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CPEB1 cytoplasmic polyadenylation element binding protein 1 [ Homo sapiens (human) ]

Gene ID: 64506, updated on 11-Aug-2018

Summary

Official Symbol
CPEB1provided by HGNC
Official Full Name
cytoplasmic polyadenylation element binding protein 1provided by HGNC
Primary source
HGNC:HGNC:21744
See related
Ensembl:ENSG00000214575 MIM:607342; Vega:OTTHUMG00000172877
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPEB; CPEB-1; h-CPEB; CPE-BP1; hCPEB-1
Summary
This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression
Biased expression in testis (RPKM 19.2), brain (RPKM 6.3) and 8 other tissues See more
Orthologs

Genomic context

See CPEB1 in Genome Data Viewer
Location:
15q25.2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (82543201..82648016, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (83211948..83316762, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene dynamin 1 pseudogene 38 Neighboring gene ribosomal protein S17 Neighboring gene CPEB1 antisense RNA 1 Neighboring gene adaptor related protein complex 3 subunit beta 2 Neighboring gene serine and arginine rich splicing factor 9 pseudogene Neighboring gene epididymal protein pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: RPS17

Homology

Clone Names

  • FLJ13203, MGC34136, MGC60106

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mRNA 3'-UTR AU-rich region binding ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation factor activity, RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation repressor activity, mRNA regulatory element binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation repressor activity, mRNA regulatory element binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mRNA polyadenylation IDA
Inferred from Direct Assay
more info
PubMed 
translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
P-body IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
messenger ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytoplasmic polyadenylation element-binding protein 1
Names
CPE-binding protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079533.1NP_001073001.1  cytoplasmic polyadenylation element-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001073001.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as short, contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus and lacks a central 5 aa segment, compared to isoform 1.
    Source sequence(s)
    AC010724, AF329403, AL832156, DA705313
    Consensus CDS
    CCDS42072.2
    UniProtKB/Swiss-Prot
    Q9BZB8
    Related
    ENSP00000483590.1, OTTHUMP00000276417, ENST00000618449.4, OTTHUMT00000421101
    Conserved Domains (4) summary
    cd12723
    Location:234341
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:352437
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:429484
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
  2. NM_001079534.1NP_001073002.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001073002.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3, 4, and 5 encode the same isoform.
    Source sequence(s)
    AC010724, AF329403, AK023265, AL832156, DA705313
    Consensus CDS
    CCDS45330.2
    UniProtKB/Swiss-Prot
    Q9BZB8
    Related
    ENSP00000483857.1, OTTHUMP00000276420, ENST00000611163.4, OTTHUMT00000421105
    Conserved Domains (4) summary
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347432
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
  3. NM_001079535.1NP_001073003.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001073003.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3, 4, and 5 encode the same isoform.
    Source sequence(s)
    AC010724, AF329403, AL832156, BC035348, DA340952, DA705313
    Consensus CDS
    CCDS45330.2
    UniProtKB/Swiss-Prot
    Q9BZB8
    Related
    ENSP00000477557.1, OTTHUMP00000276422, ENST00000617462.4, OTTHUMT00000421103
    Conserved Domains (4) summary
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347432
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
  4. NM_001288819.1NP_001275748.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001275748.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3, 4, and 5 encode the same isoform.
    Source sequence(s)
    AK300105, AL832156, BM715948, BX649159, HY191346
    Consensus CDS
    CCDS45330.2
    UniProtKB/Swiss-Prot
    Q9BZB8
    Related
    ENSP00000484549.1, OTTHUMP00000276423, ENST00000620182.4, OTTHUMT00000421098
    Conserved Domains (4) summary
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347432
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
  5. NM_001288820.1NP_001275749.1  cytoplasmic polyadenylation element-binding protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001275749.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK301728, AL832156, BM715948, BX649159, DA705313, HY191346
    UniProtKB/TrEMBL
    B4DWY2
    Conserved Domains (4) summary
    cd12723
    Location:83185
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:196281
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:273328
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:181
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
  6. NM_001365240.1NP_001352169.1  cytoplasmic polyadenylation element-binding protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC105339, AC110291, AC245033
  7. NM_001365241.1NP_001352170.1  cytoplasmic polyadenylation element-binding protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC105339, AC110291, AC245033
  8. NM_001365242.1NP_001352171.1  cytoplasmic polyadenylation element-binding protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC105339, AC110291, AC245033
  9. NM_001365243.1NP_001352172.1  cytoplasmic polyadenylation element-binding protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC105339, AC110291, AC245033
  10. NM_001365244.1NP_001352173.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC105339, AC110291, AC245033
  11. NM_001365245.1NP_001352174.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC105339, AC110291, AC245033
  12. NM_001365246.1NP_001352175.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC105339, AC110291, AC245033
  13. NM_001365247.1NP_001352176.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC105339, AC110291, AC245033
  14. NM_001365248.1NP_001352177.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC245033
  15. NM_001365249.1NP_001352178.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC245033
  16. NM_001365250.1NP_001352179.1  cytoplasmic polyadenylation element-binding protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC245033
  17. NM_030594.4NP_085097.3  cytoplasmic polyadenylation element-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_085097.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC105339, AL832156, BC050629, BM715948, BX649159, HY007452, HY191346
    Consensus CDS
    CCDS45329.2
    UniProtKB/Swiss-Prot
    Q9BZB8
    Related
    ENSP00000477715.1, OTTHUMP00000276419, ENST00000615198.4, OTTHUMT00000421104
    Conserved Domains (4) summary
    cd12723
    Location:309411
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:422507
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:499554
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1307
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    82543201..82648016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187606.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    332306..416475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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