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Pim3 Pim-3 proto-oncogene, serine/threonine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 64534, updated on 10-Jul-2024

Summary

Official Symbol
Pim3provided by RGD
Official Full Name
Pim-3 proto-oncogene, serine/threonine kinaseprovided by RGD
Primary source
RGD:620462
See related
EnsemblRapid:ENSRNOG00000029698 AllianceGenome:RGD:620462
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein serine/threonine kinase activity. Involved in histone phosphorylation and protein autophosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human PIM3 (Pim-3 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 195.9), Heart (RPKM 170.2) and 9 other tissues See more
Orthologs
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Genomic context

See Pim3 in Genome Data Viewer
Location:
7q34
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (121822076..121836257)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (119953377..119956587)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (129856467..129863441)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ALG12, alpha-1,6-mannosyltransferase Neighboring gene cysteine-rich with EGF-like domains 2 Neighboring gene transfer RNA leucine (anticodon AAG) 11 Neighboring gene uncharacterized LOC134479954 Neighboring gene tubulin tyrosine ligase like 8 Neighboring gene uncharacterized LOC134479953 Neighboring gene modulator of VRAC current 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to forskolin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase pim-3
Names
kinase induced by depolarization
pim-3 oncogene
protein kinase Kid-1
proviral integration site 3
serine threonine kinase pim3
serine threonine kinase-like
NP_072124.1
XP_063120283.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022602.1NP_072124.1  serine/threonine-protein kinase pim-3

    See identical proteins and their annotated locations for NP_072124.1

    Status: PROVISIONAL

    Source sequence(s)
    AF057026
    UniProtKB/Swiss-Prot
    O70444
    UniProtKB/TrEMBL
    A0A0G2K399, Q4V8M2
    Related
    ENSRNOP00000072553.2, ENSRNOT00000085835.3
    Conserved Domains (1) summary
    cl21453
    Location:39293
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    121822076..121836257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264213.1XP_063120283.1  serine/threonine-protein kinase pim-3 isoform X1

    UniProtKB/Swiss-Prot
    O70444
    UniProtKB/TrEMBL
    A0A0G2K399, Q4V8M2