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LINGO3 leucine rich repeat and Ig domain containing 3 [ Homo sapiens (human) ]

Gene ID: 645191, updated on 23-Nov-2021

Summary

Official Symbol
LINGO3provided by HGNC
Official Full Name
leucine rich repeat and Ig domain containing 3provided by HGNC
Primary source
HGNC:HGNC:21206
See related
Ensembl:ENSG00000220008 MIM:609792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LERN2; LRRN6B
Expression
Biased expression in spleen (RPKM 1.7), brain (RPKM 0.7) and 7 other tissues See more
Orthologs
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Genomic context

See LINGO3 in Genome Data Viewer
Location:
19p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (2287164..2308154, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2289783..2308153, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ornithine decarboxylase antizyme 1 Neighboring gene PEAK family member 3 Neighboring gene uncharacterized LOC101928572 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene signal peptide peptidase like 2B Neighboring gene transmembrane serine protease 9 Neighboring gene translocase of inner mitochondrial membrane 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Clone Names

  • FLJ34476

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3
Names
leucine rich repeat neuronal 6B
leucine-rich repeat neuronal protein 2
leucine-rich repeat neuronal protein 6B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101391.3NP_001094861.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 precursor

    See identical proteins and their annotated locations for NP_001094861.1

    Status: VALIDATED

    Source sequence(s)
    AC004152, AC005258
    Consensus CDS
    CCDS45905.1
    UniProtKB/Swiss-Prot
    P0C6S8
    Related
    ENSP00000467753.2, ENST00000585527.1
    Conserved Domains (7) summary
    smart00013
    Location:2458
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:111286
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:407497
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:5979
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:5995
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:247303
    LRR_8; Leucine rich repeat
    cl11960
    Location:422490
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    2287164..2308154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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