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Fzd2 frizzled class receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64512, updated on 30-Jul-2025
Official Symbol
Fzd2provided by RGD
Official Full Name
frizzled class receptor 2provided by RGD
Primary source
RGD:71012
See related
Ensembl:ENSRNOG00000021962 AllianceGenome:RGD:71012
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fz-10; Fzd10
Summary
Enables Wnt receptor activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; Wnt signaling pathway; and cellular response to vitamin D. Located in plasma membrane. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in omodysplasia 2. Orthologous to human FZD2 (frizzled class receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
human mouse all
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See Fzd2 in Genome Data Viewer
Location:
10q32.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88061988..88063898)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87561866..87563776)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (90550147..90552057)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene uncharacterized LOC102550111 Neighboring gene ATPase H+ transporting V0 subunit C, pseudogene 1 Neighboring gene meiosis specific with coiled-coil domain

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Suppression of rat Frizzled-2 attenuates hypoxia/reoxygenation-induced Ca2+ accumulation in rat H9c2 cells. Zhou SS, et al. Exp Cell Res, 2012 Aug 1. PMID 22510436
  2. Increased expression of a homologue of drosophila tissue polarity gene "frizzled" in left ventricular hypertrophy in the rat, as identified by subtractive hybridization. Blankesteijn WM, et al. J Mol Cell Cardiol, 1996 May. PMID 8762054
  3. A homologue of Drosophila tissue polarity gene frizzled is expressed in migrating myofibroblasts in the infarcted rat heart. Blankesteijn WM, et al. Nat Med, 1997 May. PMID 9142123
  4. Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray technology. Catherino WH, et al. Fertil Steril, 2003 Aug. PMID 12909487
  5. Up-regulation of Frizzled-10 (FZD10) by beta-estradiol in MCF-7 cells and by retinoic acid in NT2 cells. Saitoh T, et al. Int J Oncol, 2002 Jan. PMID 11743650

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a novel pathogenesis of the contribution of downregulation of neurotrophins to the inhibition of the interaction between Wnt5a and Frizzled-2 in astrocytes in minimal hepatic encephalopathy
    Title: The Involvement of the Decrease of Astrocytic Wnt5a in the Cognitive Decline in Minimal Hepatic Encephalopathy.
  2. H9c2 cell treatment with resveratrol significantly reduces the expression of Frizzled2 and Wnt5a.
    Title: Resveratrol attenuates hypoxia/reoxygenation‑induced Ca2+ overload by inhibiting the Wnt5a/Frizzled‑2 pathway in rat H9c2 cells.
  3. These findings demonstrated that the Wnt5a/Fzd2 signaling pathway contributed to increasing intracellular Ca(2) in nerve cells under physiological and pathological conditions
    Title: Suppression of Frizzled-2-mediated Wnt/Ca²⁺ signaling significantly attenuates intracellular calcium accumulation in vitro and in a rat model of traumatic brain injury.
  4. upon binding to Wnt5a, increased Frizzled-2 expression after hypoxia/reoxygenation treatment activated intracellular calcium release in H9c2 cells
    Title: Suppression of rat Frizzled-2 attenuates hypoxia/reoxygenation-induced Ca2+ accumulation in rat H9c2 cells.
  5. role of phosphodiesterase and of cGMP in Frizzled-2 signaling
    Title: Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP.
  6. Highly upregulated expression of Wnt5a and its receptor frizzled 2 implicates this pathway in differentiation of quiescent hepatic stellate cells into myofibroblasts.
    Title: Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables Wnt receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Wnt receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in Wnt signaling pathway, calcium modulating pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell-cell signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to peptide hormone stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to vitamin D IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to vitamin D IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cochlea morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hard palate development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner ear receptor cell development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within membranous septum morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within muscular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sensory perception of smell ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
Preferred Names
frizzled-2
Names
Drosophila polarity gene (frizzled) homologue
Drosophila polarity gene homolog 2
frizzled family receptor 2
fz-2
rFz2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172035.2 → NP_742032.2  frizzled-2 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q08464
    UniProtKB/TrEMBL
    A6HJL6, G3V954
    Related
    ENSRNOP00000112818.1, ENSRNOT00000145471.1
    Conserved Domains (2) summary
    cd07464
    Location:40 → 166
    CRD_FZ2; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 2 (Fz2) receptor
    cd15245
    Location:239 → 568
    7tmF_FZD2; class F frizzled subfamily 2, member of 7-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    88061988..88063898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08464.1 GenPept UniProtKB/Swiss-Prot:Q08464

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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