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Fzd2 frizzled class receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64512, updated on 12-Jan-2022

Summary

Official Symbol
Fzd2provided by RGD
Official Full Name
frizzled class receptor 2provided by RGD
Primary source
RGD:71012
See related
Ensembl:ENSRNOG00000021962
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fz-10; Fzd10
Summary
Enables Wnt-activated receptor activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; Wnt signaling pathway; and cellular response to vitamin D. Located in plasma membrane. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in omodysplasia 2. Orthologous to human FZD2 (frizzled class receptor 2). [provided by Alliance of Genome Resources, Nov 2021]
Orthologs
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Genomic context

See Fzd2 in Genome Data Viewer
Location:
10q32.1
Exon count:
1
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87561866..87563776)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (90550147..90552057)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene uncharacterized LOC102550111 Neighboring gene hypothetical protein LOC688214 Neighboring gene meiosis specific with coiled-coil domain

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables Wnt-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Wnt-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables Wnt-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables Wnt-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Wnt signaling pathway, calcium modulating pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cell activation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to peptide hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to vitamin D IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cochlea morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cochlea morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in hard palate development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hard palate development ISO
Inferred from Sequence Orthology
more info
 
involved_in inner ear receptor cell development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inner ear receptor cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in membranous septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within membranous septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in muscular septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within muscular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in planar cell polarity pathway involved in neural tube closure IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within sensory perception of smell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
frizzled-2
Names
Drosophila polarity gene (frizzled) homologue
Drosophila polarity gene homolog 2
frizzled family receptor 2
fz-2
rFz2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172035.2NP_742032.2  frizzled-2 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000220
    Related
    ENSRNOP00000036154.2, ENSRNOT00000032944.3
    Conserved Domains (2) summary
    cd07464
    Location:40166
    CRD_FZ2; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 2 (Fz2) receptor
    cd15245
    Location:239568
    7tmF_FZD2; class F frizzled subfamily 2, member of 7-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    87561866..87563776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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