culture with naive NK cells enhance the cytolytic activity of NK; IL-12 secreted by DCs is an essential factor in NK cell activation
Title: Interleukin-12 secreted by mature dendritic cells mediates activation of NK cell function.
Up-regulation of IL-18 and IL-12 in the ileum of neonatal rats with necrotizing enterocolitis.
Title: Up-regulation of IL-18 and IL-12 in the ileum of neonatal rats with necrotizing enterocolitis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
contributes_to cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to cytokine receptor binding	ISO Inferred from Sequence Orthology more info
contributes_to growth factor activity	IEA Inferred from Electronic Annotation more info
contributes_to growth factor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables interleukin-12 alpha subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-12 alpha subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-12 alpha subunit binding	IEA Inferred from Electronic Annotation more info
enables interleukin-12 alpha subunit binding	ISO Inferred from Sequence Orthology more info
enables interleukin-12 receptor binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to interleukin-23 receptor binding	IEA Inferred from Electronic Annotation more info
contributes_to interleukin-23 receptor binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T-helper 1 cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T-helper 1 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T-helper cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in T-helper cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to protozoan	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in interleukin-12-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-12-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within interleukin-12-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-12-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell activation	IEA Inferred from Electronic Annotation more info
involved_in natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-17 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of negative regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NK T cell activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NK T cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NK T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NK T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 type immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T-helper 1 type immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-17 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lymphocyte mediated immunity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lymphocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lymphocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mononuclear cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mononuclear cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in response to UV-B	IEA Inferred from Electronic Annotation more info
involved_in response to UV-B	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in endosome lumen	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of interleukin-12 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of interleukin-12 complex	IDA Inferred from Direct Assay more info	PubMed
part_of interleukin-12 complex	IEA Inferred from Electronic Annotation more info
part_of interleukin-12 complex	ISO Inferred from Sequence Orthology more info
part_of interleukin-23 complex	IEA Inferred from Electronic Annotation more info
part_of interleukin-23 complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-12 subunit beta

Names: interleukin-12 p40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.