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ARRDC5 arrestin domain containing 5 [ Homo sapiens (human) ]

Gene ID: 645432, updated on 26-Oct-2022

Summary

Official Symbol
ARRDC5provided by HGNC
Official Full Name
arrestin domain containing 5provided by HGNC
Primary source
HGNC:HGNC:31407
See related
Ensembl:ENSG00000205784 AllianceGenome:HGNC:31407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ubiquitin ligase-substrate adaptor activity and ubiquitin protein ligase binding activity. Predicted to be involved in protein transport. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 6.0), spleen (RPKM 1.1) and 12 other tissues See more
Orthologs
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Genomic context

See ARRDC5 in Genome Data Viewer
Location:
19p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4890437..4916820, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4875655..4888115, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4890449..4902908, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene perilipin 3 Neighboring gene CRISPRi-validated cis-regulatory element chr19.1096 Neighboring gene ubiquitin like with PHD and ring finger domains 1 Neighboring gene microRNA 4747 Neighboring gene lysine demethylase 4B Neighboring gene Sharpr-MPRA regulatory region 13405

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
arrestin domain-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080523.3NP_001073992.2  arrestin domain-containing protein 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and uses an alternate in-frame splice site in the 5'-CDS, compared to variant 1. It encodes isoform 2, which has the same N- and C- termini, but is shorter, compared to isoform 1.
    Source sequence(s)
    AC027319
    Consensus CDS
    CCDS45929.2
    UniProtKB/TrEMBL
    A0A494BZV3
    Related
    ENSP00000498235.1, ENST00000650722.2
    Conserved Domains (2) summary
    pfam02752
    Location:170304
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:13124
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. NM_001367189.2NP_001354118.1  arrestin domain-containing protein 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC027319
    Conserved Domains (2) summary
    pfam02752
    Location:192326
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:13146
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    4890437..4916820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528181.3XP_011526483.1  arrestin domain-containing protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011526483.1

    Conserved Domains (1) summary
    pfam02752
    Location:46180
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
  2. XM_047439220.1XP_047295176.1  arrestin domain-containing protein 5 isoform X1

  3. XM_047439221.1XP_047295177.1  arrestin domain-containing protein 5 isoform X2

  4. XM_005259616.3XP_005259673.1  arrestin domain-containing protein 5 isoform X1

    See identical proteins and their annotated locations for XP_005259673.1

    Conserved Domains (1) summary
    pfam02752
    Location:46180
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    4875655..4888115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)