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ARRDC5 arrestin domain containing 5 [ Homo sapiens (human) ]

Gene ID: 645432, updated on 21-Dec-2019

Summary

Official Symbol
ARRDC5provided by HGNC
Official Full Name
arrestin domain containing 5provided by HGNC
Primary source
HGNC:HGNC:31407
See related
Ensembl:ENSG00000205784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 6.0), spleen (RPKM 1.1) and 12 other tissues See more
Orthologs

Genomic context

See ARRDC5 in Genome Data Viewer
Location:
19p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (4867614..4915469, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4890449..4902879, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene fem-1 homolog A Neighboring gene toll like receptor adaptor molecule 1 Neighboring gene CRISPRi-validated cis-regulatory element chr19.1096 Neighboring gene perilipin 3 Neighboring gene ubiquitin like with PHD and ring finger domains 1 Neighboring gene microRNA 4747 Neighboring gene lysine demethylase 4B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

General protein information

Preferred Names
arrestin domain-containing protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080523.3NP_001073992.2  arrestin domain-containing protein 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and uses an alternate in-frame splice site in the 5'-CDS, compared to variant 1. It encodes isoform 2, which has the same N- and C- termini, but is shorter, compared to isoform 1.
    Source sequence(s)
    AC027319
    Consensus CDS
    CCDS45929.1
    Related
    ENSP00000498235.1, ENST00000650722.2
    Conserved Domains (2) summary
    pfam02752
    Location:170304
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:13124
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
  2. NM_001367189.2NP_001354118.1  arrestin domain-containing protein 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC027319
    Conserved Domains (2) summary
    pfam02752
    Location:192326
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:13146
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    4867614..4915469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027144.1XP_016882633.1  arrestin domain-containing protein 5 isoform X3

  2. XM_017027145.1XP_016882634.1  arrestin domain-containing protein 5 isoform X4

  3. XM_011528181.2XP_011526483.1  arrestin domain-containing protein 5 isoform X2

    See identical proteins and their annotated locations for XP_011526483.1

    Conserved Domains (1) summary
    pfam02752
    Location:46180
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
  4. XM_005259616.2XP_005259673.1  arrestin domain-containing protein 5 isoform X2

    See identical proteins and their annotated locations for XP_005259673.1

    Conserved Domains (1) summary
    pfam02752
    Location:46180
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
  5. XM_024451651.1XP_024307419.1  arrestin domain-containing protein 5 isoform X2

    Conserved Domains (1) summary
    pfam02752
    Location:46180
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
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