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CCNI2 cyclin I family member 2 [ Homo sapiens (human) ]

Gene ID: 645121, updated on 6-Sep-2022

Summary

Official Symbol
CCNI2provided by HGNC
Official Full Name
cyclin I family member 2provided by HGNC
Primary source
HGNC:HGNC:33869
See related
Ensembl:ENSG00000205089 AllianceGenome:HGNC:33869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 13.3), adrenal (RPKM 2.6) and 18 other tissues See more
Orthologs
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Genomic context

See CCNI2 in Genome Data Viewer
Location:
5q31.1
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (132747426..132756065)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (133267163..133274140)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132083118..132090095)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379176 Neighboring gene interleukin 4 Neighboring gene kinesin family member 3A Neighboring gene septin 8 Neighboring gene Sharpr-MPRA regulatory region 2681 Neighboring gene sosondowah ankyrin repeat domain family member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16793

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039780.4NP_001034869.1  cyclin-I2 isoform 2

    See identical proteins and their annotated locations for NP_001034869.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC004775, AK131553, AW131382
    Consensus CDS
    CCDS34236.1
    UniProtKB/Swiss-Prot
    B7ZMB8, Q6ZMN8
    Related
    ENSP00000368005.1, ENST00000378731.6
    Conserved Domains (2) summary
    pfam00134
    Location:156247
    Cyclin_N; Cyclin, N-terminal domain
    cl26386
    Location:3111
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
  2. NM_001287252.2NP_001274181.1  cyclin-I2 isoform 1

    See identical proteins and their annotated locations for NP_001274181.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC004775, AK131553, AW131382, BC144417
    Consensus CDS
    CCDS75297.1
    UniProtKB/Swiss-Prot
    Q6ZMN8
    Related
    ENSP00000478257.1, ENST00000614847.1
    Conserved Domains (1) summary
    pfam00134
    Location:156247
    Cyclin_N; Cyclin, N-terminal domain
  3. NM_001287253.2NP_001274182.1  cyclin-I2 isoform 3

    See identical proteins and their annotated locations for NP_001274182.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AC004775, AK131553, AW131382, BC144416
    UniProtKB/Swiss-Prot
    Q6ZMN8
    Conserved Domains (1) summary
    pfam00134
    Location:157248
    Cyclin_N; Cyclin, N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    132747426..132756065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417523.1XP_047273479.1  cyclin-I2 isoform X3

  2. XM_047417522.1XP_047273478.1  cyclin-I2 isoform X2

  3. XM_047417521.1XP_047273477.1  cyclin-I2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    133267163..133274140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)