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CPEB1 cytoplasmic polyadenylation element binding protein 1 [ Homo sapiens (human) ]

Gene ID: 64506, updated on 11-Jun-2021

Summary

Official Symbol
CPEB1provided by HGNC
Official Full Name
cytoplasmic polyadenylation element binding protein 1provided by HGNC
Primary source
HGNC:HGNC:21744
See related
Ensembl:ENSG00000214575 MIM:607342
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPEB; CPEB-1; h-CPEB; CPE-BP1; hCPEB-1
Summary
This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression
Biased expression in testis (RPKM 19.2), brain (RPKM 6.3) and 8 other tissues See more
Orthologs
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Genomic context

See CPEB1 in Genome Data Viewer
Location:
15q25.2
Exon count:
23
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (82543201..82648795, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (83211951..83317546, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene dynamin 1 pseudogene 38 Neighboring gene ribosomal protein S17 Neighboring gene CPEB1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 5793 Neighboring gene adaptor related protein complex 3 subunit beta 2 Neighboring gene serine and arginine rich splicing factor 9 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: RPS17

Homology

Clone Names

  • FLJ13203, MGC34136, MGC60106

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA 3'-UTR AU-rich region binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation factor activity, RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation repressor activity, mRNA regulatory element binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation repressor activity, mRNA regulatory element binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mRNA polyadenylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in P-body IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of messenger ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytoplasmic polyadenylation element-binding protein 1
Names
CPE-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079533.2NP_001073001.1  cytoplasmic polyadenylation element-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001073001.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as short, contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus and lacks a central 5 aa segment, compared to isoform 1. Variants 2 and 25 both encode the same isoform (2).
    Source sequence(s)
    AC010724, AF329403, AL832156
    Consensus CDS
    CCDS42072.2
    UniProtKB/Swiss-Prot
    Q9BZB8
    Related
    ENSP00000483590.1, ENST00000618449.4
    Conserved Domains (4) summary
    pfam16366
    Location:429484
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234341
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:352435
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  2. NM_001079534.2NP_001073002.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001073002.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3-5, 11-16, and 26-32 all encode the same isoform (3).
    Source sequence(s)
    AC010724, AF329403, AK023265, AL832156, DA705313
    Consensus CDS
    CCDS45330.2
    UniProtKB/Swiss-Prot
    Q9BZB8
    Related
    ENSP00000483857.1, ENST00000611163.4
    Conserved Domains (4) summary
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347430
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  3. NM_001079535.2NP_001073003.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001073003.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3-5, 11-16, and 26-32 all encode the same isoform (3).
    Source sequence(s)
    AC010724, AF329403, AL832156, BC035348, DA340952, DA705313
    Consensus CDS
    CCDS45330.2
    UniProtKB/Swiss-Prot
    Q9BZB8
    Related
    ENSP00000477557.1, ENST00000617462.4
    Conserved Domains (4) summary
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347430
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  4. NM_001288819.2NP_001275748.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001275748.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3-5, 11-16, and 26-32 all encode the same isoform (3).
    Source sequence(s)
    AC105339, AC110291, AC245033
    Consensus CDS
    CCDS45330.2
    UniProtKB/Swiss-Prot
    Q9BZB8
    Related
    ENSP00000484549.1, ENST00000620182.4
    Conserved Domains (4) summary
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347430
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  5. NM_001288820.2NP_001275749.1  cytoplasmic polyadenylation element-binding protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001275749.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 6, 34, and 35 all encode the same isoform (4).
    Source sequence(s)
    AK301728, AL832156, BM715948, BX649159, HY191346
    UniProtKB/TrEMBL
    B4DWY2
    Conserved Domains (4) summary
    pfam16366
    Location:273328
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:181
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:83185
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:196279
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  6. NM_001365240.1NP_001352169.1  cytoplasmic polyadenylation element-binding protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:526581
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:31334
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:336438
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:449532
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  7. NM_001365241.1NP_001352170.1  cytoplasmic polyadenylation element-binding protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC105339, AC110291, AC245033
    Related
    ENSP00000481010.1, ENST00000614918.4
    Conserved Domains (4) summary
    pfam16366
    Location:526581
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:31334
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:336438
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:449532
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  8. NM_001365242.1NP_001352171.1  cytoplasmic polyadenylation element-binding protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC105339, AC110291, AC245033
    Related
    ENSP00000507835.1, ENST00000684509.1
    Conserved Domains (4) summary
    pfam16366
    Location:526581
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:31334
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:336438
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:449532
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  9. NM_001365243.1NP_001352172.1  cytoplasmic polyadenylation element-binding protein 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC105339, AC110291, AC245033
    Related
    ENSP00000478598.1, ENST00000617958.4
    Conserved Domains (4) summary
    cd12723
    Location:309416
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:427512
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:504559
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1307
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
  10. NM_001365244.1NP_001352173.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347430
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  11. NM_001365245.1NP_001352174.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347430
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  12. NM_001365246.1NP_001352175.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347430
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  13. NM_001365247.1NP_001352176.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347430
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  14. NM_001365248.1NP_001352177.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347430
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  15. NM_001365249.1NP_001352178.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347430
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  16. NM_001365250.1NP_001352179.1  cytoplasmic polyadenylation element-binding protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:429484
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234341
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:352435
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  17. NM_001387061.1NP_001373990.1  cytoplasmic polyadenylation element-binding protein 1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) encodes the longest isoform (7).
