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BLVRB biliverdin reductase B [ Homo sapiens (human) ]

Gene ID: 645, updated on 12-Oct-2019

Summary

Official Symbol
BLVRBprovided by HGNC
Official Full Name
biliverdin reductase Bprovided by HGNC
Primary source
HGNC:HGNC:1063
See related
Ensembl:ENSG00000090013 MIM:600941
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLR; BVRB; SDR43U1; HEL-S-10
Summary
The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009]
Expression
Broad expression in bone marrow (RPKM 178.6), spleen (RPKM 63.9) and 23 other tissues See more
Orthologs

Genomic context

See BLVRB in Genome Data Viewer
Location:
19q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (40447768..40465745, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40953691..40971725, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SERTA domain containing 1 Neighboring gene uncharacterized LOC105372489 Neighboring gene SERTA domain containing 3 Neighboring gene spectrin beta, non-erythrocytic 4 Neighboring gene SH3KBP1 binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117413

Gene Ontology Provided by GOA

Function Evidence Code Pubs
biliverdin reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
riboflavin reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
heme catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
heme catabolic process TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
terminal bouton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
flavin reductase (NADPH)
Names
BVR-B
FR
GHBP
NADPH-dependent diaphorase
NADPH-flavin reductase
biliverdin-IX beta-reductase
epididymis secretory protein Li 10
green heme-binding protein
short chain dehydrogenase/reductase family 43U, member 1
NP_000704.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000713.3NP_000704.1  flavin reductase (NADPH)

    See identical proteins and their annotated locations for NP_000704.1

    Status: VALIDATED

    Source sequence(s)
    AC010271, BC109371, BG340491, BU528444
    Consensus CDS
    CCDS33029.1
    UniProtKB/Swiss-Prot
    P30043
    UniProtKB/TrEMBL
    V9HWI1
    Related
    ENSP00000263368.3, ENST00000263368.9
    Conserved Domains (1) summary
    cd05244
    Location:5200
    BVR-B_like_SDR_a; biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    40447768..40465745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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