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SH3BGRL SH3 domain binding glutamate rich protein like [ Homo sapiens (human) ]

Gene ID: 6451, updated on 22-Sep-2022

Summary

Official Symbol
SH3BGRLprovided by HGNC
Official Full Name
SH3 domain binding glutamate rich protein likeprovided by HGNC
Primary source
HGNC:HGNC:10823
See related
Ensembl:ENSG00000131171 MIM:300190; AllianceGenome:HGNC:10823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SH3BGR; HEL-S-115
Summary
Predicted to enable SH3 domain binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 90.2), urinary bladder (RPKM 79.0) and 25 other tissues See more
Orthologs
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Genomic context

See SH3BGRL in Genome Data Viewer
Location:
Xq21.1
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (81202102..81298547)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (79635822..79732260)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (80457601..80554046)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 995, pseudogene Neighboring gene high mobility group nucleosome binding domain 5 Neighboring gene uncharacterized LOC124905203 Neighboring gene uncharacterized LOC105373284

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117402

General protein information

Preferred Names
SH3 domain-binding glutamic acid-rich-like protein
Names
SH3 domain binding glutamic acid-rich protein like
SH3-binding domain glutamic acid-rich protein like
epididymis secretory protein Li 115

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003022.3NP_003013.1  SH3 domain-binding glutamic acid-rich-like protein

    See identical proteins and their annotated locations for NP_003013.1

    Status: VALIDATED

    Source sequence(s)
    BC103762, CN272007
    Consensus CDS
    CCDS14449.1
    UniProtKB/Swiss-Prot
    O75368, Q9H0N8
    UniProtKB/TrEMBL
    V9HW48
    Related
    ENSP00000362308.5, ENST00000373212.6
    Conserved Domains (1) summary
    cd03030
    Location:297
    GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    81202102..81298547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531014.2XP_011529316.1  SH3 domain-binding glutamic acid-rich-like protein isoform X2

    See identical proteins and their annotated locations for XP_011529316.1

    Conserved Domains (1) summary
    cd03030
    Location:53134
    GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...
  2. XM_047442354.1XP_047298310.1  SH3 domain-binding glutamic acid-rich-like protein isoform X2

  3. XM_011531013.1XP_011529315.1  SH3 domain-binding glutamic acid-rich-like protein isoform X1

    Conserved Domains (1) summary
    cd03030
    Location:78159
    GRX_SH3BGR; Glutaredoxin (GRX) family, SH3BGR (SH3 domain binding glutamic acid-rich protein) subfamily; a recently-identified subfamily composed of SH3BGR and similar proteins possessing significant sequence similarity to GRX, but without a redox active CXXC motif. ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    79635822..79732260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)