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SH3BGR SH3 domain binding glutamate rich protein [ Homo sapiens (human) ]

Gene ID: 6450, updated on 1-Jun-2020

Summary

Official Symbol
SH3BGRprovided by HGNC
Official Full Name
SH3 domain binding glutamate rich proteinprovided by HGNC
Primary source
HGNC:HGNC:10822
See related
Ensembl:ENSG00000185437 MIM:602230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
21-GARP
Expression
Biased expression in heart (RPKM 36.2), prostate (RPKM 11.6) and 10 other tissues See more
Orthologs

Genomic context

See SH3BGR in Genome Data Viewer
Location:
21q22.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (39445865..39515506)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (40817797..40887433)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene GET1-SH3BGR readthrough Neighboring gene ring finger protein 6 pseudogene 1 Neighboring gene guided entry of tail-anchored proteins factor 1 Neighboring gene lebercilin LCA5 like Neighboring gene microRNA 6508 Neighboring gene myosin light chain 6 pseudogene 2 Neighboring gene ribosomal protein S26 pseudogene 4 Neighboring gene JCAD pseudogene 1 Neighboring gene B3GALT5 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of SH3 domain binding glutamic acid-rich protein (SH3BGR) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough GET1-SH3BGR

Readthrough gene: GET1-SH3BGR, Included gene: GET1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol HDA PubMed 

General protein information

Preferred Names
SH3 domain-binding glutamic acid-rich protein
Names
SH3-binding domain and glutamic acid-rich protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001713.1NP_001001713.1  SH3 domain-binding glutamic acid-rich protein isoform b

    See identical proteins and their annotated locations for NP_001001713.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 5 encode the same isoform (b).
    Source sequence(s)
    AI338732, BC006371, BM474020, X93498
    Consensus CDS
    CCDS33560.1
    UniProtKB/Swiss-Prot
    P55822
    Related
    ENSP00000370011.3, ENST00000380637.7
    Conserved Domains (1) summary
    cl00388
    Location:150
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. NM_001317740.1NP_001304669.1  SH3 domain-binding glutamic acid-rich protein isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AF121897, AW962501, BM701533, BQ574343
    Conserved Domains (1) summary
    pfam04908
    Location:64161
    SH3BGR; SH3-binding, glutamic acid-rich protein
  3. NM_001317741.1NP_001304670.1  SH3 domain-binding glutamic acid-rich protein isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' most exon and lacks an exon in the central coding region compared to variant 1. These differences result in the use of alternate start codon compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    BG742101, BQ574343
    Consensus CDS
    CCDS82675.1
    UniProtKB/TrEMBL
    C9JJT2
    Related
    ENSP00000404980.1, ENST00000458295.5
    Conserved Domains (1) summary
    cl00388
    Location:150
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  4. NM_001317742.1NP_001304671.1  SH3 domain-binding glutamic acid-rich protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' most exon and lacks a portion of the 5' coding region compared to variant 1. These differences result in the use of alternate start codon compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus compared to isoform a. Variants 2 and 5 encode the same isoform (b).
    Source sequence(s)
    AF121781, AF121897, BI819819, BQ574343
    Consensus CDS
    CCDS33560.1
    UniProtKB/Swiss-Prot
    P55822
    Related
    ENSP00000370008.1, ENST00000380634.5
    Conserved Domains (1) summary
    cl00388
    Location:150
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  5. NM_007341.2NP_031367.1  SH3 domain-binding glutamic acid-rich protein isoform a

    See identical proteins and their annotated locations for NP_031367.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AI338732, BC006371, BM697281, X93498
    Consensus CDS
    CCDS13666.1
    UniProtKB/Swiss-Prot
    P55822
    Related
    ENSP00000332513.4, ENST00000333634.8
    Conserved Domains (1) summary
    pfam04908
    Location:64161
    SH3BGR; SH3-binding, glutamic acid-rich protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    39445865..39515506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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