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BLVRB biliverdin reductase B [ Homo sapiens (human) ]

Gene ID: 645, updated on 18-Sep-2024

Summary

Official Symbol
BLVRBprovided by HGNC
Official Full Name
biliverdin reductase Bprovided by HGNC
Primary source
HGNC:HGNC:1063
See related
Ensembl:ENSG00000090013 MIM:600941; AllianceGenome:HGNC:1063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLR; BVRB; SDR43U1; HEL-S-10
Summary
Enables biliverdin reductase (NAD(P)+) activity and riboflavin reductase (NADPH) activity. Involved in heme catabolic process. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bone marrow (RPKM 178.6), spleen (RPKM 63.9) and 23 other tissues See more
Orthologs
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Genomic context

See BLVRB in Genome Data Viewer
Location:
19q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (40447768..40465745, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (43268426..43286397, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40953675..40971652, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10627 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10629 Neighboring gene SERTAD3 antisense RNA 1 Neighboring gene SERTA domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10630 Neighboring gene spectrin beta, non-erythrocytic 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41029231-41029526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14656 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10635 Neighboring gene SH3KBP1 binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC117413

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables FMN reductase (NAD(P)H) activity IEA
Inferred from Electronic Annotation
more info
 
enables FMN reductase (NADH) activity IEA
Inferred from Electronic Annotation
more info
 
enables FMN reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 
enables biliverdin reductase [NAD(P)+] activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables biliverdin reductase [NAD(P)+] activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidyl-cysteine S-nitrosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables riboflavin reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables riboflavin reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables riboflavin reductase (NADPH) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
flavin reductase (NADPH)
Names
BVR-B
FR
GHBP
NADPH-dependent diaphorase
NADPH-flavin reductase
S-nitroso-CoA-assisted nitrosyltransferase
SNO-CoA-assisted nitrosyltransferase
biliverdin-IX beta-reductase
epididymis secretory protein Li 10
green heme-binding protein
short chain dehydrogenase/reductase family 43U, member 1
NP_000704.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000713.3NP_000704.1  flavin reductase (NADPH)

    See identical proteins and their annotated locations for NP_000704.1

    Status: VALIDATED

    Source sequence(s)
    AC010271, BC109371, BG340491, BU528444
    Consensus CDS
    CCDS33029.1
    UniProtKB/Swiss-Prot
    A6NKD8, B2R5C6, P30043, P32078, P53005, Q32LZ2
    UniProtKB/TrEMBL
    V9HWI1
    Related
    ENSP00000263368.3, ENST00000263368.9
    Conserved Domains (1) summary
    cd05244
    Location:5200
    BVR-B_like_SDR_a; biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    40447768..40465745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    43268426..43286397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)