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BLVRB biliverdin reductase B [ Homo sapiens (human) ]

Gene ID: 645, updated on 5-Jul-2025
Official Symbol
BLVRBprovided by HGNC
Official Full Name
biliverdin reductase Bprovided by HGNC
Primary source
HGNC:HGNC:1063
See related
Ensembl:ENSG00000090013 MIM:600941; AllianceGenome:HGNC:1063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLR; BVRB; SDR43U1; HEL-S-10
Summary
Enables biliverdin reductase [NAD(P)H] activity; peptidyl-cysteine S-nitrosylase activity; and riboflavin reductase (NADPH) activity. Involved in heme catabolic process; megakaryocyte differentiation; and negative regulation of insulin receptor signaling pathway. Located in cytosol; nucleoplasm; and plasma membrane. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in bone marrow (RPKM 178.6), spleen (RPKM 63.9) and 23 other tissues See more
Orthologs
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See BLVRB in Genome Data Viewer
Location:
19q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (40447768..40465745, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (43268426..43286397, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40953675..40971652, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10627 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10629 Neighboring gene SERTAD3 antisense RNA 1 Neighboring gene SERTA domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10630 Neighboring gene spectrin beta, non-erythrocytic 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41029231-41029526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14656 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10635 Neighboring gene SH3KBP1 binding protein 1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC117413

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables FMN reductase (NADH) activity IEA
Inferred from Electronic Annotation
more info
 
enables FMN reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 
enables biliverdin reductase [NAD(P)H] activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables biliverdin reductase [NAD(P)H] activity IDA
Inferred from Direct Assay
more info
PubMed 
enables biliverdin reductase [NAD(P)H] activity IEA
Inferred from Electronic Annotation
more info
 
enables biliverdin reductase [NAD(P)H] activity TAS
Traceable Author Statement
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidyl-cysteine S-nitrosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidyl-cysteine S-nitrosylase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables riboflavin reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables riboflavin reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables riboflavin reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 
enables riboflavin reductase (NADPH) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
flavin reductase (NADPH)
Names
BVR-B
FR
GHBP
NADPH-dependent diaphorase
NADPH-flavin reductase
S-nitroso-CoA-assisted nitrosyltransferase
SNO-CoA-assisted nitrosyltransferase
biliverdin-IX beta-reductase
epididymis secretory protein Li 10
green heme-binding protein
short chain dehydrogenase/reductase family 43U, member 1
NP_000704.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000713.3NP_000704.1  flavin reductase (NADPH)

    See identical proteins and their annotated locations for NP_000704.1

    Status: VALIDATED

    Source sequence(s)
    AC010271, BC109371, BG340491, BU528444
    Consensus CDS
    CCDS33029.1
    UniProtKB/Swiss-Prot
    A6NKD8, B2R5C6, P30043, P32078, P53005, Q32LZ2
    UniProtKB/TrEMBL
    V9HWI1
    Related
    ENSP00000263368.3, ENST00000263368.9
    Conserved Domains (1) summary
    cd05244
    Location:5200
    BVR-B_like_SDR_a; biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    40447768..40465745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    43268426..43286397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)