    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:531586
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:31334
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:336443
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:454537
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  18. NM_001387062.1NP_001373991.1  cytoplasmic polyadenylation element-binding protein 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 7-9 and 20-24, encodes isoform 5.
    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:526581
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:31334
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:336438
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:449532
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  19. NM_001387063.1NP_001373992.1  cytoplasmic polyadenylation element-binding protein 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 7-9, 19, and 21-24, encodes isoform 5.
    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:526581
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:31334
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:336438
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:449532
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  20. NM_001387064.1NP_001373993.1  cytoplasmic polyadenylation element-binding protein 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 7-9, 19, 20, and 22-24, encodes isoform 5.
    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:526581
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:31334
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:336438
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:449532
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  21. NM_001387065.1NP_001373994.1  cytoplasmic polyadenylation element-binding protein 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 7-9, 19-21, 23, and 24, encodes isoform 5.
    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:526581
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:31334
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:336438
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:449532
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  22. NM_001387066.1NP_001373995.1  cytoplasmic polyadenylation element-binding protein 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 7-9, 19-22, and 24, encodes isoform 5.
    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:526581
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:31334
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:336438
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:449532
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  23. NM_001387067.1NP_001373996.1  cytoplasmic polyadenylation element-binding protein 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 7-9 and 19-23, encodes isoform 5.
    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:526581
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:31334
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:336438
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:449532
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  24. NM_001387068.1NP_001373997.1  cytoplasmic polyadenylation element-binding protein 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variant 2, encodes isoform (2).
    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:429484
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234341
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:352435
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  25. NM_001387069.1NP_001373998.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variants 3-5, 11-16, and 27-32, encodes isoform 3.
    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347430
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  26. NM_001387070.1NP_001373999.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27), as well as variants 3-5, 11-16, 26, and 28-32, encodes isoform 3.
    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347430
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  27. NM_001387071.1NP_001374000.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28), as well as variants 3-5, 11-16, 26, 27, and 29-32, encodes isoform 3.
    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347430
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  28. NM_001387072.1NP_001374001.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variants 3-5, 11-16, 26-28, and 30-32, encodes isoform 3.
    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347430
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  29. NM_001387073.1NP_001374002.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variants 3-5, 11-16, 26-29, 31 and 32, encodes isoform 3.
    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347430
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  30. NM_001387074.1NP_001374003.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31), as well as variants 3-5, 11-16, 26-30, and 32, encodes isoform 3.
    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347430
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  31. NM_001387075.1NP_001374004.1  cytoplasmic polyadenylation element-binding protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32), as well as variants 3-5, 11-16, and 26-31, encodes isoform 3.
    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:424479
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234336
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:347430
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  32. NM_001387076.1NP_001374005.1  cytoplasmic polyadenylation element-binding protein 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC105339, AC110291, AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:412467
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1232
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:234324
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:335418
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  33. NM_001387077.1NP_001374006.1  cytoplasmic polyadenylation element-binding protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (34), as well as variants 6 and 35, encodes isoform 4.
    Source sequence(s)
    AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:273328
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:181
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:83185
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:196279
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  34. NM_001387078.1NP_001374007.1  cytoplasmic polyadenylation element-binding protein 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (35), as well as variants 6 and 34, encodes isoform 4.
    Source sequence(s)
    AC245033
    Conserved Domains (4) summary
    pfam16366
    Location:273328
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:181
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus
    cd12723
    Location:83185
    RRM1_CPEB1; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:196279
    RRM2_CPEB1; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
  35. NM_030594.5NP_085097.3  cytoplasmic polyadenylation element-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_085097.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC105339, AL832156, BC050629, BM715948, BX649159, HY007452, HY191346
    Consensus CDS
    CCDS45329.2
    UniProtKB/Swiss-Prot
    Q9BZB8
    Related
    ENSP00000477715.1, ENST00000615198.4
    Conserved Domains (4) summary
    cd12723
    Location:309411
    RRM1_CPEB1; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    cd12725
    Location:422507
    RRM2_CPEB1; RNA recognition motif 2 in cytoplasmic polyadenylation element-binding protein 1 (CPEB-1) and similar proteins
    pfam16366
    Location:499554
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    pfam16368
    Location:1307
    CEBP1_N; Cytoplasmic polyadenylation element-binding protein 1 N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    82543201..82648795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187606.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    332306..430793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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