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TEKT3 tektin 3 [ Homo sapiens (human) ]

Gene ID: 64518, updated on 5-Aug-2022

Summary

Official Symbol
TEKT3provided by HGNC
Official Full Name
tektin 3provided by HGNC
Primary source
HGNC:HGNC:14293
See related
Ensembl:ENSG00000125409 MIM:612683; AllianceGenome:HGNC:14293
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 5.3) See more
Orthologs
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Genomic context

See TEKT3 in Genome Data Viewer
Location:
17p12
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (15303812..15343671, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (15209840..15247627, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (15207129..15244914, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903931 Neighboring gene peripheral myelin protein 22 Neighboring gene microRNA 4731 Neighboring gene uncharacterized LOC124903932 Neighboring gene RNA, U6 small nuclear 799, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 792, pseudogene Neighboring gene TVP23C-CDRT4 readthrough Neighboring gene CMT1A duplicated region transcript 4 Neighboring gene ribosomal protein L9 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32828

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_positive_effect regulation of brood size ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in acrosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in axonemal microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus HDA PubMed 
located_in outer acrosomal membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
tektin-3
Names
testicular microtubules-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031898.3NP_114104.1  tektin-3

    See identical proteins and their annotated locations for NP_114104.1

    Status: REVIEWED

    Source sequence(s)
    AF334676, BC031688
    Consensus CDS
    CCDS11169.1
    UniProtKB/Swiss-Prot
    Q96M48, Q9BXF9
    Related
    ENSP00000379263.1, ENST00000395930.6
    Conserved Domains (1) summary
    pfam03148
    Location:99478
    Tektin; Tektin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    15303812..15343671 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024954.2XP_016880443.1  tektin-3 isoform X1

    UniProtKB/Swiss-Prot
    Q96M48, Q9BXF9
    Conserved Domains (1) summary
    pfam03148
    Location:99478
    Tektin; Tektin family
  2. XM_011523989.2XP_011522291.1  tektin-3 isoform X1

    See identical proteins and their annotated locations for XP_011522291.1

    UniProtKB/Swiss-Prot
    Q96M48, Q9BXF9
    Related
    ENSP00000343995.2, ENST00000338696.6
    Conserved Domains (1) summary
    pfam03148
    Location:99478
    Tektin; Tektin family
  3. XM_017024955.2XP_016880444.1  tektin-3 isoform X2

    Conserved Domains (1) summary
    pfam03148
    Location:1312
    Tektin; Tektin family
  4. XM_011523990.3XP_011522292.1  tektin-3 isoform X2

    Conserved Domains (1) summary
    pfam03148
    Location:1312
    Tektin; Tektin family
  5. XM_011523988.3XP_011522290.1  tektin-3 isoform X1

    See identical proteins and their annotated locations for XP_011522290.1

    UniProtKB/Swiss-Prot
    Q96M48, Q9BXF9
    Conserved Domains (1) summary
    pfam03148
    Location:99478
    Tektin; Tektin family
  6. XM_017024956.2XP_016880445.1  tektin-3 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    15209840..15247627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)